Nature - Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine...

Nature Communications - Females are more sensitive to social exclusion and loneliness, risk factors for anxiety and stressrelated disorders. Here, the authors identified molecular signals in the...

Background: Posttraumatic stress disorder (PTSD) is associated with maladaptive memory reconsolidation and overgeneralized fear responses. EMDR therapy promotes trauma reprocessing by activating th...

Impaired GABAergic inhibition, so-called neural disinhibition, in the prefrontal cortex and hippocampus has been linked to cognitive deficits. The novel object recognition (NOR) task has been used...

Molecular Psychiatry - Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation

Huang et al. redefined the vLGN/IGL—a region traditionally associated with vision—as a multimodal hub critical for stress resilience in mice. Locus coeruleus inputs to this region translate salient...

Neuropsychopharmacology - Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model

Post-traumatic stress disorder is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the...

Translational Psychiatry - Social support facilitates threat extinction retention in humans: an fMRI study

Communications Psychology - This study examined whether behavioral memory updating can reduce fear in adolescents with and without chronic pain. While self-reported fear did not differ, neural data...

Translational Psychiatry - Psychedelics and ketamine/esketamine in depressive disorders: biological mechanisms and associated neuroimaging and clinical changes

In CA1 hippocampus, pyramidal cells (PCs) can be classified as deep or superficial based on their radial position within the stratum pyramidale. Deep and superficial PCs form biased circuits with...

Neuropsychopharmacology - Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects