Frontiers - Pharmacology and Toxicology
@FrontPharmacol
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Research and updates from all @FrontiersIn journals in the field of pharmacology and toxicology. #openaccess
Lausanne, Switzerland
Joined October 2011
Your research is the real superpower. With Chief Editor Heike Wulff and a thriving research community publishing in Frontiers in Pharmacology, we’ve reached 532k citations. Together, we are making an impact ⬇.
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New Research: From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health #FrontiersIn #Pharmacology.
frontiersin.org
Tetramethylpyrazine (TMP), a bioactive alkaloid isolated from the traditional Chinese medicine Ligusticum wallichii (Chuanxiong), has gained significant atte...
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New Research: Inverse association between pre-high-altitude potassium levels and coronary microvascular disease at high altitude: a case-control study #FrontiersIn #Pharmacology.
frontiersin.org
Background and ObjectivesHigh-altitude hypoxia is known to impair cardiac microvascular function, a pathophysiological state recognized as coronary microvasc...
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New Research: Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy #FrontiersIn #Pharmacology.
frontiersin.org
BackgroundCannabidiol (CBD) reduces the frequency of seizures in individuals with specific epileptic syndromes, but its effectiveness for other types of drug...
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New Research: Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets #FrontiersIn #Pharmacology.
frontiersin.org
IntroductionAge-related macular degeneration (AMD) is a leading cause of vision loss in older adults, with limited effective treatments available. This study...
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New Research: Model-based prediction of nanoparticle and dissolved form ratios using total concentration data: a case study of SNB-101 #FrontiersIn #Pharmacology.
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New Research: 2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity #FrontiersIn #Pharmacology.
frontiersin.org
IntroductionThe development of new drugs for Alzheimer’s disease (AD) remains a major challenge due to the disorder’s complex and multifactorial nature. 2′-F...
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New Research: Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study #FrontiersIn #Toxicology.
frontiersin.org
The CLARITY-BPA Core Study is the most comprehensive animal study of oral bisphenol A (BPA) exposure to date. Rats were exposed daily, in utero until postnat...
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New Research: Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds #FrontiersIn #Toxicology.
frontiersin.org
IntroductionEfficient preclinical prediction of cardiovascular side effects poses a pivotal challenge for the pharmaceutical industry. Human induced pluripot...
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New Research: Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock #FrontiersIn #Pharmacology.
frontiersin.org
Background/objectivesBurns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the ...
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New Research: Modulatory role of Spirulina platensis in oxidative stress, apoptosis, and gene expression in a rat model of dexamethasone-induced hepatotoxicity #FrontiersIn #Pharmacology.
frontiersin.org
The rising prevalence of hyperlipidemia and hepatic disorders has intensified interest in the therapeutic use of functional foods and botanical drugs. Spirul...
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New Research: Editorial: Advances in pharmacotherapy for alcohol use disorder: from mechanisms to clinical interventions #FrontiersIn #Pharmacology.
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New Research: Case Report: Hydronephrosis and nephrogenic adenoma secondary to Stevens-Johnson syndrome #FrontiersIn #Pharmacology.
frontiersin.org
IntroductionStevens–Johnson syndrome is a rare, severe cutaneous adverse reaction. There is a lack of literature reporting the complications of the bladder a...
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New Research: Fucoidan from Fucus vesiculosus alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration #FrontiersIn #Pharmacology.
frontiersin.org
Metabolic and alcohol-related liver disease (MetALD), characterized by excessive alcohol intake in individuals with metabolic dysfunction, is a growing healt...
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New Research: Real-world study on adverse drug reactions of pembrolizumab in endometrial cancer treatment: insights from the FAERS database #FrontiersIn #Pharmacology.
frontiersin.org
ObjectivePembrolizumab is a key drug in the immunotherapy of endometrial cancer (EC) and has improved the prognosis to some extent. However, adverse drug eve...
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New Research: Validation of a novel questionnaire for assessing occupational exposure to organophosphate pesticides in Chilean agricultural workers #FrontiersIn #Toxicology.
frontiersin.org
BackgroundUnintentional pesticide poisoning is a global health concern, disproportionately affecting agricultural workers in developing countries due to inad...
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New Research: Global research trends on ALK-TKIs in non-small cell lung cancer: a bibliometric analysis #FrontiersIn #Pharmacology.
frontiersin.org
BackgroundLung cancer remains the leading cause of cancer-related incidence and mortality worldwide. Non-small cell lung cancer (NSCLC) constitutes the most ...
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New Research: Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis #FrontiersIn #Pharmacology.
frontiersin.org
ObjectiveThe potential of ciprofol in endoscopic anesthesia is receiving increasing attention. Compared to propofol, ciprofol exhibits stronger sedative effe...
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New Research: Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review #FrontiersIn #Pharmacology.
frontiersin.org
Pramipexole, a novel dopamine receptor agonist, is widely used in the treatment of Parkinson’s disease and related syndromes. While studies have demonstrated...
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New Research: Case Report: Micronized purified flavonoid fraction [Daflon]-induced bradycardia #FrontiersIn #Pharmacology.
frontiersin.org
IntroductionFlavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders. Micronized purified flavonoid fra...
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New Research: Beyond efficacy parity: a novel cost-equilibrium framework for value assessment of competing third-line therapies in metastatic colorectal cancer #FrontiersIn #Pharmacology.
frontiersin.org
BackgroundColorectal cancer remains a leading cause of global cancer mortality, with metastatic CRC (mCRC) requiring sequential therapies after first line tr...
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