Tadasu Nozaki
@tadasu443
Followers
579
Following
5K
Media
59
Statuses
2K
Chromosome postdoc researcher @UMassAmherst. Tweets in English and Japanese (時々英語、時々日本語) #LiveCell #SingleMolecule #Meiosis #Chromatin #pairing
Massachusetts, USA
Joined January 2010
Our paper was published in @Nature. We discovered a new aspect of the meiotic homolog pairing process named Rapid Homolog Juxtaposition (RHJ). During RHJ, homologous loci undergo spatial juxtaposition from far apart to very close together in a short time. https://t.co/AvWJb113Ob
nature.com
Nature - Homologue juxtaposition during meiosis is examined in real time by imaging of tagged chromosomal loci at high resolution in budding yeast, showing that corresponding loci come together and...
11
53
155
We’re recruiting PhD students. If you’re interested in chromosome biology or imaging, please apply to the MCB or Plant Biology graduate programs at UMass (deadline is soon, 12/1). DM me for projects or questions. https://t.co/aDYV7p9gYQ
https://t.co/XLeGmdpNib
0
3
9
I launched my lab at @UMassAmherst this fall. We study the mechanisms of meiotic homolog pairing using advanced live‑cell and super‑resolution imaging. Currently in budding yeast, with plans to expand to other eukaryotes. #Chromosome #Meiosis #Mitosis
https://t.co/BPvQghmCx2
1
6
23
(1/8) Excited to see our collab w. @ViraatGoel Ed Banigan @ngaboreden James Jusuf, Leonid Mirny and Gerd Blobel out in @NatureSMB
https://t.co/2Ri3nom8jt This was co-submitted with A Schooley and Job Dekker's preprint https://t.co/0Y6CmePM1Z which should also be online soon.
(1/n) From @ViraatGoel @Irate_Physicist et al. collab w @blobelgroup @leonidmirny
https://t.co/CdI7n2P31a RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator
4
15
47
Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬 @shiori_iida @MasaAShimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗 https://t.co/2iISQjxjgh (1/3)
2
51
189
Glad to share our latest publication in Nature Genetics @NatureGenet: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique.
8
44
228
Spindle checkpoint can secure additional cheating time for selfish expanded centromeres https://t.co/ZCa9ePnBLQ
@CurrentBiology @TakashiAkeraLab
cell.com
Expanded centromere DNA repeats violate Mendel’s law of segregation by preferentially segregating to the egg in animals and plants. Using oocytes collected from hybrid mice, Walton et al. show that...
1
6
21
Two-color 3D structured illumination modes on MOSAIC: widefield SIM @ 32 sec intervals; two lattice light sheet SIM movies at 6 sec and 10 sec intervals; and image scanning microscopy at 17.5 sec intervals.
0
16
85
DNA mutagenesis driven by transcription factor competition with mismatch repair: Cell
cell.com
Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.
0
15
95
Enjoy Dr. Parth Desai's recent study of the suppression of DNA strand separation by molecular crowding https://t.co/n32nYQyrUd
#biophysics #singlemolecule #DNA
0
2
13
Our new work @biorxivpreprint 🔗 https://t.co/rpWHc1Br9k BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. @semeigazin @katsu_s_minami @MasaAShimazoe
4
44
183
We have a fun update on DynaCLR ( https://t.co/xcCmu0bURH), a self-supervised method for learning cell state dynamics from 3D multi-channel movies! Congratulations, team @czbiohub, for reaching this milestone! Special thanks to Carolina Arias and her team for the close
arxiv.org
We report DynaCLR, a self-supervised method for embedding cell and organelle Dynamics via Contrastive Learning of Representations of time-lapse images. DynaCLR integrates single-cell tracking and...
Excited to share an update on #DynaCLR—a self-supervised method to learn dynamic cell & organelle embeddings from time-lapse microscopy using contrastive learning. DynaCLR combines single-cell tracking & time-aware sampling for robust representations. https://t.co/7llrYuZBfz
0
6
22
In the latest issue! Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors
cell.com
This study demonstrates that extrachromosomal DNA (ecDNA) replication induces DNA double-strand breaks and activates the DNA damage response (DDR). The DDR pathways, such as alt-NHEJ, are critical...
0
18
92
high-throughput single-molecule platform to study DNA supercoiling effect on protein–DNA interactions https://t.co/vD3sDJ9mZY
2
26
124
In the latest issue! High-resolution dynamic imaging of chromatin DNA communication using Oligo-LiveFISH
0
11
77
Now online! Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes
2
26
141
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
49
415
2K
Happy to (FINALLY!!) share our new paper in @ScienceMagazine !!! "In-insect synthesis of oxygen-doped molecular nanocarbons"🐛 Read the full paper: https://t.co/w4zolVi8xe Huge thanks to our amazing co-authors, lab members, and everyone involved!!!!🙌
science.org
Many functional molecules and materials have been produced with organic chemistry or with in vitro enzymatic approaches. Individual organisms, such as insects, have the potential to serve as natural...
0
35
159
#TansleyReview Exploring the untapped potential of single-cell and spatial omics in plant biology Tatsuya Nobori @nobolly 📖 https://t.co/ouitYxVLoL
1
34
140
The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:
18
297
2K
New findings in Science demonstrate that successful mitosis may draw on more mechanisms than commonly assumed. Learn more in a new #SciencePerspective: https://t.co/j6nLJSvjMV
14
109
369