John F Marko
@JohnFMarko
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Professor, Molecular Biosciences and Physics & Astronomy, Northwestern University πππΈπ¦π¬π
Evanston, Illinois, USA
Joined April 2013
Enjoy Dr. Parth Desai's recent study of the suppression of DNA strand separation by molecular crowding https://t.co/n32nYQyrUd
#biophysics #singlemolecule #DNA
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Commemorate the life and science of our dear departed colleague Jon Widom - this Thurs May 15 1230 pm in Pancoe Auditorium @NUmolbiosci @NorthwesternU - our distinguished Widom Lecturer is Prof. Lucy Bai @penn_state - Chromatin Accessibility and the 3D Genome
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Why did the US government decide to start funding science and training young scientists? Worth reading this answer written in 1945 - for the moment still posted on the @NSF website at
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Subchromosomal mechanics of pericentric and centromeric chromatin along stretched mitotic chromosomes - surprise is little effect of CENP-N and -C degradation on CENP-A organization https://t.co/WA8vmOgcQl From Ron Biggs and @StraightLab
#centromere #kinetochore #chromosome
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In case anyone is left out there, I'm pleased to report that Dr. Ning Liu's paper on mechanics of meitotic metaphase chromosomes, dependence on #cohesin #aging and #toxins was just published in eLife https://t.co/8CRaFUVZZX Enjoy!
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Just returned from the Topoisomeases in Biology and Medicine meeting https://t.co/3wloYxKKPp Thanks so much to organizers Yuk-Ching Tse-Dinh, Dagmar Klostermeier, Valerie Lamour @valeroche and John Nitiss for running a great meeting!
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To avoid piles of corporate nonsense in every new tab in Edge I embarked on a quest to have new tabs load a user-defined URL. Apparently possible only by adding a 3rd-party browser extension, e.g., https://t.co/Vhft18YJl3 It works but I'm sure the victory is only temporary.
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Widom Lecture today 1230 CDT - Livestream at https://t.co/YGWAFKMjJ2 Not sure if non- @NorthwesternU viewers will be able to watch (working on that). @NUmolbiosci @OhioState @lab_poirier @Poirier_Lab
https://t.co/uK3YlWZOYY
https://t.co/VgtwtzL2dK Lunch in Pancoe afterwards!
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Commemorate the life and science of our dear departed colleague Jon Widom on May 16 at 1230 pm in Pancoe Auditorium @NUmolbiosci @NorthwesternU - this year's distinguished lecturer is Prof. Michael Poirier @OhioState @lab_poirier @Poirier_Lab
https://t.co/uK3YlWZOYY
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Dr. Ron Biggs has set up a really great #YouTube library of #chromosome manipulation movies plus some lab classics - including detailed video protocols. Let us know if you find them useful!
youtube.com
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Cop on a Rooftop is in full effect at Dunkin located 1900 Dempster. Weβre here until noon. Stop by and help support the Special Olympics and our local athletes! #CopOnARooftop
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Amidst a lot of noise about our fair nation becoming a "geriatric oligarchy" I blundered across this 2014 academic paper https://t.co/w5z18FyhII Things have improved since 2014, right?
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Published! Stefanos Nomidis' MD simulations of SMC complexes translocating and loop-extruding according to the model of Diebold-Durand et al. (Mol. Cell. 2017)
academic.oup.com
Abstract. Structural Maintenance of Chromosomes (SMC) complexes play essential roles in genome organization across all domains of life. To determine how th
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I am recruiting a postdoctoral researcher (grant-funded position available now) interested in DNA-protein interactions and genome organization, using single-molecule techniques including magnetic tweezers and fluorescence approaches.
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Revised preprint - Stefanos Nimodis' MD simulations of the loop-capture model of SMC complexes https://t.co/7Zl0nzP9g2 DNA in the tripartite ring and broken symmetry of the complex itself permit processive translocation via large (up to 200 nm) steps
biorxiv.org
Structural Maintenance of Chromosomes (SMC) complexes play essential roles in genome organization across all domains of life. To determine how the activities of these large ( 50 nm) complexes are...
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Now in @eLife - how the much-loved nuclear protein HP1Ξ± controls nuclear shape and mechanics, stiffens mitotic chromosomes, and boosts mitotic reliability, via dimerization+chromatin cross-bridging: https://t.co/FoXmxuhOmo - a project facilitated by @4DNucleome and @NCIPhySci
elifesciences.org
Micromanipulation experiments demonstrate that HP1Ξ± strengthens interphase and mitotic chromosome mechanics and maintains nuclear shape by chromatin crosslinking, separate from histone methylation.
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"DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations" https://t.co/dYYOTEgvYg with S. Nomidis, @Gruber_Lausanne and @JohnFMarko
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ATP-dependent and supercoil-sensing DNA compaction by SMC5/6 - thanks to the D'Amours lab for involving us in this exciting project!
pubmed.ncbi.nlm.nih.gov
The structural organization of chromosomes is a crucial feature that defines the functional state of genes and genomes. The extent of structural changes experienced by genomes of eukaryotic cells can...
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https://t.co/grPqDv9YrF DNA plectoneme pinning by base pair mismatches - thanks Keir et al. for a great collaboration!
academic.oup.com
Abstract. Damaged or mismatched DNA bases result in the formation of physical defects in double-stranded DNA. In vivo, defects in DNA must be rapidly and e
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