Lorenz
@studerl
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Stem cell biologist @MSKCancerCenter studying human PSCs for modeling development & disease and for cell therapy. Opinions are my own and do not represent MSK.
New York, NY
Joined March 2009
Dr. @TabarViviane and Dr. @studerl, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve
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Things I wish more people knew about doing science in the US (thread):
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Congrats to @ZeltnerLab on their new paper. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine https://t.co/vhjSE8Qthf. It was exciting to see this story develop from way back.
science.org
Genipin rescues developmental and degenerative phenotypes of the peripheral neuropathy familial dysautonomia and enhances neuron regeneration.
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👏 Congratulations to Dr. Deb Schrag, Chair of the @MSK_DeptOfMed, and Dr. @studerl, Director of the Center for Stem Cell Biology at MSK, who were elected to the @theNAMedicine, one of the highest honors bestowed upon scientists worldwide. Learn more: https://t.co/N2NdRJv4TE
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📢 Join us! Developmental and stem cell biologists, checkout our tenure-track faculty position at Sloan Kettering. Apply by October 18. #DevBio #StemCell #hiringnow
https://t.co/9h9gl6EZEe
mskcc.org
The Sloan Kettering Institute is seeking innovative scientists to join our faculty.
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Excited to share the latest work from my lab and @em6wong led by @DanielMedinaC12 @tarek10281 @verpetrova. We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells. @MSKCancerCenter @MSK_CSCB @MSKEducation
https://t.co/JSOnogfLuC
biorxiv.org
Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular...
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This was a great episode indeed. Congrats to @bigosi and @TabarViviane
🥇 The top spot goes to Drs. Stefan Irion (@bigosi) and Viviane Tabar (@TabarViviane)! This episode was recorded live at @BlueRockTx and focuses on bemdaneprocel — a stem cell-derived investigational cell therapy for Parkinson’s disease! #InternationalPodcastDay
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Congratulations to Dr. Shuibing Chen (@ChenShuibing) on her lab's new @CellStemCell paper! Her team developed vascularized macrophage-islet #organoids to study damage from infection. Read the article: https://t.co/3n4X8STm5p Learn more about her work 👇
stemcellpodcast.com
Dr. Shuibing Chen is the Kilts Family Professor of Surgery at Weill Cornell Medicine. Her lab uses hiPSCs and ESCs for disease modeling and drug screening, with a focus on diabetes and infectious...
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Exciting opportunity for open tenure track positions in Developmental Biology & Stem Cell Biology @MSKCancerCenter (see Ad - https://t.co/BxutHyvFn1). Deadline for applications is October 14, 2024 ( https://t.co/8SJujIBPP0)
nature.com
Sloan Kettering Institute (MSK) invites applications for junior tenure-track faculty positions in the Development Biology Program...
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Great postdoc opportunity if you are interested in developing next gen human PSC based cell therapies for brain repair here at MSK
We have a postdoc opportunity to work on cell therapy for #Parkinson’s disease in a highly collaborative environment @MSKCancerCenter @MSKEducation Apply at
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Excited to see the work published @Nature. Excellent summary in thread below. Big collaborative effort with @ShenYingZhang1, @casanova_lab + many more. Special thanks to @yihaoo, @ZhiyongLiu7, Paul Bastard and in my lab @NoopurKhobrekar, Param Amin, @gabriele_ciceri & @harschnitz
1) Just out @Nature today! We show that human TMEFF1 is a restriction factor for #Herpes simplex virus 1(HSV1) in the brain, by limiting NECTIN1—HSV1-gD mediated HSV1 entry into cortical neurons. TMEFF1 defect can underlie HSV1 #encephalitis. https://t.co/ESeorkXBGC
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Excellent thread from @ShenYingZhang1 on this new collaborative story, and for our lab one of the first studies to test run new hindbrain neuron protocol developed by @harschnitz
(1) We are happy to share our new study, “SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency” @JExpMed! https://t.co/WIRWBLH9RJ. Accumulation of RNA lariats results in impaired antiviral immunity in hPSC-derived hindbrain neurons, underlying encephalitis.
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Look, it’s the @studerl lab past and present at #ISSCR2024. Getting together is another awesome part of attending this conference 🤩
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Super excited to see this study finally published after many years of work. Congrats to @NatSaurat for the heroic effort and to all the many amazing collaborators who made this work possible. Also big thanks to our funders particularly the JPB foundation, NIA and @ASAP_Research.
How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell
https://t.co/vycsfPED6g
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How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell
https://t.co/vycsfPED6g
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Excellent thread from @_SoyeonKoo on the paper (and also her thesis work 😊). Congrats!
Excited to share that my doctoral thesis work is out in @CellCellPress We investigated a molecular driver to trigger hPSC-derived midbrain dopamine neurons during engraftment in mice.
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@CellCellPress @TaeWanKim0 @studerl Transient TNF-α inhibition overcomes a p53-dependent survival restriction in grafted dopamine neurons as a clinically relevant strategy to promote functional dopamine neuronal engraftment in Parkinson’s disease
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Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. https://t.co/hYkW2fJ1qo
biorxiv.org
The directed differentiation of pluripotent stem cells (PSCs) from panels of genetically diverse individuals is emerging as a powerful experimental system for characterizing the impact of natural...
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Why do most dopamine neurons die shortly after transplantation and how can we fix it? Excited to see our story out at Cell. Congrats to @TaeWanKim0 & SoYeon Koo @MSKCancerCenter and to all the other collaborators who made this work possible.
cell.com
Transient TNF-α inhibition overcomes a p53-dependent program that restricts the survival of grafted dopamine neurons and offers a clinically relevant strategy to enhance survival and promote functi...
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Excellent to hear that the FDA gave RMAT designation to DA-01 (Bemdaneprocel) following the promising 18-month data in 12 patients from the BlueRock-sponsored dopamine neuron cell therapy trial in advanced PD – see also article below and BR press release
bluerocktx.com
Bemdaneprocel is the most clinically advanced investigational cell therapy in the U.S. for treating patients living with Parkinson’s disease
The FDA granted regenerative medicine advanced therapy (RMAT) designation to bemdaneprocel, a therapy being developed for Parkinson's. https://t.co/hMQCl280T2
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