Taewan Kim
@TaeWanKim0
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Assistant Professor at DGIST @ Stem cell / Epigenetic biologist, Studing Human Development and Disease using Pluripotent Stem Cell
Korea
Joined April 2020
Very excited to share our study is finally out in @CellCellPress. TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons: Cell
cell.com
Transient TNF-α inhibition overcomes a p53-dependent program that restricts the survival of grafted dopamine neurons and offers a clinically relevant strategy to enhance survival and promote functi...
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Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines: Cell Stem Cell
cell.com
Vaccarino and colleagues show that simultaneous orthogonal gradients of posteriorizing and ventralizing morphogens trigger gene regulatory programs in human stem cells, recreating forebrain, midbra...
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18 month data from the phase 1b single-arm, open-label clinical trial of AAV-GDNF in #Parkinsons by @ask_bio has been published; N=11; Well tolerated & associated with numerical stability (mild cohort; <5 yrs since dx) & improvement (moderate cohort) https://t.co/5sO1XOTqNz
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New data reveals region- & disease-specific changes in the levels of lipid species; Alterations in the levels of specific phosphatidylserine species in brain areas most affected in #Parkinsons; a-synuclein at mitochondria–ER membranes alters lipid metab. https://t.co/j5UtqHntKS
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Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines: Cell Stem Cell
cell.com
Vaccarino and colleagues show that simultaneous orthogonal gradients of posteriorizing and ventralizing morphogens trigger gene regulatory programs in human stem cells, recreating forebrain, midbra...
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Thrilled to share our review just published in @NeuroCellPress! Big shoutout to Ava, Mengmeng , and our entire team! https://t.co/DUBauRbexY
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Early results from an MSK study shows a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients is safe and may improve Parkinson’s symptoms. Read more via @NPR:
npr.org
Two new studies suggest that Parkinson's disease can potentially be treated with stem cells placed in a patient's brain.
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Dr. @TabarViviane and Dr. @studerl, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve
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As stem cell-based modeling of the human nervous system and disease advances, we recently shared a group-effort framework in @Nature on designing experiments with #organoids, #assembloids, and transplantation Here a few key takeaways in 6 slides👇
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Great opportunity. If you are interested, please apply! (Updated) DGIST 2025년 글로벌 포닥 지원사업 신규 공고(DGIST Global Postdoctoral Fellowship 2025 Announcement) | 채용정보 > BioJob | BRIC
ibric.org
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New research from @ZivGanOr & colleagues finds that plasma glucosylceramide levels are regulated by ATP10D & are not involved in #Parkinsons pathogenesis; Results "suggest that altering GlcCer levels is not a good therapeutic method for GBA1-PD" https://t.co/T2BtE8GE4n
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Interesting: New research reports that isoforms of mitochondrial regulator PGC-1α are driven from distinct brain cell-type specific promotors, repressed with aging, & integral in coordinating metabolism & growth signaling https://t.co/S8k3fsKxgR
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Nothing to see here MAGA, just science casually treating hearing loss
investor.regeneron.com
As presented at ARO, 10 of 11 children with at least one post-treatment assessment showed notable improvements in hearing Speech and development progress followed dramatic improvements in hearing in...
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Online Now! Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation https://t.co/wUgF3sMNnW
#stemcells
cell.com
(Cell Stem Cell 30, 1452–1471.e1–e10; November 2, 2023)
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Excited to share our “Robust and inducible genome editing via an all-in-one prime editor in human pluripotent stem cells," is now published @NatureComms
https://t.co/usYjX1iIo3
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Stem cell therapies that work: 10 Breakthrough Technologies 2025 After years of controversy, stem cells are on the cusp of cures for conditions like epilepsy and type 1 diabetes https://t.co/LSGQ98e0ny
technologyreview.com
After years of controversy, stem cells are on the cusp of cures for conditions like epilepsy and type 1 diabetes.
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Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system.
nature.com
Nature Aging - This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to...
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Study hard what interests you the most in the most undisciplined, irreverent, and original manner possible.
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Sad news for all current graduate students out there. ChatGPT pretrained on scientific papers of the last two decades can now predict the results of your study. Oops. https://t.co/mJyW0JxCn0
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