Cell Stem Cell
@CellStemCell
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A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
Cambridge, MA
Joined June 2009
Our latest issue is out! Highlights include reports on the immune response to allogeneic cell therapies in clinical trials with iPS-DA neurons and primary hypoimmune CAR-T cells, a PDAC organoid biobank that IDed use of statins in a clinical trial, & more! https://t.co/7r7yiGocKl
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There's still time to sign up for our Cell Symposium this November! We are extending our early bird registration prices through Sept 30th. See you in LA!😎
Last chance to save on registration at the upcoming Cell Symposia: Gene and cell-based therapies: Progress in clinical translation, happening November 2–4, 2025, Los Angeles, CA @CellSymposia #CSStemCells2025 @CellStemCell @CellRepMed
https://t.co/waEPTbVffk
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Online Now! Adopting novel alternative methods (NAMs) for biomedical research—What is the right approach? https://t.co/pj1Mr1vLVm
#stemcells
cell.com
The field of medical science has relied on animal models to both establish fundamental biological principles and test new drugs prior to human administration for over 100 years. Given the significant...
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Severing the scar supply line: CAR-T in chronic kidney disease
cell.com
CAR-T cell therapy is rapidly being extended to target various pathophysiological processes beyond cancer. In this issue of Cell Stem Cell, Zhao et al. engineered PDGFRβ-specific CAR-T cells in vivo...
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From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony
cell.com
While current stem cell differentiation protocols generate β cell-enriched islets that reverse hyperglycemia post-implantation, they can cause hypoglycemia. Meng et al. reconstruct endocrine subtyp...
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Engineered VTA dopaminergic neurons offer a new path to treating depression
cell.com
Dysfunction of A10 midbrain dopaminergic (mDA) neurons is linked to psychiatric disorders, such as depression. In this issue, Yan et al. present an efficient method for differentiating human plurip...
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Ready, set, but no go: Skin fat comes preloaded with waiting precursors
cell.com
Fat depots across the body dynamically tune their sizes in response to nutrient demands and nonmetabolic cues. Writing in Cell Stem Cell, Rivera-Gonzalez et al. report that skin fat, notable for its...
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Face off: Stem cell therapy versus the immune system
cell.com
As stem cell therapies make great strides in clinical trials, the challenge of immune rejection has come into a sharper focus. Several recent clinical reports provide insight into the challenges...
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Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging
cell.com
Compared with ground controls, ISS missions showed that spaceflight accelerates hallmarks of hematopoietic stem and progenitor cell (HSPC) aging, including decreased dormancy in AI-driven FUCCI2BL...
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Last chance to save on registration at the upcoming Cell Symposia: Gene and cell-based therapies: Progress in clinical translation, happening November 2–4, 2025, Los Angeles, CA @CellSymposia #CSStemCells2025 @CellStemCell @CellRepMed
https://t.co/waEPTbVffk
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Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease
cell.com
Zhao et al. identify PDGFRβ as a common surface antigen for the major ECM-producing cells including fibroblasts, pericytes, and myofibroblasts in the kidney. They further demonstrate that PDGFRβ...
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Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease
cell.com
Morizane et al. reported on the immune responses observed in an allogeneic iPSC-based cell therapy trial for Parkinson’s disease. A milder immunosuppressive regimen, compared with those used in organ...
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Multi-omic analysis reveals retinoic acid molecular drivers for dermal fibrosis and regenerative repair in the skin
cell.com
Griffin et al. utilized the established murine bleomycin skin fibrosis model to identify the fibroblast subpopulation(s) and signaling pathways responsible for skin fibrosis. Using a multi-omic...
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Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease
cell.com
Schrepfer and colleagues investigated the immune response against subpopulations of the hypoimmune, allogeneic CD19 CAR T cell product SC291 in clinical trials. Although patients mounted a rejection...
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A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy
cell.com
Gao and colleagues identify new therapeutic opportunities for pancreatic cancer via integrated pharmacogenomic analysis of organoid models, highlighting statins as effective agents to overcome...
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Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors
cell.com
Yan et al. developed a robust differentiation protocol for generating A10-like mDA neurons from hPSCs and characterized the derived cells in terms of their transcriptomic and electrophysiological...
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Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo
cell.com
Deng and colleagues developed stem cell-derived islets with controlled relative abundance of endocrine cell types, simultaneously possessing glucose-lowering and glucose-raising abilities. After...
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TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
cell.com
(Cell Stem Cell 32, 1285–1298.e1–e8; August 7, 2025)
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Online Now! A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer https://t.co/LIczoOqVjR
#stemcells
cell.com
Chan and colleagues use CRISPR screens in patient-derived tumor organoids to reveal metabolic vulnerabilities not seen in 2D and 3D spheroid models and identify potent inhibitors that target gastric...
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