Tarek
@tarek10281
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Joined October 2023
See the published version of our pre-print (original twitter thread below). https://t.co/rfl8mUecTJ
Excited to share the latest work from my lab and @em6wong led by @DanielMedinaC12 @tarek10281 @verpetrova. We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells. @MSKCancerCenter @MSK_CSCB @MSKEducation
https://t.co/JSOnogfLuC
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Excited to share the latest work from my lab and @em6wong led by @DanielMedinaC12 @tarek10281 @verpetrova. We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells. @MSKCancerCenter @MSK_CSCB @MSKEducation
https://t.co/JSOnogfLuC
biorxiv.org
Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular...
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Beyond excited to share my main postdoctoral work. We developed a robust mouse cortical organoid system, which recapitulates in vivo tempos and cellular diversity, and applied it to identify gene expression changes across subspecies during development.
biorxiv.org
Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular...
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Excited to share our latest manuscript. This was an exciting collab with the (twitter-less) Matthias Stadtfeld + Jason Mezey labs at Weill Cornell. We examined the impact of genetic variation on pathological loss of DNA methylation in naive PSCs. https://t.co/Kz3t9thMAm
biorxiv.org
Naïve pluripotent stem cells (nPSC) frequently undergo pathological and not readily reversible loss of DNA methylation marks at imprinted gene loci. This abnormality poses a hurdle for using plurip...
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Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. https://t.co/hYkW2fJ1qo
biorxiv.org
The directed differentiation of pluripotent stem cells (PSCs) from panels of genetically diverse individuals is emerging as a powerful experimental system for characterizing the impact of natural...
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Excited for this collaborative study by the twitter-less Stadtfeld group and @TommyVierbuchen reporting a new role for neuroectpderm regulator OTX2 in the specification and anteriorization of Definitive endoderm
biorxiv.org
The molecular mechanisms that drive essential developmental patterning events in the mammalian embryo remain poorly understood. To generate a conceptual framework for gene regulatory processes during...
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