Shaheen Sikandar
@ssikandar
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Assistant Professor @UCSC @UCSCScience by way of @CellStanford @UCIrvine, Breast Cancer, Metastasis, Stem Cells, Science Mom!
Bay Area
Joined February 2010
📢 Excited to share the first pre-print from our lab: Pregnancy Reduces Il33+ Hybrid Progenitor Accumulation in the Aged Mammary Gland https://t.co/SDAvAXoH2U lead by @andrewolander4 and Cynthia Ramirez
biorxiv.org
Aging increases breast cancer risk while an early first pregnancy reduces a woman’s life-long risk. Several studies have explored the effect of either aging or pregnancy on mammary epithelial cells...
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Beautiful study from @LoiSher in @Nature Parity and lactation induce T cell mediated breast cancer protection https://t.co/5Y0FGwjAFC What are the immunological underpinnings of parity and breastfeeding reducing the lifetime risk of breast cancer in women?
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Check out our recent study showing how to re-activate estrogen responses in originally hormone low/negative breast cancer cells! Shoutout to the amazing @DeeptimanChatt2 @CicconeMichael @anandan_dhivyaa!
nature.com
Nature Communications - BPTF is known to regulate chromatin accessibility and self-renewal in mammary epithelial stem cells. Here, the authors discover that BPTF inhibition delays tumor formation,...
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A fascinating study shows that the longest lived-rodent evolved a cGAS variant to boosts DNA repair while dampening inflammation. Uncoupling genome surveillance from inflammation may be the secret to longevity #aging #inflammation
science.org
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that...
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I am delighted to share this new review in @NatureCancer that I co-author with @AnqiDong18 In which we discuss the different EMT tumor states and their implications for metastasis and cancer therapy.
NEW content online! Identification, functional insights and therapeutic targeting of EMT tumour states https://t.co/1g5x4td9Vc
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Are you looking for a reliable strategy to analyze mammary tissue using whole mount images?? Well, maybe you should check MaGNet, our new computational based and user friendly approach (and you probably can adapt it to other organs as well).
link.springer.com
Journal of Mammary Gland Biology and Neoplasia - The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A...
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Excited to introduce our Cell Reports Medicine @CellRepMed @CellPressNews article with the features of overextended #healthy #lifespan vs common #chronological #time: The story of a record-breaking #supercentenarian in a world burdened by #aging-related diseases.
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Can we root out the seeds of metastasis? @LiuCluster & team @NUFeinbergMed identify a rare T cell subset that cluster circulating tumor cells to promote metastasis in breast cancer, then provide a proof-of-concept block using VLA-4 antibody in preclinical models:
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Excited to share our new preprint introducing CenSegNet, a deep learning framework for high-throughput, spatially resolved, single-cell centrosome profiling in heterogeneous tissues. Co-led by brilliant PhD students, Jiaoqi Cheng & Keqiang Fan. 1/3 https://t.co/OVzDIsGFba
biorxiv.org
Centrosome amplification (CA) is a hallmark of epithelial cancers, yet its spatial complexity and phenotypic heterogeneity remain poorly resolved due to limitations in conventional image analysis. We...
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Congratulations to the team on all their hard work on developing this first of its kind model! @Dan_Lester8 @aventura71 @psalmotoxin @WTKLAB @ShelleyBuffens1 @KYTsaiLab @LabElsaFlores @CD_AACR
⭐️The first genetically engineered endogenous cancer model in naked mole-rats 👇
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1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated.
science.org
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In...
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Excited to share our latest study in @CELL @MDAndersonNews a new single cell DNA&RNA co-assay technology (wellDR-seq) used to study the interactions of DNA copy number and gene expression during breast cancer progression led by @KaileWang @RuiYejerry
https://t.co/99NxcuhzYN
cell.com
wellDR-seq allows single-cell whole-genome and transcriptome co-profiling at scale, enabling dissections of complex relationships between copy-number alterations and gene expression that inform our...
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Congratulations @andrewolander4 , who received his NIH/NCI F31 fellowship to study how early pregnancy affects the aging of mammary epithelial cells! Earlier this year, it felt like the odds were against us, but it finally came in! 🍾 #BreastCancer #aging #stemcells
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Our new review in Trends in Cell Biology : "The Wnt–NAD⁺ axis in cancer, aging, and tissue regeneration" https://t.co/kHFrGcK3tn 👏 Kudos Lamprecht & Abu Sanad and 🙏 @KusumbeLab Apologies to colleagues not cited (journal limits) + 🙏 to colleagues, reviewers & editor.
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Excited to share our CITE-seq atlas of the aging human immune system across tissues. Great collaboration with @DonnaFarber3, @YosefLab, @teichlab, Jo Jones @Cambridge_Uni and partnership with @cziscience! https://t.co/wH1v6xMyy0
nature.com
Nature Immunology - Wells et al. profile RNA and surface protein expression to describe dominant tissue-specific effects on immune cell composition and function across lineages in the human tissues...
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Interested in the dynamics of cancer progression and persistence? Please join me, Mariam, Ken, and our fantastic speakers in Albuquerque this Dec to discuss diverse features of cancer evolution! 🧩🔎🦀
Submit an abstract by October 1 for the AACR Special Conference on Cancer Evolution (December 4-6; Albuquerque), chaired by Mariam Jamal-Hanjani, Kenneth J. Pienta, and Mara H. Sherman and held in association with #AACRCEWG. https://t.co/XWPcYIr7b5
#AACRevol25 @MaraShermanLab
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Great new work from Anthony in the lab! Continues our journey on sex differences in cancer, and now extends it to platelets! No nucleus (platelets) - still a problem in cancer - grateful to @2Scottish and all our collaborators on helping us make this happen!
We are happy to highlight a new preprint on @biorxivpreprint where we reveal a sex-specific estrogen dependent role for platelet PAR4 signaling in regulating CD8+ T cell immunity in glioblastoma. https://t.co/yFtm9OR3mz
@JusinLathia @2Scottish @CCLRI
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Any cuts to the NIH budget would stifle innovation and erode the nation's position as the global leader in biomedical research. I encourage all of our members and colleagues in the U.S. to ask their representatives to protect NIH funding: https://t.co/KxmvF95Bj1
A report from the nonpartisan Congressional Budget Office found that proposed NIH cuts could significantly lower the number of new drugs that come to market in the next three decades. Call on Congress to reject the President’s FY26 budget and #FundNIH: https://t.co/Fz88h3H6kl
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Still better than the NCI payline!
BREAKING: Harvard astronomer Avi Loeb warns aliens could attack Earth this November. The "potentially hostile" interstellar object is flying toward Earth at 60 kilometers per second. 7% chance.
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Senate HELP committee endorses @NIH budget increase, rebuking Trump administration’s proposed 40% cut. 🙏 https://t.co/TkvPZ5SP0H via @statnews
statnews.com
Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday
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