Cell Reports Medicine
@CellRepMed
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Broad-scope #OA journal from @CellPressNews publishing cutting-edge science across the spectrum of #Translational and #ClinicalResearch | Editor: @DrSaraHam
USA, NLD, CHN, GBR, BEL
Joined October 2019
Xing et al. show BRAF/MEK inhibitors induce glioma cell plasticity, upregulating PD-L1 and suppressing T cells. Artwork depicts tumour heterogeneity as flowers, with PD-L1 as florets and T cell suppression as spent heads. Cover by Yao Lulu Xing.
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Online now: MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors
cell.com
Xia et al. reveal that MjHKU4r-CoV-1 has high fusogenicity and can induce inflammatory responses in human cells. By determining the six-helix bundle (6-HB) structure of MjHKU4r-S, they clarify its...
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Online now: Computational framework for prioritizing candidate compounds overcoming the resistance of pancancer immunotherapy
cell.com
Feng et al. develop a computational framework (IGeS-BS) to recommend compounds that enhance immunotherapy responses and generate an immuno-boosting landscape for more than 10,000 compounds and 13...
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Online now: Lassa fever in African green monkeys: Clinical disease and fatal outcome are associated with systemic viral dissemination and inflammation
cell.com
The worldwide shortage of Asian-origin macaques for research has hindered progress on medical countermeasures for LASV and other high-consequence pathogens. Cross et al. assessed the pathogenic...
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Online now: Cardiometabolic disease and cardio-oncology: Insights from iPSC models and tissue engineering
cell.com
Kojic et al. explore the intersection of cardio-oncology and cardiometabolic disease. Using iPSC-based models, they highlight shared mechanisms such as metabolic reprogramming and inflammation,...
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Online now: Identification of immune signatures associated with both SARS-CoV-2 infection and lung transplantation
cell.com
Hoffmann et al. assess the circulating immune system in lung-transplantation patients with COVID-19-associated lung injury (CALI) and other COVID-19 convalescent patients. They demonstrate that CALI...
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Online now: High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis
cell.com
Huang et al. demonstrate that elevated circulating palmitic acid (PA) induces hypercoagulability by inhibiting activated protein C (APC) and enhancing platelet activation. High-fat diet increases gut...
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Online now: Proteogenomic characterization unveils biomarkers associated with chemoresistance in muscle-invasive bladder cancer
cell.com
Holt et al. perform proteogenomic characterization of 46 pre- and 14 post-treatment muscle-invasive bladder tumors. Multi-omics clustering separates chemotherapy-sensitive and -resistant tumors....
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Online now: Comorbidity analysis and clustering of endometriosis patients using electronic health records
cell.com
Khan et al. use large-scale electronic health records to analyze comorbidities and patient subtypes in endometriosis. They identify reproducible associations across institutions and uncover clusters...
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Online now: Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome
cell.com
The symptoms of any illness cause suffering and are the prime targets for therapy. A detailed consideration of the neurological, immunological, metabolic, and vascular mechanisms that generate the...
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Looking forward to @UCIrvine Lisa Wagar’s talk “Predicting immunogenicity using human immune organoids”@CellSymposia #CSStemCells25. Want to join her? Submit an abstract before August 1 to be considered for a poster or short talk
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Online now: BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma
cell.com
Guo et al. perform a genome-wide CRISPR screen and identify BRD9 as a key regulator of tumor cell resistance to oncolytic virotherapy. BRD9 inhibition enhances ICD and promotes antitumor activity in...
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Online now: Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity
cell.com
Ahn et al. characterize the function of an IL-2+IL-10 tumor-targeted fusion protein. This molecule uncouples IL-2 inflammatory toxicity from potent adaptive anti-tumor immune activation by virtue of...
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Collection highlight from @CellRepMed: Single-cut gene therapy in a one-step generated rhesus monkey model of Duchenne muscular dystrophy.
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Online now: A human milk oligosaccharide alters the microbiome, circulating hormones, and metabolites in a randomized controlled trial of older adults
cell.com
Carter et al. show that 2′-fucosyllactose, a human milk oligosaccharide, increases Bifidobacterium in older adults' gut microbiomes, associated with elevated HDL cholesterol, insulin, and FGF21...
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Online now: Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis
cell.com
Pinho et al. show that HR+ breast cancer patients with lymph node metastasis have an impaired antitumor CD8 immune response, with less frequency of tumor-reactive TILs. Yet, early-stage patients...
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Online now: Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer
cell.com
Huang et al. identify a distinct IRF1+ interferon-licensed CAF subset (ilCAF) in rectal cancer that reshapes the immune microenvironment and enhances response to neoadjuvant radiotherapy. Activation...
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Online now: Imeglimin suppresses glucagon secretion and induces a loss of α cell identity
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Online now: Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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Online now: Synergically enhanced anti-tumor immunity of in vivo panCAR by circRNA vaccine boosting
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Online now: Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy
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