Cell Reports Medicine
@CellRepMed
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Broad-scope #OA journal from @CellPressNews publishing cutting-edge science across the spectrum of #Translational and #ClinicalResearch | Editor: @DrSaraHam
USA, NLD, CHN, GBR, BEL
Joined October 2019
Xing et al. show BRAF/MEK inhibitors induce glioma cell plasticity, upregulating PD-L1 and suppressing T cells. Artwork depicts tumour heterogeneity as flowers, with PD-L1 as florets and T cell suppression as spent heads. Cover by Yao Lulu Xing.
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Online now: Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies
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Online now: IgA2+ B cells and IgA2 anti-dsDNA antibodies are selectively targeted by belimumab after rituximab therapy in systemic lupus erythematosus
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Connect with us on LinkedIn for curated content, author interviews, and information on editors that may be visiting your city!
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Online now: Neolactotetraosylceramide enables urinary detection of bladder cancer
cell.com
Moreira et al. show that the glycosphingolipid nLc4 is increased in bladder cancer tissue and patients’ urine. nLc4 is selectively expressed in tumor cells and secreted via extracellular vesicles....
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Interested in sharing your research at our Cell Symposium in LA?.We're keeping the abstract submission system open for poster and short talk submissions until August 1, 2025. Submit here: @CellSymposia #CSStemCells25
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Online now: Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
cell.com
Corti et al. leverage patient hiPSC-derived retinal organoids and retina-on-chip systems to replicate key CLN2 retinal pathologies, including lipofuscin accumulation and cone dysfunction. AAV9-medi...
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Online now: Deep learning for detection and diagnosis of intrathoracic lymphadenopathy from endobronchial ultrasound multimodal videos: A multi-center study
cell.com
Chen et al. develop AI-CEMA, a deep learning system for CP-EBUS multimodal video analysis that automatically selects representative images, identifies lymph nodes, and demonstrates expert-level...
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Online now: TME-guided deep learning predicts chemotherapy and immunotherapy response in gastric cancer with attention-enhanced residual Swin Transformer
cell.com
Sang et al. develop a multitask deep learning model, the residual Swin Transformer network, from radiographic image and clinical data, which allows non-invasive evaluation of adjuvant chemotherapy...
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Online now: Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners
cell.com
Sun et al. identify PGK1 as a key metabolic driver of diabetic kidney disease (DKD). PGK1 promotes inflammation via both enzymatic and non-enzymatic mechanisms. Targeting PGK1 with small-molecule...
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Online now: CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors—A narrative review
cell.com
In this review, Knoedler et al. highlight the potential of integrating CAR-T cell therapy with reconstructive surgery for peripheral solid tumors. Combining advanced cellular immunotherapy with...
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Online now: Moving cellular therapies to the front line for Ph+ B cell acute lymphoblastic leukemia
cell.com
Chemotherapy-free regimens have gained increasing attention as frontline treatments for B cell acute lymphoblastic leukemia (B-ALL) due to the limitations of chemotherapy. Zhang and colleagues...
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Online now: The expanding benefits of GLP-1 medicines
cell.com
GLP-1 medicines, initially developed for blood glucose and weight control, improve outcomes in people with cardiovascular, kidney, liver, arthritis, and sleep apnea disorders, actions mediated in...
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Online now: Intrinsic chicory root fibers modulate colonic microbial butyrate-producing pathways and improve insulin sensitivity in individuals with obesity
cell.com
Omary et al. show that 12-week supplementation with intrinsic chicory root fiber improves insulin sensitivity and cardiometabolic health. These benefits are accompanied by a functional shift toward a...
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Online now: Metabolic fingerprinting enables rapid, label-free histopathology in gastric cancer diagnosis and prognostic prediction
cell.com
Teng et al. develop a rapid and label-free histopathological method based on metabolic fingerprinting of FFPE tissue using nanoparticle-enhanced LDI-MS. The efficient method enables diagnosis,...
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Online now: RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations
cell.com
Li et al. find that KRAS-mutant LUAD resists immunotherapy due to RANKL-driven immunosuppression via PD-L1/CXCL9-11 downregulation and reduces CD8+ T cells. RANKL inhibition combined with PD-1...
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Online now: Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma
cell.com
Chen et al. develop a chlorin e6 derivative-mediated PDT combined with immunotherapy, incorporating PDT, a STING agonist, and anti-LAG3. This approach optimizes the tumor immune microenvironment by...
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Online now: Endoscopic healing in pediatric IBD perpetuates a persistent signature defined by Th17 cells with molecular and microbial drivers of disease
cell.com
Persistent inflammation compromises long-lasting remission in patients with inflammatory bowel disease (IBD). Siebert et al. identify a transcriptomic signature of residual disease in intestinal...
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Final call: Abstracts for Gene and cell-based therapies are due tomorrow Friday, July 18. Submit now for a chance to present your work at this symposium in LA! @CellSymposia #CSStemCells2025.
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Online now: A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer
cell.com
Dilasser et al. identified A41 as a specific RAC inhibitor. Chronic administration of A41 exhibits anti-metastatic effects in experimental models of invasive cancers (breast and colorectal cancers),...
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Online now: Perioperative administration of CBM588 in colorectal cancer radical surgery: A single-center, randomized controlled trial
cell.com
Yang et al. conduct a phase 4, open-label, randomized controlled trial and report effects of perioperative administration of CBM588 in patients undergoing colorectal cancer radical surgery. CBM588...
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