Cell Reports Medicine
@CellRepMed
Followers
19K
Following
652
Media
228
Statuses
3K
Broad-scope #OA journal from @CellPressNews publishing cutting-edge science across the spectrum of #Translational and #ClinicalResearch | Editor: @DrSaraHam
USA, NLD, CHN, GBR, BEL
Joined October 2019
On the Cover: A gardener removes weeds among flowers—just like therapies targeting the tumour microenvironment can eliminate cancer cells while sparing healthy ones. Dive into our special issue for expert reviews on immune cell targeting in cancer! Artwork by Justine Reimand.
0
2
4
Online now: Comparative humoral profiles in mpox cases, survivors, and vaccinated individuals reveal correlates of protection against MPXV
cell.com
Wang et al. compare humoral profiles in mpox patients, convalescents, and vaccinated individuals, identifying dominant MPXV-neutralizing targets and defining antigenic and demographic correlates of...
0
0
0
Check out the speakers for @CellSymposia Taking programmed cell death from mechanisms to interventions, including keynotes @dixitvishva, Douglas Green, & @WuLabHarvard. View the full lineup: https://t.co/jXUbjw22hU
#CSCellDeath26
0
0
0
Online now: A multimodal synergistic model for personalized neoadjuvant immunochemotherapy in esophageal cancer
cell.com
Zhao et al. develop a multimodal deep learning framework, eSPARK, to accurately predict pathological response to neoadjuvant immunochemotherapy in locally advanced esophageal carcinoma. The model...
0
0
2
Online now: Tegileridine for moderate-to-severe acute pain following abdominal surgery: A randomized, double-blind, phase 3 clinical trial
cell.com
Wang et al. demonstrate the clinical efficacy of tegileridine, an MOR-biased agonist, which is comparable to morphine. They provide data on analgesic effects of tegileridine in vivo (in rats) and in...
0
0
0
Online now: Locoregional gemcitabine plus surufatinib and camrelizumab in FGFR2-non-altered intrahepatic cholangiocarcinoma
cell.com
In a phase 2 trial, Guo et al. report that combining locoregional gemcitabine with camrelizumab and surufatinib demonstrates promising efficacy and manageable safety in intrahepatic cholangiocarcin...
0
0
1
Online now: An integrated language-vision foundation model for conversational diagnostics and triaging in primary eye care
cell.com
Soh et al. develop Meta-EyeFM, an integrated language-vision foundation model for conversational diagnostics and triaging in primary eye care. A key innovation of Meta-EyeFM lies in the introduction...
0
0
0
Online now: Frontoparietal network mediates the antidepressant effects of accelerated iTBS and cTBS: TMS-EEG study
cell.com
Che et al. explore how a-iTBS and a-cTBS treat medication-resistant depression. Both treatments restore abnormal frontoparietal network excitability. It further identifies the left inferior parietal...
0
0
0
Online now: Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer
cell.com
Chen et al. identify TET3-mediated hypomethylation of the Otx2 super-enhancer as a critical driver of G3-MB. Disrupting this axis with LNP-delivered siTET3 effectively suppresses tumor growth,...
0
1
4
Online now: Optimal post-treatment surveillance strategy for human papillomavirus-positive oropharyngeal cancer
cell.com
Cao et al. propose the risk-adapted surveillance strategies for human papillomavirus-positive oropharyngeal cancer that are more effective and cost-efficient than current guidelines, enabling...
0
1
1
Online now: A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy
cell.com
Illiano et al. apply a multi-omics approach to study the effects of post-SG dietary protein on host metabolism in mice. Counter to current practice, following SG, they find that a low-protein,...
0
0
1
Online now: Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy
cell.com
Wang et al. identify three molecular subtypes of hepatocellular carcinoma with strong linkage to liver epithelial lineage, distinct immune phenotypes, and different clinical responses to immunother...
0
2
1
Online now: Complete neutralizing antibody evasion by serodivergent non-mammalian AAVs enables gene therapy redosing
cell.com
Loeb et al. develop an immune-evasive gene therapy vector derived from Muscovy duck, termed AAV.div3A. Rational engineering yields a liver-detargeted variant with enhanced transduction in the heart...
0
3
5
Online now: The effectiveness of large language models in medical AI research for physicians: A randomized controlled trial
cell.com
Shang et al. show that LLMs effectively assist physicians in overcoming the technical barriers related to the design, execution, and reporting of medical AI projects, raising completion from 25.0% to...
0
0
0
Online now: A triple-action PROTAC for wild-type p53 cancer therapy
cell.com
Bird et al. report that TAPTAC1, a triple-action PROTAC, inhibits HDM2 and HDMX to maximally reactivate p53 while hijacking HDM2 to degrade oncogenic BET proteins. TAPTAC1 achieves potent, multiagent...
0
1
1
Online now: L-Phenylalanine is a metabolic checkpoint of human Th2 cells
cell.com
Kulkarni et al. show that L-phenylalanine reprograms energy metabolism and restrains growth and differentiation of human Th2 cells. Patients with severe allergic diseases feature reduced L-phenylal...
0
0
1
Online now: Multi-center benchmarking of large language models for clinical decision support in lung cancer screening
cell.com
Duan et al. benchmark six large language models using multi-center real-world LDCT reports for lung cancer screening. GPT-4 leads in accuracy, while Claude 3 Opus excels in readability. Exploratory...
0
0
0
Online now: Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis
cell.com
Yao et al. identify that IL-17C in peritoneal fluid drives endometriosis-associated carcinogenesis via IL-17RE/PI3K-mediated EMT. They demonstrate that blocking IL-17C-IL-17RE signaling suppresses...
0
3
7
Online now: Nonsense-mediated mRNA decay inhibits TRAF6-dependent anti-tumor immunity in colorectal cancer
cell.com
Wang et al. demonstrate that nonsense-mediated mRNA decay (NMD) is abnormally activated in CRC. Inhibiting NMD remodels the tumor microenvironment by activating the TRAF6-TBK1 axis and boosting CD8+...
0
6
14
Online now: Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury
cell.com
Zhou et al. show that activation of Ngn2 and Isl1 enabled reactive astrocytes to convert into neurons, which promotes functional recovery after spinal cord injury, with new neurons forming synaptic...
0
0
0
Online now: Precision prediction of venetoclax-azacitidine treatment efficacy in acute myeloid leukemia via integrative drug screening and machine learning
cell.com
Jin et al. integrate drug sensitivity testing, transcriptomics, and functional assays to uncover key determinants of venetoclax-azacitidine (VEN/AZA) response in AML. They develop an eight-gene model...
0
1
5