Rishab Ramapriyan, MD
@rishabrama
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Neurosurgery Resident @PennNSG | MD @HarvardMed | BS @RiceUniversity | Passionate about brain tumors, immunotherapy, cell therapy, bioethics
Boston, MA
Joined September 2013
🚨1/8 Excited to share the final version of our #meningioma #mesothelin #CART-cell paper, now published @NeuroOnc with corrected proofs! This preclinical work lays the foundation for applying CAR T-cell therapy to aggressive and treatment-refractory meningiomas. Highlights ⬇️
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RT @PennNSG: "I think Penn is probably one of the best balanced programs in the country.". Hear from @JGolubovsky as he explains the #neuro….
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RT @BLLPHD: Optimal Pairing of Binder and Costimulatory Domains Improves Dual CAR T Cell Efficacy - Targeting both CD19 and CD22 with optim….
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RT @AANSNeuro: In honor of #NeurosurgeryAwarenessMonth, we're thrilled to highlight how one seed of support can lead to breakthrough innova….
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RT @EricTopol: New @Nature .The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depleti….
nature.com
Nature - Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the...
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RT @EricTopol: Our brain-immune system axis has recently has some fascinating new findings.Here is one summarized.M….
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RT @CIR_AACR: Priority Brief: Secretion of a VEGF-Blocking scFv Enhances CAR T-cell Potency @SupperValentina @Mark….
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RT @NewYorker: How biohackers are working to extend the human lifespan and get rich doing it.
newyorker.com
As researchers work to make death optional, investors see a chance for huge returns. But has the human body already reached its limits?
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RT @LabWaggoner: Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellul….
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RT @TheLizArmy: ✔️Touring drummer at 17.✔️Community college at 25.✔️Brain cancer at 29.Advocate. Researcher. Co-author. Now I’m finally go….
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RT @davidrliu: Today in @CellCellPress we report the use of prime editing to correct several mutations that cause alternating hemiplegia of….
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RT @BLLPHD: 15 years ago today, patient #1 on @PennMedicine @PennCancer CART19 trial received his first infusion. Then, remarkable things….
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Congrats @RuchitVP on this significant study which elucidates how copy number alterations can guide the classification, prognostication, and treatment of meningiomas, especially those that are recurrent and aggressive.
Taking a minute to share more info on our latest from @wenyalindabi lab and @MGBneurosurgery out now @NatureComms.We used whole genome microarray data in #meningioma to dissect the role of CNAs, their phenotype, and implications on risk stratification.
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Interesting to see how palm oil-based high fat diet protected mice from obesity-driven tumorigenesis and immune dysfunction. Wondering if we can see similar effects in non-obese mice with tumors. Thoughts @nicknorwitz ? An exciting example of how diet-based interventions can.
The source of dietary fat influences anti-tumour immunity in obese mice
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RT @vincentzliu: For innate immune cells, the lack of diverse receptor rearrangements has prevented the study of clonal evolution of the in….
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Congrats @RuchitaKothari_ and the authors on this impactful study that identifies a novel basic science discovery of brain inflammation mechanisms post-stroke but also provides a incredibly exciting translational angle showing how targeting Mrgprb2 can prevent/reverse post-stroke.
Very excited to share our work in @CellCellPress. Here, we propose that meningeal mast cells regulate brain inflammation after stroke by coordinating immune infiltration from the skull bone marrow, through the meninges, and into the brain!.
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8/8 Our findings provide a strong rationale for the development of new meningioma clinical trials investigating the effects of mesothelin-directed CAR T-cell therapy. Check out the full paper:
academic.oup.com
AbstractBackground. Meningioma is the most common primary CNS tumor, with high-grade cases exhibiting aggressive behavior, frequent recurrence, and poor pr
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7/8 This work would not have been possible without the award-winning mentorship of @BryanDChoi as well as many others who supported my scholarship @harvardmed including @BobCarterMD @BrianNahed @EAChiocca. I thank our many collaborators and the @NREFORG for supporting this work.
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6/8 And here is a time-lapse video showing rapid cytotoxcity of mesothelin CAR T-cells (red) against human anaplastic (Grade 3) meningioma cells (green).
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