🔥 Why I’m Committed to Making Metabolic Health Mainstream (in 2 min) 🔥. From a young age, I was fascinated by the wonders of biology, but it was a personal health crisis that truly defined my mission: to Make Metabolic Health Mainstream. After battling severe inflammatory

6/6) Stimulated? Curious? Ready to learn more? The rest of this letter (link below) is jam-packed with value! We will resolve this story by exploring:.👉How blue light directly causes mitochondrial fragmentation in the eye. 👉Unification: How 2 seemingly separate issues — sleep

5/6) Now, before we extrude from the brain and discuss the impact of blue light on mitochondrial dynamics inside the eye, a Special Announcement. I want to give credit where credit is due. Some of the ideas and insights you’ll read in the rest of today’s letter were inspired by

4/6) In a phrase: These data suggest mitochondrial dynamics are the cause and consequence of sleep.

3/6) Why does this matter?. Fusion promotes the sharing of resources throughout mitochondrial networks and helps maintain metabolic efficiency. Fission, on the other hand, allows cells to isolate and remove damaged mitochondria. Both are essential—but they must happen at the

2/6) The Brain: Light and the Sleep Drive. A recent paper in @Nature reframes how we understand sleep pressure—the biological drive to sleep that builds the longer we’re awake—not through melatonin, but through mitochondrial choreography. The researchers found that waking and

A New Perspective on Sleep: Mitochondria Dance to the Rhythm of the Sun (🔗 in 6/6).🚨Q&A with the first author of the new @Nature paper.🚨Book Giveaway (@hubermanlab) in 5/6 . 1/6) The sun—our oldest biological partner—does more than warm our skin or grow our food. Light is the

And as always, you can find the written breakdowns, references, and more information at . I'll also just take a moment to say THANKS! It's been an unprecedented period of growth for the Newsletter and YouTube channel -- all the credit to your support!

This NEW Fat-Burning Fiber Mimics Keto—And You’ve Never Heard of It (full video for @X). New research published in @Cell_Metabolism reveals that this specific fat-burning fiber, partially mimics the effects of a ketogenic diet and can contribute to weight loss. This isn't your

4/4) In the rest of today’s letter (🔗below), we walk you through the most compelling patterns—and how we might use them for smarter aging. We review:.👉The Age of Oxidative Stress.👉Anabolic Resistance After 60.👉Huh, Aging Isn’t Sexist?.👉Changes in Fatty Acid Metabolism.👉Why

3/4) Rather than sorting molecules by function, the researchers grouped them by how their activity changed over time. For example, Cluster 4 shows a distinct drop-off post-age 60. Each color in their charts represents a different “ome,” and together, they paint a vivid picture:

2/4) The research was conducted by the world-renowned Snyder Lab at Stanford, pioneers in “longitudinal multiomics.” This approach combines various “omes”—like the genome, proteome, transcriptome, and microbiome—to form a detailed picture of how an organism functions at the

Two Waves of Aging: Molecular Shifts at 44 and 60.(🔗 at the end). 1/4) Aging is not a linear process. Intuitively, maybe you’ve sensed this. But researchers at @Stanford has now revealed—at an astonishing level of molecular detail—how aging unfolds. Their key finding: aging

RT @AKoutnik: 🚨💉Chronic, IRREVERSIBLE metabolic disease, often diagnosed in childhood. 🤔Credit to @nicknorwitz: He challenged me and the….

3/3) Finally, THIS is what control should look like for every patient. Andrew has maintained an A1c of 5.5% for >12 years. But even with the best 'standard of care,' <1% of T1D patients achieve normal blood glucose. 👉The >99 % should be in the <1%

2/3) Now, here's the full interview with Dr @AKoutnik about why the Diabetes Status Quo is unacceptable. And stay tuned for part 2. which might have you in tears by the end (not kidding). I left with goosebumps.

The Diabetes Status Quo is Unacceptable! Dr. @AKoutnik Speaks Out. In this powerful and personal conversation, Dr. Andrew Koutnik, PhD shares how being diagnosed with Type 1 Diabetes as a teenager radically shaped his life and scientific path. What started as a personal health

Science isn’t a democracy. Truth doesn’t need a majority vote. Stand by your interpretation of the data — even, and especially, when it means being the minority fool. That’s courage. (Strike that -- I'll accept this vote #StayCurious 😜)

5/5) Now, if you want more about aging, visceral fat, and what natural compounds might act on this newly discovered LIFR-STAT3 pathway to block adipogenesis, read today’s StayCurious Metabolism Newsletter. I aim to make it worth your time!

4/5) Ultimately, the researchers revealed that the mechanism was related to the LIFR-STAT3 pathway. Importantly…. (1) This LIFR-STAT3 pathway is also active in the fat of middle-aged humans. You can see on the left a graph of these LIFR fat cells and how they increase, rather

3/5) Well, now I need to explain two ways in which fat grows. 👉Hypertrophy: Mature, existing fat cells can grow larger. 👉Adipogenesis: New fat cells grow from precursor stem cells called Adipose Progenitor Cells (APCs). Now here’s the funny thing about APCs as stem cells: