Nathaniel Snyder
@mzspectrum
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Have mass, give charge, will measure. Roosevelt-UMCP-NIH-Penn-Drexel-Temple. Addicted to coffee and new data.
Philadelphia, PA
Joined March 2016
Congrats Kate Korobkina et al for our @NatMetabolism paper online now showing that in brown fatβa thermogenic tissue famous for generating vast amounts of acetyl-CoA in mitochondriaβcytosolic acetyl-CoA synthesis also mattersβ¦ALOT. Find out why here: https://t.co/jTZrpFA8uC
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Great opportunity for an metabolomics expert and manager to lead the Platform at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen. Thanks for RT! @MetabolomicsSoc @SocietyNordic @JuliJivanisevic
π ππ ππ«π π‘π’π«π’π§π ππ§ ππ±π©ππ«π’ππ§πππ π¦πππππ¨π₯π¨π¦π’ππ¬ ππ±π©ππ«π ππ§π π©ππ¨π©π₯π π¦ππ§ππ ππ« ππ¨ π₯πππ ππ‘π π¦πππππ¨π₯π¨π¦π’ππ¬ π©π₯ππππ¨π«π¦ π©βπ¬ As one of five enabling biology and technology platforms, the
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I am excited to share our new preprint on lactate metabolism! This has been a tremendous effort by my lab, @StavrosDrakos and @RutterLab to integrate biochemical and physiological data to understand the mechanism of lactate metabolism in the heart. https://t.co/B8hADFx3dT. .
biorxiv.org
Lactate is the highest turnover circulating metabolite in mammals. While traditionally viewed as a waste product, lactate is an important energy source for many organs, but first must be oxidized to...
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A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA https://t.co/0W2eutCiJ5
#biorxiv_biochem
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π’Thrilled to announce that I will start independent position at Fox Chase Cancer Center Jan 2025 @CeiFccc @FoxChaseCancer. The Luo lab will study novel #mechanisms controlling stem cell fate choices in normal and diseases. π§¬π¬ππ©Έ#RNA #RNAmodifications #HSC #leukemia (1/4)
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Soooo excited and honored to receive the @AACR - Anna D. Barker fellowship that will support my research on uncovering a new link between #metabolism and #epigenetics in #PDAC. Many thanks to my amazing mentors @WellenLab @mzspectrum for making this possible. Stay tuned!!!
We congratulate Christina Demetriadou, PhD, recipient of the 2024 AACR Anna D. Barker Basic Cancer Research Fellowship. We look forward to her findings on the nuclear role of branched chain amino acid catabolism in pancreatic cancer growth and treatment resistance. @ChristiDemet
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My baby girl came on Monday night and closing the week with a first author paper from @DrRGJonesLab ! What a week!! Many thanks to everyone for all the efforts to get this paper out!!
Kaymak, Watson @DrRGJonesLab @VAInstitute and colleagues show that production of cytosolic acetyl-CoA by ACLY and ACSS2 links CD8 T cell metabolic state and effector function through effects on #chromatin accessibility. https://t.co/SXe4rq4iCD
#Metabolism #LymphocyteBiology
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Its crazy that the first lab to do inVivo metabolic labeling proteomics by feeding mice heavy isotope AAs called it SILAM when the name Miceotopes was sitting right there
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We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first!
biorxiv.org
Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant...
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New from @DanKellyPennCVI How do SGLT-2 inhibitors work? Some intriguing SGLT2 independent actions in mice with HFrEF @CircRes
ahajournals.org
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PhD students thinking about academic postdocs-after some exciting grant news, my lab is hiring! We love all things cellular metabolism, and projects are tailored to fit individual interests. Opportunities exist for co-mentorship with other labs. More info:
airdlab.com
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Dr. Erica Golemis, a trailblazer in cancer research, has been appointed as the Senior Associate Dean of Research. We are so proud to have her outstanding leadership shape the future of research at #TempleMed.
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Poster sessions are the real reason for conferences.
Last week @BagPhos walked up to my poster, saw a reaction I was struggling to get useful yields on for over a month, spent all of maybe 5 seconds thinking about it, rattled off a list of reagents, sent me a citation and then confidently said "that'll work"....
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Meet Nathaniel W. Snyder @mzspectrum Winner of the 2024 Chemical Research in Toxicology Young Investigator Award! Read our interview here π https://t.co/tF0fwlQ1QS
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Also: new murine breast cancer model immunotherapy data - nice additive effects of combining T cell checkpoint blockade + i.t. MPLA/CoA (former is clinically approved TLR4 agonist). Now working on a better way to get CoA into tumors to reprogram TAMs... (7/x)
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Shoutout @mzspectrum & Co for employing their VB5 Stable Isotope Labeling with Essential nutrients in Cell culture (SILEC) method to trace exogenous unlabeled CoA into macrophages. Provides compelling evidence for a mac CoA uptake mechanism. (2/x)
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Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x)
biorxiv.org
Toll-like receptor (TLR)-dependent macrophage responses rely on acute increases in oxidative mitochondrial glucose metabolism that epigenetically support rapid proinflammatory transcriptional...
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@NeedhiBhalla I have lately been explicitly saying Iβm a basic scientist and proud of it at the end of my talks. Iβve had a couple trainees tell me they were encouraged by that.
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Check out our latest preprint @biorxivpreprint led by the newly minted Dr. @JTylerHagen π In it, we investigate the peculiar bioenergetic phenotype of AML with the goal of identifying cancer-cell intrinsic mitochondrial physiology potentially actionable to treat the disease.
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Hi all, we are looking to add some lab members at various levels like technician, grad student, postdoc, senior scientist. Check out our projects here: https://t.co/vih2wod6ST please retweet
gruberlabutsw.org
Joshua Gruber's laboratory webpage at UT Southwestern (UTSW) Medical Center
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