Irem:)
@kaymakirrm
Followers
270
Following
4K
Media
30
Statuses
922
Postdoc@UniManchester, passionate abt metabolism and immunity
Manchester, England
Joined February 2016
https://t.co/c0RCNohwRk Happy to share our work from @DrRGJonesLab checking the impact of different nutrients on CD8+ effector function in more physiological conditions🍺🍺Thanks everyone involved especially my great colleague @KawaZbozowa 💪was a big teamwork #tracerteam
9
14
87
New! Online now: Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase https://t.co/R7UNOCjnn5
1
25
77
ACLY and ACSS2 link nutrient-dependent #chromatin accessibility to CD8 T cell effector responses, say Irem Kaymak (@kaymakirrm), McLane Watson, Russell Jones @DrRGJonesLab @VAInstitute and colleagues: https://t.co/rZDRI1QHzW
#Metabolism #LymphocyteBiology #InfectiousDisease
0
4
9
My baby girl came on Monday night and closing the week with a first author paper from @DrRGJonesLab ! What a week!! Many thanks to everyone for all the efforts to get this paper out!!
Kaymak, Watson @DrRGJonesLab @VAInstitute and colleagues show that production of cytosolic acetyl-CoA by ACLY and ACSS2 links CD8 T cell metabolic state and effector function through effects on #chromatin accessibility. https://t.co/SXe4rq4iCD
#Metabolism #LymphocyteBiology
11
3
44
Happy to share our new paper in print today in @ScienceAdvances exploring nutrient utilization by CD8 T effector cells in vivo using infusion of 13C tracers. Great work by Eric Ma, Mike Dahabieh and collaborators at @VAInstitute and @AgiosPharma.
science.org
Interrogating dynamics of fuel utilization by CD8 T cells in vivo reveals metabolic checkpoints for immune function in vivo.
14
39
149
This is very cool indeed!!
This is so cool. A gut-derived hormone regulates cholesterol metabolism:
0
0
2
Statins aggravate insulin resistance through reduced blood GLP-1 levels in a microbiota-dependent manner #diabetes #hyperglycemia #microbiome @Cell_Metabolism
cell.com
Statins are common cholesterol-lowering drugs, but the mechanism of statin-induced hyperglycemia is unclear. Here, She et al. demonstrate the function of gut microbiota-BA axis in this process. Their...
2
8
42
Looking forward to reading this:)
I am excited to share our @NatureCancer review on the role of #lipid and #fattyacid #metabolism in #cancer progression and #metastasis! @MetaboholicsLab @adrianobcfilho @almut_schulze @DKFZ 🥳 https://t.co/M7XD2Qvrd4
0
0
3
Waowwwwww!!!
Happy to announce that our @VAInstitute modified IMDM medium (VIM) is now available from Wisent
0
0
1
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate: Cell Metabolism
cell.com
The effects and pathological mechanisms of high dietary fructose in HCC remain unclear. Zhou et al. show that hyper-O-GlcNAcylation induced by microbial acetate contributes to HCC progression in a...
2
19
69
A systematic exploration of Trm metabolism reveals how to leverage fueling memory CD8+ T cell formation in the context of acute infection and antitumour responses @Nature @MReinaCampos
@GoldrathLab
https://t.co/eM8ASS9vLb
nature.com
Nature - A study describes the metabolic adaptations supporting differentiation, survival and function of tissue-resident memory CD8+ T cells and how to leverage them to enhance immunity against...
0
27
75
Incredibly proud of a new study, led by brilliant Naomi Goldman, demonstrating for the first time that the intrinsically disordered domain of TCF-1 is critical for T cells. We are grateful to exceptional collaboration in @vahedilab and beyond https://t.co/LZxCNFKbmr
13
40
186
Congratulations @KawaZbozowa and @jlongo92 great to see it is out!!👏👏👏
Happy to share our new paper out in @ImmunityCP on ketolysis as a metabolic driver of CD8 T cell responses. Great work spearheaded by @KawaZbozowa and @jlongo92 and fun collaboration with @ketonemics. @VAIMetabolism @VAInstitute
0
0
3
New! Online now: Acetate controls endothelial-to-mesenchymal transition
cell.com
Endothelial-to-mesenchymal transition (EndMT) is initiated by activation of endothelial TGF-β signaling. Induction of EndMT results in increased ACSS2-dependent Ac-CoA synthesis from pyruvate-derived...
1
37
106
Great study focusing on metabolic landscape of male mouse gut!
nature.com
Nature Metabolism - Anatomically resolved maps of small molecules along the gut of colonized and germ-free mice reveal distinct spatial patterns throughout the gut. These patterns can, in part, be...
0
0
0
Go and see @madeleinehurry's awesome talk on gut-brain axis! #pint23
🧠 🚨 THREE DAYS TO GO!!! 🚨 🍺 #pint23 is returning to Manchester this Monday and tickets are getting snapped up faster than free crisps at the bar 🤯 Here’s another events spotlight to help you choose where you should be spending your next 3 weekday evenings… 🧵 ⬇️
0
0
4
Commentary on Turkish election effects on education! We could have woken up to a better morning today😔😔
nature.com
Nature - Abolishing the council that controls the universities would allow higher education to finally blossom.
0
0
0
Congratulations to Shelby and @DrRGJonesLab 👏👏👏
Online Now: LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation
0
0
4
Was great to be involved in this study from @Conorisco and @ProfJudiAllen group @LydiaBeckerIII. Congratulations 👏👏👏
So excited that Conor's paper is out! Congrats @Conorisco
@Lili_Zhang_Dr
@JamesEP_ and more. Thanks to our funders - Wellcome & for this paper mostly MRC-UK. Some of my thoughts in the following thread.
0
1
4