Andrew Leduc
@_AndrewLeduc
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Post-doc @slavovlab Interests: Non-canonical protein sequences Protein degradation Single cell analysis
Boston, MA
Joined February 2020
RT @maxdkozlov: The NIH budget would INCREASE by $400m — not slashed by 40%, as Trump proposed — in a proposal by Senate appropriators, say….
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RT @JEFworks: In this interview, I explain how university research, when funded by independent #NIH #NSF federal grants, brings oversight t….
hub.jhu.edu
Hopkins researcher Jean Fan and her team create open-source tools that help bridge the gap between academic discoveries and life-saving treatments. Cuts to federal funding threaten to break this...
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RT @DKThomp: One lesson of DOGE is that a lot of federal govt spending is sent to old ppl (social security, Medicare) and affluent individu….
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RT @mitchguttman: Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPr….
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It's that time again, where finishing the last 5% of a paper means your productivity turns to snails pace.
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RT @slavov_n: @LabWelch Andrew @_AndrewLeduc talked about measuring protein synthesis and degradation rates in single cells at @SCP_meeting….
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RT @MoKhalilLab: We traveled to DC to talk to Congressional Staffers about the impact of @NIH @NIBIBgov funding. It enables us to develop s….
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RT @anshulkundaje: @RyanMorey Possibly. I wanted to simply clarify that in compbio the fundamental problem is often the opposite - that ear….
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RT @anshulkundaje: For biological data, if you don't have deep expertise in this low value work called data cleaning, u r lacking a fundame….
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RT @anshulkundaje: Practically useful & biologically aligned benchmarks such as this one from @pkoo562 lab consistently show that all the o….
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“Inaccurate energetics are evidenced by the inability of AlphaFold3 sampling to reproduce experimentally derived ensembles. Physics-based evaluation identified system-wide limitations in AlphaFold’s ability to make physically accurate predictions.”
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RT @slavov_n: “Inaccurate energetics are evidenced by the inability of AlphaFold3 sampling to reproduce experimentally derived ensembles.….
biorxiv.org
Deep learning has revolutionized protein structural prediction, with function prediction on the horizon. Because biomolecular properties emerge from atomic-level interactions and their energetics,...
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Funny quote from a conversation with a friend at lunch who accidentally took an interview from a biotech company founded by a 20 year old Thiel fellow:. "Silicon valley didn't learn from Elizabeth Holmes, they actively doubled down.".
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RT @anshulkundaje: The post mentions CASP as the poster child. CASP = Critical assessment of structure prediction. That's exactly what they….
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RT @slavov_n: Key factors that contributed to CASP success:. 1. Direct measurements of the prediction target.2. No significant unobserved f….
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RT @schwabpa: @simocristea The question one has to ask themselves is whether and under what conditions more eye balls on a topic translate….
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Just going to rebrand all my research to "Universal cancer cure". Oh its not a universal cancer cure you say? Why are you being so negative. you just cant understand the scope of my ambition and that im not afraid to fail.
If something is not a virtual cell, don't call it a virtual cell. A perturbation prediction model is not a virtual cell or an early incarnation of a virtual cell. It's not that difficult really. 3/.
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RT @anshulkundaje: Ah here is the new argument. Negative criticism of "virtual cells" is apparently stupid cuz nothing works the first time….
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RT @schwabpa: The proposed analogy between interpreting machine learning and biology really does not hold up at all. Understanding biology….
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