Circulation Research
@CircRes
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Circulation Research is an AHA journal focusing on basic science & translational cardiovascular research. https://t.co/DbXiggw5ZE https://t.co/ElAzkCBwac
Joined October 2009
5/5 Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia by Hong and Baudel et al @mf_navedo.
ahajournals.org
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein...
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4/5 Androgen Receptor Governs Tip Cell Formation in Cerebrovascular Malformations by Li et al
ahajournals.org
BACKGROUND: Cerebrovascular malformations are a pivotal cause of hemorrhage and neurological disability, orchestrated largely by aberrant vascular homeostasis. However, a malformed angiogenic...
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3/5 Lactylation of HADHA Promotes Sepsis-Induced Myocardial Depression by Zhang et al
ahajournals.org
BACKGROUND: Serum lactate levels are used to evaluate tissue hypoxia and predict outcomes in cases of sepsis and septic shock. Lactate can participate in a posttranslational modification known as...
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2/5 E3 Ubiquitin Ligase TRIM16-Mediated K63-linked Ubiquitination of DAB2 Enhances Integrin β1 Endocytosis to Facilitate Vascular Calcification by Lan et al
ahajournals.org
BACKGROUND: Vascular calcification is highly prevalent in patients with chronic kidney disease (CKD), and the underlying mechanisms remain elusive. Several studies have indicated an important role of...
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1/5 New @CircRes podcast #DiscoverCircRes chats with @abigail_ajanel @racampbell04 and @FrederikDenorme about their study Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation
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Hong et al found #Panx1 is a pivotal regulator of vascular function during diabetic #hyperglycemia. Learn about treating #diabetic #vascular complications at @miguelmab.bsky.social @mf_navedo @cpmm_pann_fun @jabdltaylor19 @eric_psilva
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Chen & colleagues show #GPR146 acts as a 'blood pressure sensor' driving vascular damage. Learn more about how blocking it could be a new #hypertension treatment at @Ling24581312
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Zeng & colleagues found the combination therapy of #genistein with #risdiplam reduced cellular stress & improved skeletal muscle phenotype in #SMA. Learn more at
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Check out the latest review in the Aug 15th issue of @CircRes by Dauvilliers & colleagues "Restless Legs Syndrome, Periodic Leg Movements, #Hypertension and #CVD " at
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Check out the latest review in the Aug 15th issue of @CircRes by Dr. T Huang "#Sleep Irregularity, #Circadian Disruption, and #Cardiometabolic Disease Risk" at
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Li & colleagues found that targeting the #androgen receptor may represent a potential therapy for #cerebrovascular malformations. Learn more at
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Check out the latest introduction to the review series in the Aug 15th issue of @CircRes "#Sleep and #CV Health" edited by Dr. S. Redline at
ahajournals.org
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Chen et al provide a new mouse model of coronary #atherosclerosis with spontaneous #MI. Learn more about the strong synergy of #hypercholesterolemia & #hypertension on #CAD at @alan_daugherty @TransCardio @honglu227
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Liu & colleagues discovered that #epigenetic dysregulation through #Dot1L-mediated #histone H3K79 dimethylation drove #Tbx6 expression in cardiomyocytes & promoted stress-induced #CardiacHypertrophy. Learn more at
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