Gregory Ducker
@gsducker
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Biochemist studying the intersection of cellular metabolism and disease. Assistant professor at the University of Utah @UUtah. Occasional skier
Salt Lake City, UT
Joined July 2009
🚨Postdoctoral position available now! 🚨We have an immediate fully funded position available in cardiac metabolism. We are looking for a highly motivated person to lead our animal model work in oxidative metabolism in heart! Pay is competitive with benefits offered. 1/2
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Excited to share my postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore our interactive web app: https://t.co/WLcglNT8xz
https://t.co/7KWcrmIx56
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Faeth Therapeutics' $92 Million Total Funding Powers PIKTOR Phase 2 Following 80% Response Rate in Endometrial Cancer 👀
businesswire.com
In the first paragraph and the About Faeth Therapeutics boilerplate of release issued Oct. 20, 2025, investor name should read B Group Capital (instead of B ...
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Our new work in @Cell_Metabolism by @ArtemAKhan describes three new SLC transporters, including SLC25A45, a mitochondrial transporter for methylated amino acids that is essential for carnitine synthesis and fasting adaptation. @RockefellerUniv
cell.com
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial...
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Excited to share our more recent preprint, on the role of tRNA modifications in stress granule assembly and melanoma metastasis! Congratulations to Riley Hughes and thank you to all the amazing co-authors and collaborators!
biorxiv.org
Metastasis is the leading cause of cancer related deaths, however therapies specifically targeting metastasis are lacking and remain a dire therapeutic need in the clinic. Metastasis is a highly...
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Fascinating new human genetics study from @StephenORahilly and others.... Also always good to remember that ketone signaling impairs lipolysis which has always sounded like fat trapping to me... Genetic impairment of ketone body signalling is a prevalent contributor to human
medrxiv.org
Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic...
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CRISPR came from yogurt bacteria. GLP-1s came from Gila monster venom. Taq polymerase came from hot spring bacteria. As much as we like to think that progress in biotech is driven by human design, our biggest breakthroughs over the years have all originated from nature.
The ocean is one of the last great frontiers of biology. More than 90% of all marine life (an estimated 2M species) have not been discovered. Also, only ~10% of the seafloor has been mapped at 100m resolution, "as compared to 100% of...Mars and Venus." We should sequence
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Lipids simplified! 🧱 Cholesterol – is the material needed for building cell walls, making hormones etc 🛻 Lipoproteins - are basically Trucks transporting Cholesterol along with other things through blood. Depending on size they are of many types. ⛽ Triglycerides – are
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🚨 Excited to share our new paper is out in Nature! 🔗 Reprogramming neuroblastoma by diet-enhanced polyamine depletion https://t.co/yftm24H0CJ
nature.com
Nature - Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle...
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The really galling thing about the Acetaminophen thing is that the observations of a potential link between its use in pregnancy and autism WERE taken seriously, and WERE studied using "gold standard science", and found not to be there. The same thing is true of the link to
jamanetwork.com
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.
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Congrats to my U of U collaborator Amandine Chaix on her awesome study about keto diet. TLDR: long term high fat diet probably bad. Heart people are right. Hypelipodemia has negative effects
A new study in mice uncovers some potential hidden costs to going keto. https://t.co/G6c03fBsF9
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Excited to share our new preprint—the main project of my postdoc in the Kaelin lab! Blocking HIF2 doesn’t just slow tumors—it can reverse cachexia and hypercalcemia in kidney cancer. In the OSRC-2 model, HIF2 inhibition restored weight, preserved fat/muscle, and rescued survival.
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An amazing opportunity for postdocs/ junior PIs. I attended one of these many years ago and it was transformative.
If selected, all expenses, except your own travel, will be covered by the Company of Biologists. We have an amazing line up of speakers working on aspects of metabolism from atoms to animals; please apply to join us!
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New work from our lab describing a role for mitochondrial glutathione in breast cancer metastasis @nicoledelgaudio @RockefellerUniv
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Reposting...applications open
For those of you hunting for your next position, please consider applying for a postdoctoral position in our lab. Our science is wild and exciting, and I promise to train and feed (yes, w/free food) you well. It doesn't hurt that we are on a publication hot streak.
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💡 Explain the Impact: Using data & AI to deliver a new cancer drug to clinic twice as fast as industry average Chase Neumann, PhD (@OncNTechStuff), Associate Director of Oncology, shares how we used the Recursion OS to discover new ways to target aggressive cancers and identify
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Huge congratulations to Xiling Shen @MDAndersonNews and @AyeletErez @WeizmannScience for their @CellCellPress paper: Vagal blockade of the brain-liver axis deters cancer-associated cachexia https://t.co/ITfwnEI8tR Clinical trials in patients with #PancreaticCancer forthcoming!
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I'm so honored to receive the 2025 Bruce Alberts Award for Excellence in Science Education. Thank you @ASCBiology and I look forward to this year's annual ASCB meeting in Philly!
Meet the 2025 ASCB Award Winners—trailblazing scientists honored for research, mentoring, education, and innovation. Celebrate excellence across all career stages in cell biology. Read more: https://t.co/d8fjwc4OIA
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Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide
nature.com
Nature Metabolism - John et al. show that upon classical activation, macrophages undergo nitric oxide-driven reprogramming of nucleotide metabolism, which affects immune functions and responses.
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Really important survey for Slc residents. Speak up and don’t let udot turn all of salt lake back into lethal traffic sewers
ACTION ALERT: UDOT needs to hear how much you support Salt Lake City's efforts to make its streets safer. The survey was apparently influenced by suburban car commuters. Since these streets are our streets, I urge you to take the survey right now. https://t.co/Fikodw6YKz
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What's the best creator marketplace you've used (to buy featured reels and tiktoks) and why?
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