Marcus Alexander, MD, PhD
@mqdicer
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Surgery Resident @UCSF_EastBay. Previously, neurosurgery @MiamiNeuroRes, scientist @Yale in @NAChristakis lab. PhD @Harvard, MPhil @UniofOxford.
San Francisco
Joined March 2016
Grateful to be part of this landmark study on human microbiome metagenomics that is out now in Nature.
"Gut microbiome strain-sharing within isolated village social networks" https://t.co/GWUvrPJUxa with @chocophlan, @JacksonPullman1, @mqdicer, @ShivkumarVs, @DrewPrinster, @adarshsingh110, RM Juárez, @eairoldi, @ilanabrito123 #HNL 2/
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Single prime editing system could potentially treat multiple genetic diseases
broadinstitute.org
Researchers have developed a genome-editing strategy that targets a common cause of roughly 30 percent of rare diseases and could vastly improve access to gene-editing treatments for patients.
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Using a single prime editor to rescue premature stop codons across many different diseases: a clever and promising way to dramatically scale prime editing therapies.
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature
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That @US_FDA is recognizing here the urgent need for regulatory strategies to evolve to match the pace of scientific advances in ways that streamline bringing the science safely to patients is incredibly important. I hope these new policies provide a foundation that will
Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The @US_FDA outlines a path to market entry for products where a randomized trial is not feasible. Learn more: https://t.co/kt9YyRP0Hg
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Please share: Post-doctoral position in the Human Nature Lab in the area of human social chemosignaling. What role do the odors we emit and our capacity for smell play in shaping social behavior? https://t.co/7ND78ktqkD
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I'm looking for a student researcher to join me at @GoogleDeepMind Montreal to work on getting the best generative AI into the hands of the best creative people. Your work will push models past their current frontiers and directly benefit creative engagements. Are you
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Yes, colleges face a crisis. It’s also an opportunity. Over two centuries, American higher education has periodically remade itself. Time to do it again. https://t.co/RO8MDt1Odf Prof. R. Howard Bloch and I have two modest suggestions. via @washingtonpost
washingtonpost.com
Over two centuries, American higher education has periodically remade itself. Time to do it again.
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In 1929, Alexander Fleming published his paper outlining the antibacterial properties of penicillin, and began the era of antibiotics. Read the Nobel Prize laureate's full article online: https://t.co/fPKDufTlbD
#OpenAccessWeek
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I’ll be starting a lab as an Assistant Professor @CornellEng @Cornell_CBE in 2026! We’ll combine synthetic biology and materials science to engineer microbes into living materials & therapies. Recruiting PhD students & postdocs - please get in touch! 🔗 https://t.co/XpDxeNzI0W
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On the cover of @TheJNS, @UCSF neurosurgeon Edward Chang, MD, PGY6 resident Anthony Lee, MD, PhD & their colleagues show that transposition approaches, especially with a pericranium sling, may result in more durable pain control for trigeminal neuralgia: https://t.co/SRRMVcJPzU
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Introducing Tahoe-x1 (Tx1) by @tahoe_ai. A 3-billion-parameter, single-cell foundation model that learns unified representations of genes, cells, and drugs, achieving state-of-the-art performance across cancer-relevant cell biology benchmarks, open-sourced on @huggingface. 🧵
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@JG_Underwood @aphillippy @acarroll_ATG @pushmeet @GoogleDeepMind @GoogleResearch @kishwarshafin update: Google DeepMind edited the blog entry and now it gives appropriate credit - much better!
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Outstanding episode with the brilliant scholar, @VirusesImmunity. We talk about Covid, long COVID, vaccines, Alpha Gal syndrome, and her upcoming receipt of Keio scientific award! @hmkyale reviews divisive climate around healthcare. I talk H5N1.
insights.som.yale.edu
Howie and Harlan are joined by Yale School of Medicine immunologist Akiko Iwasaki, a leading authority on vaccines and long COVID. Harlan reflects on America's crisis of trust in federal agencies;...
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Pleased to share that the Kennedy School has been authorized to conduct a faculty search in American politics This is as an extraordinary opportunity for us - please share widely with your networks and consider applying! This is a tenured position at the rank of full professor
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Cells don’t just exist — they talk, signal, and collaborate. Our work GraphComm is now out in @SciReports ! With GraphComm, we’re teaching AI to listen in on this cellular conversation — a step closer to building the virtual cell. 🧬🤖 🧬 GraphComm is a graph-based deep
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What a disaster for U.S. science. We are losing the future–and no one benefits from this, really no one. Humankind loses when we stop doing science.
an absolute shame. @harvard cutting PhD admissions "The Organismic and Evolutionary Biology department will shrink its class size by roughly 75 percent to three new Ph.D. students [...] Molecular and Cellular Biology will reduce its figure to four new students, and Chemistry and
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When we worked on the Cell to Sentence paper two years ago, it was hard to imagine this result. Back then, we were only training tiny models like the ones you fine here https://t.co/hZ2DrXLsDO By scaling the model to 27b parameters and more data, the same method generated a
An exciting milestone for AI in science: Our C2S-Scale 27B foundation model, built with @Yale and based on Gemma, generated a novel hypothesis about cancer cellular behavior, which scientists experimentally validated in living cells. With more preclinical and clinical tests,
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The model + resources are now on HuggingFace and GitHub so researchers can keep building and experimenting. More details here: https://t.co/NSGcfBL9We
blog.google
We’re launching a new 27 billion parameter foundation model for single-cell analysis built on the Gemma family of open models.
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