I know so many of my fellow
#LongCOVID
sufferers are awaiting a treatment.
I want you to know it’s a very difficult disease to figure out - it’s clearly a bit of a mystery.
I want you to know that my team at
@MaxwellBiosci
is working on it.
🧵 on our work
I can no longer track the number of highly concerning
#COVID
#variants
SARS-CoV-2 is completely out of control.
The virus is accelerating evolution towards combinations (a multitude) of the most dangerous, AND highly virulent.
All past pharmaceutical tools border on obsolete.
What I look like on an airplane. I wear a silver infused gator over the top of a N95 😷 to help with filtration (silver binds viruses) & the gator is less intimidating for those who don’t like 😷
Headed to Florida for an investor conference to raise money for
#longCOVID
. Raised…
🚨Breaking News: new virus in Argentina. Appears flu-like. Likely not
#COVID
. Highly lethal. Now 10th case in different location. Spreading.
- 10 cases
- 3 deaths
- 2 patients infected 8 medical workers
- 6 on ventilators
⚠️UNKNOWN PNEUMONIA—Very worrisome—3 people have died, 9 people infected, of which 8 medical workers, are in hospital after developing a “pneumonia of unknown origin”—Argentinian authorities announced. Not COVID or flu.
#ArgentinaPneumonia
By
@sneweyy
⚠️
#monkeypox
is here to stay. It is uncontained and doubling in size each week. That means at least 1,000,000 cases by November.
In case it matters - it is spreading via contact as well as airborne - not just sexually transmitted. Excellent thread…
NEW—It is time for the global public health community to recognize a growing reality:
#Monkeypox
is now a pandemic—unless we declare an emergency & act quickly to combat it, we risk repeating the same mistakes we made with covid.🧵
@kavitapmd
@yaneerbaryam
@elonmusk
@micsolana
I’m not a fan of the action. However, the first amendment applies to government suppression of free speech - not private (political party) suppression of speech.
This is wrong and horrible. Not technical first amendment stuff though.
12. This is a world-first scientific breakthrough, mostly been overlooked by popular media.
A drug candidate that kills herpes, all tested corona viruses, all tested influenza, all pathogenic bacteria, fungus, mold, yeast and biofilms - AND is safe in animal tests.
Notable?
This
#monkeypox
case report - PCP said “What is MonkeyPox?” Referred her to dermatologist.
Dermatologist refused to see her, referred her to CDC.
CDC said “see your PCP.”
100,000 cases predicted in Aug
1,000,000 cases in Nov
6) we are so unprepared for
#monkeypox
that it’s not even funny. Listen to one woman trying to get testing (from 2 weeks ago). It’s a complex nightmare.
1. What causes
#LongCOVID
?
Our theory: Chronic COVID is a Post Viral Syndrome (PVS), in which the immune system is weakened by the trigger virus and many other opportunistic pathogens are allowed get a chronic foothold.
2. I had post viral syndrome after an extremely debilitating bout with West Nile Virus. Chronic fatigue syndrome, depression, memory loss, weakened immune system and motor dysfunction. Took me a while to walk and even type on a keyboard. Years to complete recovery.
16 Our FDA docs are finalized and we’re submitting them for our first “Pre-IND” meeting with the FDA this month.
Read more about our tech, science and plan to treat
#LongCOVId
here:
🙏🏼 Pray that we are successful. I believe it’s the world’s best hope.
3. Now I have
#LongCOVID
. Interesting that I got post viral syndrome after both major viral events.
Back to the causes and how we are developing a single drug to treat post viral syndrome and Long COVID…
⚠️
#Ebola
has got nothing on
#COVID
2023. Seriously - we’re about to see layered winter waves of COVID immune resistant strains in the Northern hemisphere that will be devastating. That is a fact.
Ebola is a distraction - only spreads after debilitating symptoms. Easy vaccine.
4. Cause
Once the virus weakens the immune system a polymicrobial invasion occurs. Bacteria and fungus invade and setup biofilms walls around their polymicrobial ecosystems that block the immune system.
Wastewater from Brooklyn, NY show
#SARSCoV2
virus levels have reached 50% levels of last winter’s initial Omicron crisis. Hospitalizations are rising too. Not good.
#COVID19
#CovidIsNotOver
Breakthrough long COVID therapy involving Bifidobacterium synbiotic reported in The Lancet Infectious Disease confirming theory
@MaxwellBiosci
and
@chydorina
have been working in separately, that
#longcovid
is a polymicrobial dysbiosis.
The breakthrough study conducted in Hong…
11. We found a way to mimic LL-37 in the form of a small molecule - not a peptide.
We attached the functional portions that make LL-37 work to a stable chemical backbone.
We published stable efficacy against SARS-CoV-2, Herpes, bacteria, etc
5. The biofilm theory of
#LongCOVID
and Post Viral Syndrome is by far the most evidenced and backed by science.
I’ll post a few good articles, including COVID but also others. This one is RSV - which is going around right now especially in children.
7. Its a Pathogen Party, and Everyone’s invited
It’s not just bacteria and fungus, it’s also other viruses especially the herpes family: HSV-1 & 2, and the Human Herpes Virus family (many) because it is so common (over 80% of population).
.
9. The Human Immune System
Your immune cells use a single peptide - Human Cathelicidin Antimicrobial Peptide (aka “LL-37) to tackle all of those bugs.
What if we could make a drug to mimic that peptide?
8. PROBLEM, **very difficult**
So, it’s lots of pathogens and it’s a different mix of bugs for each patient. In order to best it we need a drug that stops enveloped viruses, pathogenic bacteria, fungus, mold, yeast AND biofilms.
We have a potential solution…
CDC should sound the alarm!
9 June: 45 ☑️
16 June: 90 ☑️ (85)
23 June: 180
30 June: 360
This highly morbid
#MonkeyPox
weekly case-doubling trend appears to continuing at very close to an exact doubling. Looks like it’s slightly less than a full double each week so far.
⚠️ Pandemic Alert -
#MonkeyPox
is a rapidly evolving pandemic threat. I agree with
@DrEricDing
and epidemiologists.
Why are the CDC & WHO dragging their feet? Declaration of pandemic frees up funds to fight bio threats.
Also, wear masks. MonkeyPox is airborne droplets. 💦😷
NEW—It is time for the global public health community to recognize a growing reality:
#Monkeypox
is now a pandemic—unless we declare an emergency & act quickly to combat it, we risk repeating the same mistakes we made with covid.🧵
@kavitapmd
@yaneerbaryam
We’re headed into a record breaking
#COVID
-19 wave. Add the heat wave in Texas and the Southwest driving everyone to breath the same air indoors and we’re looking at a perfect storm for viral spread in Texas for this COVID wave.
⚠️My god —
#COVID19
hospitalizations up ⬆️ 33% in just 1 week in England 🏴!📌Plus COVID deaths rose ⬆️ 8% in a week too!
#BA5
and
#BA4
are surging like mad in England - not even dominant yet - and it’s already bad. 📌Hospitalizations in young kids up 30% too!
#CovidIsNotOver
🧵
6. The pathology of biofilm enabled SARS-CoV-2 Post Viral Syndrome in
#LongCOVID
is well studied in bats. The biofilm allow for the virus to evade the immune system, continue to evolve and fuels the growth of pathogenic fungus and bacteria.
10. Human Cathelicidin Antimicrobial Peptide “LL-37”
LL-37 is a possible “super drug” because it kills all the bad bugs. The problem is nobody has been able to find a way to stabilize it. Bacteria create anti-LL-37 enzymes that eat LL-37. It’s a battle.
13. The drug candidate is highly potent while remaining safe in animals and in preclinical human lung tissue. Tested in mice, rats, and Fauci’s team at NIH NAIAD tested in Syrian hamsters for us.
14. Here’s how your immune system peptide “LL-37” works (and how our potential drug works).
It targets a type of fat that only shows up in diseased or infected cells, and pathogens. This is how your immune system knows when to use it. Same with our molecule.
15. The University of Texas Medical Branch confirmed our study on our “CLAROMER” brand molecule using an electron microscope in their bio containment level 3 (BSL-3) lab. You can see it disintegrates the viral envelope.
🚨
#monkeypox
is extremely transmissible on surfaces. It does not *require* rubbing against an open ulcer.
Recommend all public bathrooms be sanitized with bleach multiple times per day.
I salute the teams working to develop therapeutics for this disease.
⚠️Geeeeezzz—2 healthcare workers who wore full PPE (N95, gloves, gown, goggles) got
#monkeypox
in 🇧🇷 after visiting monkeypox patient. Despite **washing hands**, the 2 female HCWs both positive days later. ➡️They didn’t sanitize the clipboard & sample box!
MonkeyPox is displaying a greater rate of infection and growth than ever seen before, for this virus. We desperately need a prophylactic or therapeutic for this disease. Maxwell is working on this as fast as we can.
📍50% Attack Rate—
#Monkeypox
has been shown to have a household attack rate (% persons living with an infected person that develop symptoms of monkeypox) of **50%** in a real-world outbreak, not just theory. Contrast—COVID’s household attack rates ~10-20%.
⚠️ This is essentially unavoidable. It’s a matter of when vs “if.”
The reported numbers will be *much lower* than this due to lack of testing. Reported numbers likely 1M by November. 🙈🙉🙊
#monkeypox
Is
#monkeypox
an emergency yet?—“Monkeypox is mutating up to 12X faster than expected, amid warnings 🇬🇧 could see as many as 60,000 new cases a day” by 2022 end.
I think our projection (HT
@JPWeiland
) of 100k cases by August & 1 mil by Sept is realistic.
🚨Agree! Expect a big surge in cases once college dorms open up to the new students.
Multiple cases reported in prison systems already. Health officials are expressing more concern about prisons and dorms.
Must read—this encapsulates much of my frustration-“N America barrels toward fall—when students cluster in classrooms, families mingle indoors, respiratory viruses go hog wild—monkeypox outbreak balloons, & HC system remains strained.”
HT
@KatherineJWu
🙏
What
#LongCovid
#MECFS
feels like:
Being something formerly human that has painfully died, resurrected, then slain again, dried out, stretched out full length and tied down to a bed with an occasional disbelieving audience to observe and comment upon its suffering.
@paulg
“War is hell.” I think that is the quote.
It is especially bad when the enemy won’t dress in a uniform, actively hides behind civilians, and holds them hostage on the military targets it *knows* will be targeted so that clips like this will be shared by sensitive folks like us.
@maosbot
I regularly sleep in a mask for these reasons:
1) keeps me from dehydrating too badly
2) keeps my mouth from hanging open
3) I sleep on planes almost as often as in a hotel and almost never at home
4) air plane air is absolutely filthy
Failing to code
#monkeypox
may be resulting in a massive undercount of cases because of the amount of work involved to report it to
@CDCgov
.
It’s anyones guess what the real numbers are at this point.
@CDCDirector
please help!
📍What the heck is wrong the
@CDCgov
? ➡️CDC still has not coded monkeypox in its disease reporting system—it’s been months
@CDCDirector
!
This means local officials must:
📌 manually data enter 📊 case reports.
📌manual fax testing 🧪 requests to labs!
When?
We’re kicking around logistics and financing right now to try to fit in
#LongCOVID
FDA phase 1b human trials in Dec 2024.
Very rough date and almost certain to move around a bit.
People ask why I wear a mask in enclosed areas.
1)
#COVID
is just as serious as it ever has been. Immune, vax, antibody resistant.
#LongCOVID
is a horror.
2) N95 is optimal blend of function, and convenience. Any mask works better than no mask - it’s about air flow resistance.
I love this video from RIKEN in Japan.
It models the flow of exhaled air in various different settings under different conditions.
As well as the flow patterns being very beautiful, it also highlights the importance of good quality masks (FFP2/FFP3)
🚨
#MonkeyPox
is already showing up in college dorms. This likely results in a gain in spread not slowing. The virus is likely spreading much faster than testing can keep up.
If you have kids in college, consider asking them to self quarantine. Surface contact spread possible.
"If the virus spreads to other populations, such as college dorms — where cases have already been reported — the testing bottleneck could ultimately make it impossible to contain the spread."
$GOVX $SIGA
@OnlyEnnui
@MaxwellBiosci
Our tests in Syrian hamsters shows total relief of
#MEcfs
, return to normal activity and appetite. Say a prayer that it works. I pray every day that this will heal me and the world.
@tferriss
Do not indulge in dreams of having what you have not, but reckon up the chief of the blessings you do possess, and then thankfully remember how you would crave for them if they were not yours. - Marcus Aurelius
19. FDA Pre-IND Meeting
The FDA response received March 17th was encouraging. They told us what they need from us for the Investigational New Drug Application, and it’s all achievable and what we were planning for.
So, we’re moving forward nicely.
Last year, I had a conversation that changed my life.
It caused me to upend everything and move across the country.
The lesson from it may change yours:
@Ecliptic_09
@Dakota_150
@MaxwellBiosci
I am use supplements, probiotics, yeast cleanse, no sugar, no alcohol, no gluten, no dairy, anti-inflammatory diet, fish oil, turmeric, ginger, ceremonial matcha green tea,high fiber, 5 step RO filtered water, and air purifiers in the house. My chronic symptoms are under control.
🚨Smallpox spreads identically to
#monkeypox
. This virus is not an STD. It is a pandemic, mostly contact spread, also airborne via saliva droplets. 3-6% fatality rate.
Shaking hands is no longer a good idea. 🙏🏼
Wear a mask.
⚠️Exponential surge to almost 13,000
#monkeypox
cases globally—with no signs of slowing—on track to hit 100,000 in August 👀(per earlier forecast). The next
@WHO
meeting to discuss making a public health emergency declaration is… in 4 days on July 21. Pandemic yet? Heck yeah. 🧵
People ask me how I recovered from
#longCOVID
and here’s part of it. I ate nothing but meat, these spices, olive oil, apple cider vinegar and cruciferous vegetables for over a year.
@drgurner
I haven’t written it, but I’d be happy to talk about it on a podcast or with a group of folks on a Spaces chat.
Maybe get a group of people who have significantly recovered to talk about how they did it in detail.
@waitbutwhy
Tim Urban.
Q: Why do the powerful generally prefer the unpleasant discomfort of status quo over the foreign but otherwise much improved best outcome for everyone, including themselves? Rephrased, why does power corrupt humans?
@venus_iscariot
@mombojom
@historyinmemes
Sumer as cradle of civilization is also highly ethnocentric to European civilization. Much if the language and religion of western civilization come from the Sumerian civilization. So, antediluvian and Asian civilizations are not as well received by current archeological dogma.
Not only is it real but the third leading neurological disorder
#longCOVID
is not being rapidly educated to US and Western GPs and hospitals.
This needs to change.
“Long Covid occurs in about a third of Covid survivors and is now the third leading neurologic disorder in the United States.”
New Northwestern study reveals alarming impact of long Covid on patients
@jonsopel
@charlesarthur
We don’t know what mRNA vaccines do. They haven’t been tested.
Show me a study that says they don’t result in cancer.
There isn’t one. We are the test group.
The COVID vaccines were expedited by the FDA due to national emergency. New mechanism of action vaccines are usually…
@ShaneAParrish
Or they’ll learn to write by chatting with
#chatGPT
. I can see how chatGPT could be adapted to become an incredibly adaptive personalized learning platform.
@garrytan
He is literally quoting Bob Metcalfe, founder of 3COM. Jobs was excellent at taking others ideas and marketing the hell out of them. Xerox PARC was just one example.
I know so many of my fellow
#LongCOVID
sufferers are awaiting a treatment.
I want you to know it’s a very difficult disease to figure out - it’s clearly a bit of a mystery.
I want you to know that my team at
@MaxwellBiosci
is working on it.
🧵 on our work
@erinbiba
@charlesarthur
So don’t take vitamin C, don’t get exercise, don’t eat good food, saunas don’t matter… because the immune system can’t be boosted?
That’s nuts. There are thousands of studies on vitamin D, cathelicidin innate immune up regulation and more ways to boost the immune system.
@historyinmemes
Upon arriving in San Francisco, Governor Newsom had her arrested for interfering with labor union activities, gave her $1000 to the first mate who spent it on Tranq, and her husband died in a mugging on his way to the hospital.
Coronavirus variant BF.7 is the new variant of concern outpacing others. Emergence of new
#COVID
variants “is continuing evidence herd immunity is not possible. SARS-CoV-2 rapid mutation will continue to avoid both natural and vaccine immunity. Each time is a risk for
#LongCOVID
@smithsj
@ClairElle__4
…and I am an example of a severe case of post viral syndrome (west Nile virus) who got better. It took me years, but I’m thriving. I had to learn to walk again, how to think, changed my personality, it’s a new me not a return to the old me.
@elonmusk
@paulg
Absolutely nonfactual. I have the proteomics data to prove it. Biological aging clocks also prove it. A lot is in the genes, but there’s a LOT you can do to manipulate your health span.
Happy to discuss.
⚠️ Massive spike in COVID cases in India, up 500+% with similar dramatic spikes in several other countries. We may be headed back into extreme case counts. Pandemic is not over.
#COVID
#pandemic
#longCOVID
#india
@therustychemist
@MaxwellBiosci
Yes. Our tests show excellent access to the brain and CSF via nasal spray, which is the method of delivery we are submitting to FDA. Animal tests shows very well tolerated in neurons.
@Andy91035018
@joannagtweets
@almurray
The conductor is generally perceived as the most generally talented musician, leader, hardest worker, best ear, etc. the selection process from within the orchestra is incredibly competitive. What does a clothing designer do, if they are not the textile?
@welcomewords
@MaxwellBiosci
👍🏻💯
Not so long for me, about 18 years since I got West Nile. I agree this has been mostly ignored by pharma drug development. A drug that can kill virus, bacteria, fungus and biofilm all at once has been thought to be impossible. Many pharma still doubt our confirmed studies.
@isadwatson
@vkhosla
You didn’t capitalize the first letter of any of the sentences in your response.
You misspelled “come on.”
You should use a comma around a name or title if it is being used as nonessential details within the sentence and therefore must be capitalized as well.
Good logic.
C-
@drgurner
@MaxwellBiosci
@chydorina
Couldn’t agree more. I just gave a talk about using probiotics for cognitive impairment in Miami. VSL
#3
is the refrigerated probiotic I use. Extremely high levels of bifodo and a large diversity of other beneficial microbes.
Just re-re-re-read Old Man’s War by
@scalzi
- his “SmartBlood” inspired me to wrangle the world’s top bioengineers to engineer human blood. MaxWell Biosciences was the result.
@Derek_a_Franks
It’s in the discourse. People just have incredible pandemic fatigue. I run an antiviral biotech and I can’t even pitch investors on COVID therapeutics. Nobody wants to hear the C word.
One of our drug candidates, MXB-27,369, that is similar to the one we are developing for
#LongCOVID
was just shown by the NIH Rocky Mountain Lab to be highly effective against Ebola. There are no cures for Ebola - yet.
Happy Thanksgiving!
Making pomegranate for the family dinner and thinking about
#MECFS
and how wonderful pomegranate is for it.
Pomegranates are not just delicious, they're also great for your gut health, thanks to the teamwork between the fruit and your gut microbiome!
When…
@kirstler31
I got better after severe MECFS. 2 weeks of coma. It took me about 6 months to be mostly functional and able to drive again. I had to change my diet completely (carnivore, grass fed free range, lots of fat and protein). No sugar, no dairy, no gluten. 7 stage reverse osmosis…
@RobertMSterling
CEO C: We’re an AI company. AI is everything now. We’re changing the company URL to . I’m sending a cold intro pitch deck to
@vkhosla
tomorrow.
@tessfalor
Unfortunately this comes with the role of Healer. Burned-at-the-stake and crucifixion are a couple of the outcomes of good Healer intent.
Think of the nurses and docs during COVID who now have insurance-benefit-denied
#longCOVID
because of nearly constant exposure.
The…
Maxwell Biosciences is developing the “One Drug for Many Bugs” CLAROMER™ biotechnology - preclinically active against all tested variants of SARS-CoV-2 and Influenza. A NIAID-funded Syrian Hamster study showed full protection against the symptoms of
#COVID
& possibly
#LongCOVID
.
Without
#longCOVID
there certainly would be a chance for
#MyalgicEncephalomyelitis
to be trending right now.
Before long COVID I had years of MECFS from West Nile Virus. I lost my job, and much of my savings.
However it caused me to become a biohacker and researcher…
@OnlyEnnui
@MaxwellBiosci
Same here. Family has a connective tissue disorder which makes us more stretchy and bendy. Also makes us more senstive to viruses for some reason.
Just looked this up: Cyanide gas poisoning may also cause respiratory symptoms of bronchitis, pneumonia, lung oedema and pneumonia, and digestive symptoms of vomiting and stomach pain.