Amy Proal, PhD
@microbeminded2
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Microbiologist at @polybioRF: studying how persistent pathogens drive inflammaging, mitochondrial dysfunction & cognitive decline #longcovid #lyme #alzheimers
Joined September 2017
It was great to do this podcast. Persistent #viruses - and many bacteria, fungi and even parasite pathogens - directly hijack our #mitochondria. They can hack and distort human gene signaling that controls senescence & inflammaging. This knowledge is huge for longevity treatments
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From Crisis to Cure: PolyBio is supporting top HIV researchers to pivot into the study and treatment of Long COVID. Watch the full video to learn how this collaboration is being maximized & driving forward innovative research: https://t.co/Fc6rLyNsab
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Spritz Vibe. Limited Edition. Frosted over & fresh for the season, Spritz Vibe Sparkling Snowball Frost Limited Edition is here! CELSIUS. LIVE. FIT. GO.
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It's still a mystery why some people with plaque have heart attacks while others don't. But a new study found viridans streptococci (oral bacteria) formed biofilms in the plaque of 42% of sudden death victims. Chronic bacterial infection may contribute to heart attacks.
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Get ready—PolyBio’s Fall 2025 Symposium is coming up! On Friday November 14 from 11-5 PM EST, join us for exciting project updates on PolyBio-supported #LongCovid & related chronic illness research. Register now: https://t.co/wjM2g9GZ0m
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8/ In the meantime at PolyBio we're support projects to advance diagnostics for Babesia, so that detection of the parasite in patients with infection-associated chronic illness can be most accurate:
polybio.org
Project Summary: To develop novel enrichment culture, serological, and visualization methods for the diagnosis of the parasite Babesia in people with...
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7/ Overall if you are a patient with an ME/CFS diagnosis it's worth getting tested for Babesia. Testing isn't perfect but IgeneX Babesia FISH test is a good start:
igenex.com
Learn about the Babesia FISH test and the specifics of what it is testing for. Explains the principle, advantages, and test interpretations.
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6/ If a person has red blood cells infected with Babesia such oxygen extraction might be less efficient
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5. Indeed, during exercise, red blood cells increase their oxygen extraction from tissues by as much as 70-80% to meet heightened metabolic demands
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4/ It's possible that exercise - which could potentially exacerbate issues with oxygen extraction - could lead to even further sharp drops in haptoglobin
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3/ In Babesia infection, the rapid release of hemoglobin overwhelms the body's ability to produce enough haptoglobin, leading to a low levels of the protein
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2/ Specifically, Babesia parasites invade and multiply within red blood cells, causing them to rupture. When red blood cells rupture, free hemoglobin is released into the bloodstream. Haptoglobin is a protein that binds to free hemoglobin to prevent it from damaging the kidneys
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1. Worth noting that low haptoglobin is commonly associated with Babesia infection. Babesia is a parasite that in a chronic capacity can drive fatigue, body aches, headaches and other symptoms often experienced by patients with an ME/CFS diagnosis
pmc.ncbi.nlm.nih.gov
Babesiosis, a zoonotic parasitic infection transmitted by the Ixodes tick, has become an emerging health problem in humans that is attracting attention worldwide. Most cases of human babesiosis are...
New study on PEM! After a mild stress challenge, people with ME had a sharp drop in haptoglobin (Hp), a blood protein that protects the body from damage when red blood cells break down. Low Hp correlated with worse PEM & cognition. https://t.co/wLeZfzr4dE 1/ #LongCovid #pwme
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Yes! I’m excited to speak at the workshop. I will emphasize that a translational trial testing if a broad spectrum monoclonal can decrease circulating spike protein is a huge priority for the #LongCOVID space.
We are very excited for the coming RECOVER-TLC workshop at which SPEAR representatives Drs. David Putrino @putrinolab and Amy Proal @microbeminded2 will discuss our proposal for Long Covid antibody trialing! https://t.co/fRZN6DXW7U
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@polybioRF 11/ I'll be giving a @TEDx talk on infectious contributions to aging, and solutions to combat such age distortion this October in Boston. For now, check out this podcast where I go into more detail on the topic:
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@polybioRF 10/ For example, this study found that people who routinely took over the counter anti-herpesvirus drugs were 10X less likely to develop Alzheimer’s disease later in life:
pubmed.ncbi.nlm.nih.gov
This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using...
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@polybioRF 9/ And some of the therapeutic strategies capable of mitigating infectious contributions to aging are such low hanging fruit to implement
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@polybioRF 8/ Simply put: no one will succeed in extending healthspan/lifespan if they have a virus or parasite in their brain seeding Alzheimer’s plaque or distorting the epigenetic environment
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@polybioRF 7/ Overall we must incorporate infection into aging to models to accurately characterize drivers of #senescence and to optimize therapeutic strategies that target both host and microbial contributors to aging
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6/ We are creating a @polybioRF program specifically focused on developing such diagnostics, which will innovate the longevity space. Message me if you want to learn more.
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5/ The lack of #diagnostics capable of detecting pathogen activity across a lifetime remains a major bottleneck. Emerging tools—such as ultrasensitive protein assays and antigen immune biosensor platforms—can enable integration of pathogen detection into biological age tracking.
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