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Amy Proal, PhD Profile
Amy Proal, PhD

@microbeminded2

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Microbiologist at @polybioRF: studying how persistent pathogens drive inflammaging, mitochondrial dysfunction & cognitive decline #longcovid #lyme #alzheimers

Joined September 2017
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@microbeminded2
Amy Proal, PhD
11 months
It was great to do this podcast. Persistent #viruses - and many bacteria, fungi and even parasite pathogens - directly hijack our #mitochondria. They can hack and distort human gene signaling that controls senescence & inflammaging. This knowledge is huge for longevity treatments
@mike_lustgarten
Mike Lustgarten, PhD
11 months
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@polybioRF
PolyBio
11 days
From Crisis to Cure: PolyBio is supporting top HIV researchers to pivot into the study and treatment of Long COVID. Watch the full video to learn how this collaboration is being maximized & driving forward innovative research: https://t.co/Fc6rLyNsab
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@CelsiusOfficial
CELSIUS Energy Drink
2 months
Spritz Vibe. Limited Edition. Frosted over & fresh for the season, Spritz Vibe Sparkling Snowball Frost Limited Edition is here! CELSIUS. LIVE. FIT. GO.
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@BrandonLuuMD
Brandon Luu, MD
22 days
It's still a mystery why some people with plaque have heart attacks while others don't. But a new study found viridans streptococci (oral bacteria) formed biofilms in the plaque of 42% of sudden death victims. Chronic bacterial infection may contribute to heart attacks.
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@polybioRF
PolyBio
1 month
Get ready—PolyBio’s Fall 2025 Symposium is coming up! On Friday November 14 from 11-5 PM EST, join us for exciting project updates on PolyBio-supported #LongCovid & related chronic illness research. Register now: https://t.co/wjM2g9GZ0m
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@microbeminded2
Amy Proal, PhD
2 months
8/ In the meantime at PolyBio we're support projects to advance diagnostics for Babesia, so that detection of the parasite in patients with infection-associated chronic illness can be most accurate:
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polybio.org
Project Summary: To develop novel enrichment culture, serological, and visualization methods for the diagnosis of the parasite Babesia in people with...
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@microbeminded2
Amy Proal, PhD
2 months
7/ Overall if you are a patient with an ME/CFS diagnosis it's worth getting tested for Babesia. Testing isn't perfect but IgeneX Babesia FISH test is a good start:
igenex.com
Learn about the Babesia FISH test and the specifics of what it is testing for. Explains the principle, advantages, and test interpretations.
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@microbeminded2
Amy Proal, PhD
2 months
6/ If a person has red blood cells infected with Babesia such oxygen extraction might be less efficient
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@microbeminded2
Amy Proal, PhD
2 months
5. Indeed, during exercise, red blood cells increase their oxygen extraction from tissues by as much as 70-80% to meet heightened metabolic demands
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@microbeminded2
Amy Proal, PhD
2 months
4/ It's possible that exercise - which could potentially exacerbate issues with oxygen extraction - could lead to even further sharp drops in haptoglobin
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@microbeminded2
Amy Proal, PhD
2 months
3/ In Babesia infection, the rapid release of hemoglobin overwhelms the body's ability to produce enough haptoglobin, leading to a low levels of the protein
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@microbeminded2
Amy Proal, PhD
2 months
2/ Specifically, Babesia parasites invade and multiply within red blood cells, causing them to rupture. When red blood cells rupture, free hemoglobin is released into the bloodstream. Haptoglobin is a protein that binds to free hemoglobin to prevent it from damaging the kidneys
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@microbeminded2
Amy Proal, PhD
2 months
1. Worth noting that low haptoglobin is commonly associated with Babesia infection. Babesia is a parasite that in a chronic capacity can drive fatigue, body aches, headaches and other symptoms often experienced by patients with an ME/CFS diagnosis
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pmc.ncbi.nlm.nih.gov
Babesiosis, a zoonotic parasitic infection transmitted by the Ixodes tick, has become an emerging health problem in humans that is attracting attention worldwide. Most cases of human babesiosis are...
@ahandvanish
Hannah Davis
2 months
New study on PEM! After a mild stress challenge, people with ME had a sharp drop in haptoglobin (Hp), a blood protein that protects the body from damage when red blood cells break down. Low Hp correlated with worse PEM & cognition. https://t.co/wLeZfzr4dE 1/ #LongCovid #pwme
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@microbeminded2
Amy Proal, PhD
2 months
Yes! I’m excited to speak at the workshop. I will emphasize that a translational trial testing if a broad spectrum monoclonal can decrease circulating spike protein is a huge priority for the #LongCOVID space.
@Invivyd
Invivyd
2 months
We are very excited for the coming RECOVER-TLC workshop at which SPEAR representatives Drs. David Putrino @putrinolab and Amy Proal @microbeminded2 will discuss our proposal for Long Covid antibody trialing! https://t.co/fRZN6DXW7U
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@microbeminded2
Amy Proal, PhD
3 months
@polybioRF 11/ I'll be giving a @TEDx talk on infectious contributions to aging, and solutions to combat such age distortion this October in Boston. For now, check out this podcast where I go into more detail on the topic:
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@microbeminded2
Amy Proal, PhD
3 months
@polybioRF 10/ For example, this study found that people who routinely took over the counter anti-herpesvirus drugs were 10X less likely to develop Alzheimer’s disease later in life:
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pubmed.ncbi.nlm.nih.gov
This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using...
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@microbeminded2
Amy Proal, PhD
3 months
@polybioRF 9/ And some of the therapeutic strategies capable of mitigating infectious contributions to aging are such low hanging fruit to implement
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@microbeminded2
Amy Proal, PhD
3 months
@polybioRF 8/ Simply put: no one will succeed in extending healthspan/lifespan if they have a virus or parasite in their brain seeding Alzheimer’s plaque or distorting the epigenetic environment
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@microbeminded2
Amy Proal, PhD
3 months
@polybioRF 7/ Overall we must incorporate infection into aging to models to accurately characterize drivers of #senescence and to optimize therapeutic strategies that target both host and microbial contributors to aging
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@microbeminded2
Amy Proal, PhD
3 months
6/ We are creating a @polybioRF program specifically focused on developing such diagnostics, which will innovate the longevity space. Message me if you want to learn more.
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@microbeminded2
Amy Proal, PhD
3 months
5/ The lack of #diagnostics capable of detecting pathogen activity across a lifetime remains a major bottleneck. Emerging tools—such as ultrasensitive protein assays and antigen immune biosensor platforms—can enable integration of pathogen detection into biological age tracking.
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