kim: emulsified and digested by SARS-CoV-2
@therustychemist
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Free speech, separation of church and state, no unreasonable search and seizure, ethics clauses for the Supreme Court, no Citizens United, equal pay. #WeNotMe
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Husband had a conference in Las Vegas last week. Wore Aura 3M the whole time. Yesterday, everyone in the conference call was sick except him. CEO, also sick, pointed out on the call that he must be doing something right because he was the only one masked and the only one not sick
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So strange that in the 18 yr followup study of SARS survivors, the most common symptom was osteoporosis and necrosis of the femoral head. Isn’t that similar to HIV?
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I just spent $4600 on lab tests to prove drs are allowing us to die. It will cost $13,800 to test the other three adults. I cannot get these tests for my 16yo. That is crushing. I have to hope her drs will do the right thing once they see my and the older girl’s results. 🤞
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I wear an N95 mask or better because SARS-CoV-2 is airborne and it is not a cold or the flu. It is definitely not mild. It means it’s hiding from your immune system.
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@NoHealthNoFun
I think it was pointed out for a reason as he got a little flack for wearing a mask from some colleagues.
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SARS-CoV-2 is not the disease of boomers that we’ve been led to believe it is. It is far more damaging on the middle aged and children.
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I ran some Binax antigen tests today. Kind of interesting. Antigens are being shed in fecal matter. Why are we testing noses and throats?
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Both virus and spike protein in urine of patients with acute kidney injury. Spike causes syncytia in HEK293-ACE2+ and VEROE6 cells.
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@DrJohnHhess
Me! As in has happened to me personally. You also walk into and out of a room maybe 3x before you remember why you went in the first place. I am fortunate it has receded mostly. But was likely just exposed again and it came roaring back for a few days. It’s not pleasant.
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@alexmeshkin
It’s almost like media messaging wedged us perfectly into two groups…like an experimental and control, no?
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@LauraMiers
There is not enough space to list. Give me a few minutes to finish something and I’ll get specifics. Most are heart, liver, kidney, lipids, lymphocytes, some viral.
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Someone needs to inform Harvard that I have a child that lost 50% of her IQ after mild infection. Oops…I’m sure we’re supposed to keep that quiet. Might mean a SARS-CoV-2 infection is dangerous to kids/adolescents.
There’s literally dozens of papers documenting this. (Google “Covid” and “cognitive damage”).
Cognitive damage after Covid can happen to anyone, and is equivalent to about ten points off an IQ score for severe cases (22): .
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SARS-CoV-2 contains a novel nuclearization sequence PRRARSV in the spike protein. This is equivalent to the Simian Immunodeficiency Virus SV 40 TAg. Both the spike protein itself and mRNA are found to translocate to the nucleus.
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Whether we all have immune suppression, immune destruction or immune dysregulation, where is public health guidance informing us of the risks of getting any illness under any of these scenarios? Individuals should not be required to figure it out. That is a public health failure.
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@nothxjstlooking
I really hope it made a point to everyone who attended and was on the conference call
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I wear a mask because SARS-CoV-2 is an airborne virus that may ruin the immune system and take control of our cellular machinery to make copies of itself, slowly at first and then more rapidly over time leading to lymphocytopenia in a similar way to untreated HIV.
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The first one is undiluted, straight fecal sample. Positive test.
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Aldosterone-to-Renin Ratio, Alpha-Fetoprotein, Tumor Marker, Ammonia, Amylase, Apolipoprotein B, (Apo-B), B-Type Natriuretic Peptide (BNP), C-Peptide(Blood), Covid-19 Antibody test, Calcium (Blood), Cancer Antigen 125 (CA-125), Carotene (Beta Carotene), Chlamydia and Gonorrhea,
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I wear a mask because I want to limit the opportunities for this virus to evolve and multiply in my body and make me worse faster. I wear a mask because, even more, I don’t want to be responsible for making someone else worse in the same way.
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We should be angry. Implications here for SARS-CoV-2 early puberty and menopause in females (ref at end). We made huge strides in women's equality in the last 60 years. What does it mean for education if women need to start having children earlier because of earlier menopause?
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I wear a mask because our leadership has failed to recognize the similarities between SARS-CoV-2 and HIV, for which we have 40 years of research as
@dbugger
explains often.
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It’s absurd human medicine plays “let’s wait and see” because you’re not dying yet or have cancer yet, even though there are indications of big problems on the horizon, yet I can get proactive investigation for my healthy looking cat with indications of problems on the horizon.
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I hate to recommend a private testing site because this should be happening through our regular providers. It’s wrong to need this. However, I know everyone is desperate for answers and these are providing me valuable information to make my drs move.
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I wear a mask because western govts failed to follow WHO guidance of precautionary principle: n95 grade ppe for health care workers and test/quarantine at ports of entry developed after SARS- CoV 2003 and stop transmission of a slowly disabling SARS-CoV-2 virus.
@RealCheckMarker
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The second is fecal sample diluted in small amount of H20. I didn’t measure how much. Negative test. DON’T DILUTE YOUR SAMPLE.
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The third one is a throat swab. Negative test.
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"The impact is due to the direct biological effects of HIV on the fecundity of infected women, as well as to its indirect effects upon behavior in the general population."
Previous comparisons to HIV have been made.
"Lower fertility amongst HIV-positive women causes a population attributable decline in total fertility of the order of 0.4% for each percentage point HIV prevalence in the general female population."
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@calirunnerdoc
@UCSFMedicine
@StanfordMed
They should lose their license for speaking about patients that way. The callous disregard is disgusting.
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I wear a mask because our govt failed to consult or declined to listen to SARS/CoV experts or epidemiological modelers. We did not have to live with SARS-CoV-2. We haven’t had SARS-CoV 2003 running wild for 20 years. We did the right thing then. Ref and prev:
@RealCheckMarker
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I wear a mask because real public health leadership means being honest about what the reality is for the public so they can adjust and help themselves. I hope you will put on a mask to protect yourself and as I do and advocate for masks in healthcare setting and at schools.
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I strongly encourage you to follow WHO guidelines to protect yourself from this
#Ariborne
#Lymphocytopenia
and
#NDD
causing virus by wearing n95 grade mask and eye glasses/goggles.
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@isuckatwife
Thank you. I don’t know about it. But I think I saw boron w/erythromycin…
@DrDan20000
I think we need some honesty and leadership from traditional medicine so we can come together in some way to help people. This digging around & experimenting everywhere on our own is absurd.
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SARS-CoV-2 has been shown to infect microglia. Indirect effects on behavior in the general population is due in part to infection of the microglial cells in the brain in areas like the hypothalamus and an influx of neutrophils and cytokines causing inflammatory destruction.
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I wear a mask since all member states are committed to following WHO guidelines, but the rule has no enforcement mechanism. We need enforcement tools or these policies are useless. Do we need a state independent organization?
Ref:
@_ppmv
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The best way to protect your brain and immune system from an airborne lymphocytopenia and neurodegenerative disease causing virus is to follow WHO guidance and use n95 grade PPE. It’s a SARS virus, and today, the damage is incurable.
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I wear a mask because I care that we don’t make this any worse for ourselves. Just because it’s here to stay doesn’t mean we need to allow it to be as destructive as it can be. We need to stop variants, which means test and quarantine at points of entry per WHO guidelines.
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Quercitin, an HO-1 inducer, reduced syncytia formation and spike expression
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When 70% of the control group has the same problems as study group, it demonstrates the method used to distinguish between the two failed. No viral load test = no control group. These studies should be retracted. We need a viral load test.
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I’ve done only half the tests. I needed both arms and rest in between because I started to pass out after 8 large vials were taken. 14 vials the first time and we are sick people. I will followup with utility of the minerals and vitamins b/c those were very expensive.
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I wear a mask because it’s the way to prevent genetic recombination of this virus with anything other than what’s already within me.
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I will post tests only as there are some people/accounts that are desperate for that info and not necessarily for benign or helpful reasons. Wasn’t meaning to tease. Wised up after seeing some replies. It’s too bad not everyone is acting in the best interests of others right now.
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My son was just really sick. My husband is getting over being very sick. He’s talking to a co-worker who is sick himself and his child is currently sick. WTF are we doing? And why are our government controlled public health agencies lying? This is a sick joke at this point.
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I wear a mask because SARS-CoV-2 has the opportunity to combine with viruses or viral fragments in the cytoplasm. For example, HIV, mPox and rabies all replicate in the cytoplasm. EBV can stick around with us as can herpes and many others. The possibilities are huge.
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I wear a mask because our leadership either didn’t know or disregarded CoV replication. A virus that replicates in the cytoplasm, has an ORF2p retrotransposon and uses template switching, but which also translocates to the nucleus, is a problem.
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I wear a mask because if these viruses become part of the CoV genome, they may no longer be detectable by standard tests and our vaccines for any of those viruses may no longer be effective. That’s big.
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It’s hard to understand why face masks haven’t always been required in health care settings by everyone. HCW should not endure constant pathogen exposure at work. Patients should not be expected to accept pathogen exposure for medical care.
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Pro soccer player Raphael Dwamena, 28, collapsed on the field and passed from a heart attack.
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This will cause telomeres to become shorter. It is causing our genes to be chewed up. It does this by suppressing retinoblastoma pRb and p53, both tumor suppressing proteins.
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Referenced previously, SARS-CoV-2 infected immune cells access the ovaries. Testing the mitochondrial DNA (mtDNA) of babies born to mothers that have seroconverted prior to pregnancy is one way to determine if SARS-CoV-2 is infecting human ovum currently.
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@jungleswatcher
I think that’s a funny question for a virus is in residence. Reactivation may be more accurate. Thanks for the reply.
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@MSmelkinsonPhD
Are you and your followers aware that despite the damages of distance learning on academics it was far better for children to have intact immune systems and live free from acquired lymphocytopenia, which will shorten their lives?
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@ErinSandersNP
@farid__jalali
@oni_blackstock
I’m in his neck if the woods. He is a trusted source of pandemic information for many of my friends here. He’s far less objectionable in tone to Dr. Monica Ghandi. More palatable version of “don’t worry about them. You do you.”
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I will post results when I have multiple people’s done. It’s not looking great. I’ve been seeing drs near monthly while they watch and wait. No reason based upon info I’ve given. I wonder exactly how many things you can be dying from at once and how we’ll minimize/normalize that?
I just spent $4600 on lab tests to prove drs are allowing us to die. It will cost $13,800 to test the other three adults. I cannot get these tests for my 16yo. That is crushing. I have to hope her drs will do the right thing once they see my and the older girl’s results. 🤞
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The hypothalamus is connected to the pituitary gland and secretes hormones that affect the function and communication between the pituitary gland and the adrenal cortex. It affects the regulation of many homeostatic systems. Damage=dysregulation.
.
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Cellular immortalization or sensesescence is pushing cells past their Hayflick limit of allowed cellular divisions before they undergo apoptosis. Immortalization is like cancer cells where they continue "living" past this limit.
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This is how SARS-CoV-2 forms a histone mimic. It makes a second turn or helix of RNA as a negative strand template. Nsp 8 functions to keep the two strands from separating before replication is done.
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Males have both larger and more microglia. Their microglia are more "on alert" and react faster and more prone to apoptosis. There are memory and behavioral implications.
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Microglia become activated in response to a stimulus. Microglia are targets for viral infection by SARS-CoV-2. They are a very likely reservoir for SARS-CoV-2 in the brain just as they are in HIV.
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@OliveSiffleur
@ChristosArgyrop
@ZekeEmanuel
This sounds like saving $$$ not valuing humanity at all stages of existence. You can freely decide on your own to do this, but why are you promoting this for all? It’s kinda gross. Next step, younger disabled people?
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Males are more likely to display acts of valor or defense upon activation of the microglia. They will become more aggressive.
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@1goodtern
My husband’s dr was honest when his blood sugar was all over the place. Bp/cholesterol is well controlled and blood sugar monitored yearly. “This isn’t normal. Something is wrong with your immune system but I have no idea what to do.”
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So if spike antibodies as measured in the blood are increasing over time, doesn’t that mean the body can’t clear the antigens and they’re increasing causing the antibody levels to continue rising? Strange how it’s like an increasing infection over time.
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@Bexter50
@ErinSandersNP
@farid__jalali
@oni_blackstock
It’s very hard to mount a challenge against the benevolent father figure. More challenging to overcome or even engage his messaging than those that are more confrontational.
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Spike expression up regulates potentially nephrotoxic genes, TNF-alpha, MCP-1, ICAM1.
Up regulates cytoprotective gene Hemeoxygenase-1 & relevant signaling pathways p-AKT, p-STAT3, p-p38.
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At some point it is absurd the comparisons between SARS-CoV-2 and HIV. But with only one of these diseases are we trying to hide what it is.
SARS-CoV-2 perverts the body’s immune system.
It activates T cells that fail to combat the virus directly.
Instead, these T cells contribute to tissue damage without checking viral replication.
SARS-CoV-2 can lead to severe immune dysregulation.
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@joshuamcclure
@MaxwellBiosci
Seems so promising for many illnesses. I hope it comes to fruition. Capable of crossing BBB and getting into csf? Cuz if you can’t get in there, you won’t kick this beast out of me.
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I’m starting to see these falcon emojis turning up near people’s names/x handles. I wonder what those are about? They all seem to support use of ACE2 receptor by SARS-CoV-2 and by extension Long Covid as part of ME/CFS. 🤷♀️
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@Mistsandgrass
@mrmickme
I have long Covid. I always have long Covid. It changes but it doesn’t leave.
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Hematocrit, MCV, MHC, MCHC, RDW, Platelets, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes, Eos (Absoute), Baso (Absolute), Immature Granulocytes, Immature Grans (Abs)
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Michael’s honest. Orgs should rename themselves. They are not Long Covid orgs if they support this and they’re not demanding a viral load test and HIV panel monitoring of disease progression. My disease is not all other illnesses and it shouldn’t be swept under the rug.
Its not a call for long covid, it's a call for all infection associated chronic diseases. Just make sure congress knows you support 12 other diseases because that's what you are doing.
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In addition, the virus is affecting many of our homeostatic feedback control processes. There are many implications related to energy control (ME/CFS), lipid metabolism and behavior.
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Don't dismiss because they found stress induced microglial activation. SARS-CoV-2 and other viruses, it is likely they will find problems with cortisol over/under production will be due to damage by the virus to the system (hypothalamus) controlling cortisol production system.
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Does the CDC plan to explain why we’re suddenly seeing all this TB? Almost like SARS-CoV-2 makes us susceptible to opportunistic infections by destroying the immune system.
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@Bob_Wachter
@NewYorker
@emmaogreen
Hi Dr. Wachter-
SARS=immune dysregulation=very shortened life expectancy. Are your constituents aware you are giving this kind of advice about SARS?
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Total Glutathione, Trichmoniasis, Troponin, Uric Acid (serum), Urinalysis (microscopic examination), Vitamin A (retinol), Vitamin B1, Vitamin B12 & Folic Acid, Vitamin B12, Vitamin B2 (riboflavin), Vitamin B3 (niacin), Vitamin B5, Vitamin B6, Vitamin C
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@Mingle1232
You are a lifesaver to remind me not to post my result for you and only the tests. Thanks! 🙏
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Coenzyme Q10, CBC w/differential, Copper (Blood), Creatine Kinase (total), Cytomegalovirus (CMV) Antibodies IgG, Erythrocyte sedimentation rate, Ferritin Test, Folic Acid, Gamma Glutamyl Transpeptidase (GGT), Glucose 6-phosphate dehydrogenase (G6PD) Quantitative, HIV 1&2 antibody
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This is in reference to the second tweet about effects on ovulation. Both monocytes and macrophages are activated in SARS-CoV-2. These cells rush into the egg during ovulation. If those cells get destroyed/used up, there is no ability to ovulate.
SARS-CoV-2 infects monocytes and macrophages. Ovulation is dependent upon both.
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I don't have full access below. The first phase "lifespan extension" cells proliferating for a limited number of cell divisions. The second phase is immortalization and occurs only in certain cells. Analysis indicates it's a gene inactivating event.
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This article does an excellent job of explaining many of the ways microglia activation are associated with disease and behavior.
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For example, if one is producing a lot of androgen because the negative feedback process is not functioning to inhibit it, there are behavioral implications for society when people become overly aggressive.
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Vitamin D 25-Hydroxy (calcidiol) Blood, Vitamin E, Vitamin K1, Zinc (plasma or serum)
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Lipoprotein (a), Lp(a), Liver Function Test (LFT), Lyme Disease Antibodies, Lymphocyte Subset Panel, Magnesium (blood), Manganese (blood), Mono (mononucleosis), Omega 3&6 Fatty Acids, Prothrombin Time (PT) w/INR, Renal (Kidney) Function Panel, Routine Urinalysis, Syphilis
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HIV RNA, HTLV-I/II Antibody w/reflex to confirmatory assay, Hemoglobin A1c Test, Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis C Virus RNA, Herpes I, Herpes II, Homocysteine Test, Immunoglobulin E IgG, Iron & Iron Binding Capacity (TIBC), Lipase, Lipid/Cholesterol Panel,
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@lisa_iannattone
@PeteUK7
Since some other respiratory viruses can get to the brain, including influenza, maybe we should be much more cautious of those respiratory viruses as well as SARS-CoV-2. I think that statement is backwards.
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The spike is imported into the nucleus with importin a.
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Note: lymphocyte panel is
Absolute CD3, %CD3 Pos. Lymph., Absolute CD4 Helper, %CD4 Pos. Lymph., Absolute CD8 (Supp), %CD8 Pos. Lymph., %CD3+CD25+ Lymphs., Absolute CD3+CD25+ Lymphs., %CD8+CD57+ Lymps., Absolute CD8+CD57+ Lymphs, CD4/CD8 ratio, WBC, RBC, hemoglobin, contd…
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Here is general information SV 40 TAg from Wikipedia. The protein is ideal for studying nuclearization signals.
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Embryos may become infected with SARS-CoV-2 during implantation when the trophoblasts come into contact with the uterine epithelium. The embryo may also contract infection through the trophoblasts in contact with the mother’s blood supply. Trophoblasts are syncytia forming cells.
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Areas of the brain controlling vital neuro-biological processes such as the neuro-endocrine system (hormone regulation).
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The N gene, aka ORF8, in SARS-CoV-2 is the ORF7b from HKU1 with a different promoter sequence. How does that happen?
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We did not need to have this discussion. We could have stopped SARS-CoV 2019 as we did in 2003 if we had followed the
#PrecautionaryPrinciple
. Who should really be agonizing over this incredibly difficult question? These are leadership questions. I hear crickets.
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Our own DNA damage signaling proteins help it remain stable propagate. Inhibiting DNA damage repair and signaling proteins may help.
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