James Nuñez
@jamesknunez
Followers
2K
Following
1K
Media
22
Statuses
385
Assistant Professor @UCBerkeley @czbiohub / CRISPR & epigenetics / 🇵🇭🎾
Joined June 2016
Can’t believe I get to work with these wonderful scientists!
2
1
78
I’m super excited to announce our preprint on Transcriptional regulation of disease-relevant microglial activation programs. To determine regulators of microglia activation states, we performed six transcription factor-wide CRISPRi screens. https://t.co/UHoWo5LyZy
3
5
30
Love this paper! Congrats @JoshTycko et al.
Development of compact transcriptional effectors using high-throughput measurements in diverse contexts https://t.co/ZELzFp9Ivs
1
1
12
Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory.
biorxiv.org
Restriction-modification (R-M) systems, present in most bacterial genomes, protect against phage infection by detecting and degrading invading foreign DNA. However, like many prokaryotic anti-phage...
2
54
163
Join us at @berkeleyMCB! Our faculty search is super broad and I can't speak highly enough about the colleagues and trainees in our department. The deadline is fast approaching, October 31. Please reach out if you have any questions!
We're Hiring! Assistant Professor of Biochemistry, Biophysics, and Structural Biology in MCB. Learn more and apply online: https://t.co/7BiH4BKaAE
0
9
26
Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? https://t.co/xKP9tGFFlQ
11
114
450
MCB is excited to welcome @Ahmad_N_Nabhan as our newest MCB faculty member starting on 1/1/25! https://t.co/FMbuPmHwAA
1
2
32
The Cox Lab is looking for 1-2 postdocs to join us! If you have an interest/expertise in single-cell/spatial transcriptomics, imaging, and/or plant-microbe interactions, I encourage you to apply! https://t.co/25QNd0Qnzq
1
133
157
Beyond proud of @IzaiahOrnelas for being named a Gilliam Fellow @HHMINEWS !! Congrats to all the new fellows 🎉
🎉It's Gilliam Day! 🎉 We're so excited to announce the 2024 #GilliamFellows! These 50 adviser-student pairs are being recognized for their outstanding research as well as their commitments to advancing equity and inclusion in science.
1
11
99
It was a pleasure to host the #HannaGrayFellows at HHMI this week! The retreat was filled with insightful discussions, professional development, and meaningful connections. We look forward to more inspiring collaborations in the future! ✨
0
22
129
Hello, all! Do you know Python? Do you have 10 minutes to help us learn about programmers by participating in an online user study? No scheduling required, just a quick programming activity at this link!
1
15
28
The HuSH complex silences retrotransposons in vertebrates. Our latest manuscript introduces HuSH2 and delves into the fascinating interplay of two paralogous HuSH complexes in governing LINE-1 silencing. Credits to @Zena_Jen and @aechristenson. https://t.co/NMA3kzqHV2.
1
11
72
Excited to share that our team's development of the CRISPR-DREAM platform, led by the innovative @Mahata87, has been published in @naturemethods today! These new CRISPRa systems permit robust, versatile, and well-tolerated engineered gene activation across diverse human cells!
9
22
109
Fantastic day on Lake Tahoe with the Ohainle Lab and the Nuñez Lab at a @berkeleyMCB retreat Thanks for joining us Nuñez Lab!
0
6
39
Are you a postdoc/grad student preparing to launch a faculty search? Have you worked to increase equity & inclusion in STEM? Apply to the 2023 Next Generation Faculty Symposium ( https://t.co/l8ecND7zSl)! RT widely! (1/4) @CZBiohub @Stanford_ChEMH @StanfordBioE @StanfordBioX
berkeleystanfordnextgensymposium.com
5
97
146
I am thrilled to announce that my Lab is moving to the MCB department at UC Berkeley, where I will be an Assistant Professor in Residence and an Investigator for the Chan Zuckerberg Biohub. We have move to fabulous space in Koshland Hall. 1/2
8
11
106
Delighted to share our review on lineage-tracing technologies in cancer biology, now available in Annual Reviews of Cancer Biology! We cover exciting new technologies and applications, and offer a perspective on what's next. We hope you find it useful:
2
29
92
Delighted to post our lab's manuscript! Awesome work by @clarajanae and @amaizeingcorn with help from @Grey_Monroe
Dynamic DNA methylation turnover in gene bodies is associated with enhanced gene expression plasticity https://t.co/ZICBg6zoVg
#biorxiv_genomic
1
18
45
A great resource for CRISPR guide design!
Our crisprVerse paper is out in @NatureComms. We developed a one-stop shop CRISPR gRNA design tool that works with any nuclease and genome, and includes functionalities for CRISPRko, CRISPRa, CRISPRi, base editing, and RNA-editing. https://t.co/4fQPlVtDch
1
3
18
We are excited to share new work from our group at .@UCBerkeley. We characterized hundreds of plant transcription factors, that modulate gene expression to enrich gene regulatory networks. See thread for a summary. #transcription #plantsynbio #systemsbio
https://t.co/cGcjDdwPgE
2
44
173
🚨 New #LoveVirology preprint: This paper has it all: single cells, COVID, CRISPR & Sunshine! We systematically characterize host factors of SARS-CoV-2 using Perturb-seq. Led by @sarasunshinebio, bringing together @JswLab, Joe DeRisi's lab & many others https://t.co/9AXfXKeEYc 1/
Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq https://t.co/44zqk32WFM
#bioRxiv
7
29
119