Thank you @alzforum for featuring our new preprint identifying regulators of disease states of microglia. Project led by @AmandaKMcQuade, computational analysis by @reetm09. Collaboration with the labs of @jamesknunez & Phil De Jager https://t.co/7EJJXOfgpU

Our preprint was recently covered by Alzforum:

3) DNMT1 KD inhibits interferon-responsive microglia likely through hypomethylation of canonical interferon inhibitors.

We selected three regulators to study more deeply and discovered 1) STAT2 KD blocks interferon-responsive microglia as expected, but also impairs lysosomal function. 2) PRDM1 KD drives lipid-rich and DAM states in a tunable fashion and leads to increased phagocytosis...

This rich dataset allows us to infer relationships between states, link new proteins to states, and highlight differences between iPSC-microglia models. We anticipate this data will be useful to selectively drive microglial activation for mechanistic and translational research.

We uncovered both novel and predicted regulators of microglial states and chose 31 transcriptional regulators to study deeper with multimodal, single-cell analysis of the transcriptome and 166 surface proteins in two microglia differentiation approaches.

I’m super excited to announce our preprint on Transcriptional regulation of disease-relevant microglial activation programs. To determine regulators of microglia activation states, we performed six transcription factor-wide CRISPRi screens. https://t.co/UHoWo5LyZy

✨Closing Day 1 of ISMND NextGen 2025... S2: #Apolipoprotein and lipid contribution to #AlzheimersDisease Host: Julia TCW & Margareta Kurkela Speakers: 🔹 Akhil Pallerla 🔹 Amanda McQuade 🔹 Sascha Koppes-den Hertog 🔹 Xu Chen 🔹 Georgia Nolt 🔹 Isaiah O. Stephens

Congratulations ⁦@KampmannLab⁩ post-bacs ⁦@venushagan⁩ and ⁦@researchspencer⁩ on great presentations at the annual ⁦@UCSF_PROPEL⁩ symposium! 👏👏👏 #kampmannlabproud

Today we celebrated @vincentcastllo who has been our @KampmannLab SRA for two years! He accomplished so much in his time here and was an amazing mentor for the newer members of my SRA team. Best of luck to him as he starts his MD/PhD here at UCSF!! 🌟

Happy Valentine’s Day from the @KampmannLab

The Gate lab is thrilled to share our latest publication, online today at @NeuroCellPress. This study was led by two highly talented former research technicians, @abhi19_r and @PiehlNatalie (both now @dgpnorthwestern graduate students). I will outline key findings here:

Join us for the Neurobiology of Brain Disorders GRC in Castelldefels, Spain this August! @izu__u and I are going to be going through abstracts soon, so make sure to get yours in! https://t.co/ktUwCKXmIo

Hey established #Alzheimers #AD researchers, check out this position @UCIrvine, in @UCIneurobio and @UCIMedSchool! Its a great opportunity to join our thriving #neuroscience community https://t.co/FKgCAGMRJe

Should I stay or should I go? Our latest work on human #microglia migration is out on #biorxiv_neursci! Contrary to expectations, ER and SOCE Ca2+ signals don't call the shots. 🧠🔍. Check it out: https://t.co/IxdbxrOmEN ...and there are some nice videos, too! @biorxivpreprint

One man's niche is another man's treasure 😀

I’m thrilled to share the results of a phenomenal collaboration with Lasse Dissing-Olesen in the @stevens1lab. If you’re hungry for microglial biology and looking for a new set of utensils with which to dig in, please read on. https://t.co/DcCb0rtEfN 1/n

We are thrilled to welcome Dr. Morgan Coburn (@Morgan_Coburn) to the CNLM team as our new Neuroscience Outreach and Education Fellow! 🧠🎉

Fantastic preprint on APOE and lipid droplet containing microglia!

Thank you to ISMND for putting together this accessible conference! This has been a great opportunity to share my work and hear many exciting research updates!