Jacob J. Adashek, DO
@jacobadashek
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Med Onc fellow @HopkinsKimmel | Interested in biomarker-driven early phase clinical trials | Avid baker, reader, & sports fan | Tweets = my own
Baltimore, MD
Joined December 2013
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Why don’t all patients respond to genomic-driven therapies⁉️ From 1417 tumor samples we
@UCSDHealth
@Dr_R_Kurzrock
@NantHealth
@szech758
@CharlesVaske
found 13% of mutations in DNA NOT EXPRESSED in RNA! A novel resistance mechanism 👉 in
@JCI_insight
4
89
194
🌟HOT OFF THE PRESS🌟FOR
@ASCO
#GI23
! TARGETED THERAPIES🎯WORK in PANCREATIC CANCER‼️ In
@Nature_NPJ
from
@MCWCancerCenter
@Dr_R_Kurzrock
&
@UCSDHealth
@JShayaMD
@gregorybotta
@JasonSicklick
!
7
48
178
Out now
@NatureMedicine
ARROW trial showing RET-fusion as a tissue-agnostic target🎯! Proud and honored to call
@VivekSubbiah
my mentor & watch the treatment landscape of cancer evolve day by day‼️ Likely to be the next 🧬tissue-agnostic
@US_FDA
approval!
7
49
168
Honored to be the next chair of
@ASCO
@ASCOTECAG
and follow in the amazing footsteps and leadership of
@FernandoDiazMD1
!!!
Very grateful👏🏻for all of the amazing mentors who have helped me along the way
@Dr_R_Kurzrock
@montypal
@VivekSubbiah
@jgong15
@JadChahoud
@GlopesMd
❤️
Congratulations! I look forward to meeting everyone at the ASCO Annual Meeting
#ASCO24
. 🏆Congratulations to
@jacobadashek
for being selected as the next chair of the
#TECAG
🏆. I look forward to working alongside you!
2
7
44
25
22
143
Thrilled, honored, and humbled to be invited to serve as a member of
@ASCO
Trainee & Early Career Advisory Group and learn from
@ramsedhom
@AnaVManana
@ADesaiMD
and many more‼️
18
5
129
Out today in
@nature
@NatureCancer
our
@Dr_R_Kurzrock
@USFIMres
@AlexeyGoloubev
commentary about biomarker-driven🧬🎯 clinical trials in 💊oncology‼️
#PrecisionMedicine
1
39
110
Multi-omic analysis for patients with CUP! Our
@MCWCancerCenter
@Dr_R_Kurzrock
@UCSDHealth
@JasonSicklick
study previously presented as an oral presentation
@myESMO
#ESMO20
out now in
@MolOncology
! A Tweetorial 1/8
4
36
108
I love to bake and mention it in my
@twitter
bio… I should share with the twitterverse what I’m bringing for my
@hopkinskimmel
inpatient solid oncology team tomorrow! Chocolate chip walnut banana bread 😎
12
6
100
Matched combination (lenvatinib + palbociclib) therapy for FGFR and cell cycle-altered osteosarcoma benefits 51+ MONTHS and ONGOING with
@Dr_R_Kurzrock
@VivekSubbiah
! Molecular alterations drive cancer. Slay the hydra, cut off all the heads!
4
39
92
So excited to be in
@hopkinskimmel
@Hopkins_HemOnc
clinic with Ravin Garg! The man is a savant and hematology-oncology encyclopedia! He personally wrote >2500 questions for high yield boards!
5
11
87
Proud to share our
@MoffittNews
study on fear of cancer recurrence among survivors in
@ESMO_Open
! On the eve of day 1 of
@Hopkins_HemOnc
fellowship! Would not be here without the supreme mentorship from many special people, feeling so grateful!!
8
16
86
🔥NEW READING🔥 Significant independent association between high LAG-3 expression and high expression of PD-L1, PD-1, & CTLA-4, TMB-H‼️ in
@CancerMedicineJ
with
@MCWCancerCenter
@Dr_R_Kurzrock
@DHMCandClinics
@HirotakaMd
@OmniSeq
2
27
85
OUT NOW in
@CancerBiologyTx
w/
@MCWCancerCenter
@Dr_R_Kurzrock
,
@umichneuro
@RushiSJoshi7
,
@Amelie_Boichard
>9100 tumor samples, AMPLIFICATIONS may be potentially actionable🎯 secondary consequences of TP53🧬 mutations‼️
0
30
81
🌟HOT OFF THE PRESS🌟 in
@JAMAOnc
with
@MayoHemeOnc
@ADesaiMD
,
@LombardiCancer
@Joshua_Reuss
,
@cityofhope
@JackWestMD
,
@MayoClinic
@AMansfieldMD
our REVIEW on perioperative ICIs in early-stage NSCLC‼️ Read🤓it here:
3
27
80
🔥Out now in
@OncologyAdvance
Cancer Treatment Reviews w/
@MCWCancerCenter
@Dr_R_Kurzrock
@UCSDHealth
@JasonSicklick
, "If it’s a target🎯, it’s a pan-cancer🧬target🎯: Tissue is not the issue"🔥
3
39
79
@Dr_R_Kurzrock
would never toot her own horn so as a proud mentee I will! I am so honored & grateful to work with and be mentored by her! She now has 900 peer-reviewed papers contributing so much to cancer care research & continues helping countless patients! Here’s to 900 more!
2
11
75
@VivekSubbiah
with another
@US_FDA
AGNOSTIC APPROVAL!
@Dr_R_Kurzrock
says “If it’s a target, it’s a pan-cancer target” The needle moves forward & patients can get new therapies! RET-fusions are targetable REGARDLESS of histology!
1
32
73
🌟EXTRA, EXTRA! READ ALL ABOUT IT🗞️In
@NatureCancer
"Considering molecular alterations as pan-cancer tissue-agnostic targets" w/
@MCWCancerCenter
@Dr_R_Kurzrock
@JasonSicklick
‼️ If it's a target🧬🎯, it's a pan-cancer target🎯: Tissue is NOT🚫 the issue🔥🔥
4
20
74
2 years ago we
@ChrisSzetoPhD
presented our data from
#TCGA
and
@NantHealth
@ASCO
-
@sitcancer
! Today it is published in
@ESMO_Open
! Grateful for the unparalleled mentorship from
@Dr_R_Kurzrock
! Targetable gene alterations impact the expression of IRMs!
7
18
71
Dr Pat Lo Russo
@YaleCancer
delivers one of the best lectures I have ever witnessed in my life
@ASCO
@AACR
MCCR23!! A true visionary and legendary oncologist and human being! ❤️ honored to have been in the audience to experience
0
10
73
🌟OUT TODAY in
@JCOPO_ASCO
🌟with
@MedicalCollege
@Dr_R_Kurzrock
! HER2 protein and mRNA expression and amplifications among 5,305 diverse cancers is HIGHLY VARIABLE‼️
20% (144/723) of patients had mRNA overexpression with negative CNV and IHC!
3
25
70
So glad to support
@cityofhope
@montypal
for the nominating committee in the
@ASCO
elections!
Monty’s bedside manner and patient care is what I still try to emulate today. He is an exceptionally generous and thoughtful leader! I hope you’ll support him at the polls on 11/2!
1
26
70
🔥HOT🔥OFF THE PRESS📰in
@JAMAOnc
w/
@StElizabethNKY
@MatthewKurianMD
@Summitplc
@JackWestMD
"Cancer Care in the Era of Artificial Intelligence🖥️" helping patients navigate cancer care in the era of AI‼️
0
21
68
Having such an amazing experience at
@ASCO
@AACR
Methods in Clinical Cancer Research Workshop!! Awesome to see
@lauracmichaelis
@DrEzraCohen
and listen to some amazing lectures this morning!
1
9
67
On the eve of
@ASCO
@sitcancer
#ImmunoOnc20
@RosenShingleCr
thrilled to share our opinion on HPD in
@trendscancer
@CellCellPress
with mentorship from
@MDAndersonNews
@IshwariaMD
@VivekSubbiah
and collaboration from
@VHIO
@MatosIgnacio
@ElenaGarralda
!
4
52
66
Patients with concomitant Cyclin ➕ MAPK/MEK-related gene alterations🧬 benefit from combination approach‼️ Out today in
@CCR_AACR
@AACR
our paper led by
@UCSDHealth
@Dr_R_Kurzrock
#ShumeiKato
@JasonSicklick
‼️
4
24
64
🌟HOT OFF THE PRESS🌟in time for the weekend‼️ By the incredible
@OslerResidency
Amol Gupta,
@MCWCancerCenter
@Dr_R_Kurzrock
in
@Cancers_MDPI
our review on🎯targeted🧬therapies in cholangiocarcinoma‼️
'Is Cholangiocarcinoma the🫁‘NSCLC’ of GI Oncology'⁉️
1
29
63
Ok now hear me out. I bought the muffin baking cups, but forgot I didn’t bring a muffin tray when I moved. But life is about pivoting, this is a pivot: blueberry muffin .. bread. It’s a blueberry muffin bread. Enjoy your weekend twitterverse!
6
5
63
Shana tova! Sweet🍯, happy, and healthy🍎 new year to those near and far in the Twitterverse❤️!
4
5
63
BRAF V600 mutations in non-melanoma and responses to BRAF +- MEK inhibitors
#AACR21
with
@VivekSubbiah
@ADesaiMD
! An actionable target outside of melanoma! Potentially agnostic marker?
@AACR
2
23
62
Signed in Blood🩸 Our
@WIN_Consortium
@Dr_R_Kurzrock
&
@MonteRosaTx
@FilipJankuMD
review on the ctDNA🧬 in cancer diagnosis, treatment, and screening in
@MDPIOpenAccess
@Cancers_MDPI
‼️
1
20
60
@MoffittNews
take on integrating somatic and germline NGS into practice in
@ASCO_pubs
with
@USFIMres
@Atandondoc
@RandaPerkinsMD
@EdmondoRobinson
!
#PrecisionMedicine
#precisiononcology
1
35
59
Unbelievably proud of what he has done and what he will do!! Unparalleled mentorship from
@VivekSubbiah
now launched🚀🚀 to transform
@SarahCannonDocs
Early-Phase!! Can't wait to see what the future will bring🌟🌟!! See you
@ASCO
#ASCO23
!!
2
8
59
🌟HERE FOR WEEKEND READING🤓!!🌟 Our
@MedicalCollege
@Dr_R_Kurzrock
@DartmouthCancer
@IvyLorena_Md
@adityasharmaMD1
comprehensive review in
@MDPIpharma
on all things ADC in solid tumors!
"An Effectiveness Payday💰💵with a Targeted🎯Payload💣"! ‼️
0
20
56
🌟JUST OUT🌟 Our perspective in
@MedCellPress
with
@MDAndersonNews
@BlessieNelson
@StevenLin_MDPhD
@VivekSubbiah
on the abscopal☢️effect in patients with cancer receiving immunotherapy🧬and how we can maximize it's utility‼️
0
25
56
OUT IN
@JIPOEditors
w/
@Dr_R_Kurzrock
@AaronGoodman33
, PD-1 TILs PREDICT RESPONSE TO ICB‼️ PD-1+ TILs in tumors associated w/ ⬆️mPFS (7 v 1.9 m;p=0.006) & ⬆️OS (18.1 v 8 m;p=0.04) post-ICB. Time to stop staining for PD-L1 and start staining for PD-1 TILs❓
3
23
56
My first TWEETORIAL about an organization that I feel so passionately about and am so grateful has taken me under their wings
@targetcancer
with the world's 1st virtual molecular tumor board (vMTB) clinical trial TCF-001 TRACK focused on rare cancers! 1/8
2
23
56
A whirlwind of a week filled with phenomenal lectures, thought-provoking group sessions led by
@DrMhidalgo
, amazing views, and new friendships that I hope will last a lifetime✨
@ASCO
@AACR
#MCCR23
you exceeded all expectations and I am so grateful to have had this experience♥️
0
10
56
Day 1 of
@Hopkins_HemOnc
orientation in the books! Such a packed day and thrilled to be here with
@pdzavras
!! Looking forward to what tomorrow will bring! Bone marrow biopsy training with
@Dr_BDSmith
and more!!
0
6
56
Proud to share our
@MDAndersonNews
@IshwariaMD
systematic review ➡️ on the experience of caregivers of older adults
#gerionc
with
#Cancer
in
@ESMO_Open
‼️ Grateful to have learned so much with this🤓!
1
24
54
Why don't many patients respond to single-agent CDKi⁉️ 99% have additional co-alterations (median 4)‼️ In our study
@JCI_insight
led by
@UCSDHealth
@Dr_R_Kurzrock
#ShumeiKato
@JasonSicklick
patients w ⬆️ matching score (≥50%) had ⬆️ PFS and SD ≥6m rate‼️
1
25
52
Very grateful for
@sitcancer
Forward Fund Travel Award✈️and can’t wait for a great week at Cancer Immunotherapy Winter School! Looking forward to learning a lot!🤓
7
1
52
Our patient with NET and PD-L1/PD-L2 AMPLIFICATION and HIGH TMB on
@swog
DART trial in
@ASCO_pubs
#JCOPO
led by
@CSCancerCare
@jgong15
@DrHendifar
@AGangiMD
and
@UCSDHealth
@Dr_R_Kurzrock
@PatelOncology
!
1
26
50
Friday morning walk into work
@Hopkins_HemOnc
@hopkinskimmel
@HopkinsMedicine
show me how your work day starts! 🙌🏻
4
5
49
🌟PRECISION ONCOLOGY AT ITS BEST🌟with
@hopkinskimmel
@DocSeiwert
in
@Nature_NPJ
our patient achieved a DURABLE, COMPLETE RESPONSE with alectinib for her ALK-fusion🧬metastatic salivary ductal carcinoma‼️ Is ALK another tissue agnostic target🎯⁉️
2
17
49
Amazing complete and durable (>300 days) response to selpercatinib in a patient with RET-fusion breast cancer!
#PrecisionMedicine
@VivekSubbiah
@Dr_R_Kurzrock
@alexdrilon
0
22
48
Very grateful to have been mentored by
@UCSDHealth
@Dr_R_Kurzrock
@MDAndersonNews
@DavidHongMD
@YaleCancer
#LoRusso
on our perspective in
@NatRevClinOncol
about Phase 1 trials being therapeutic!
2
15
46
Excited for
@myESMO
#ESMO20
tomorrow with our
@UCSDHealth
@Dr_R_Kurzrock
oral presentation on PERSONALIZED🧬 GENOMIC-MATCHED COMBINATION💊 TARGETED🎯 therapies for patients with CUP‼️ Tune in on-demand tomorrow❗️
2
17
46
Out now in
@sitcancer
#SITC2020
with
@Dr_R_Kurzrock
@AlexeyGoloubev
"Immunotherapy trials lack a biomarker🧬🎯 for inclusion ➡️ implications for drug💊 development‼️"
Only, 37 (~9%) of 413 trials were planned requiring a biomarker for enrollment (n = 5,602 of 57,853; [9.7%])‼️
1
17
45
NSAID use in pts w mRCC receiving ICI ➡️ higher risk of progression (HR 1.52; 1.04–2.22; p=.031) and death (HR 1.60; 1.02–2.52; p=.04)‼️ Read it in
@Cells_MDPI
with
@MoffittNews
@JadChahoud
@MoffittGUOnc
@SpiessPhilippe
@MoffittHemOnc
@yumengzhang2009
0
18
46
Our,
@Dr_R_Kurzrock
and
#ShumeiKato
from
@UCSDHealth
@RobertoFerrara_
from
@IstTumori
, evidence-based commentary in
@OncJournal
on hyperprogression
#HPD
and immune checkpoint inhibitors
#ICI
in cancer.
1
22
44
Our review
@CSCancerCare
@jgong15
collab
@EllisLab
@HyungLKim
@SFreedlandMD
@NeilBhowmick1
@EdwinPosadasMD
@breuniglab
on 1L mRCC ICI combos‼️ Figure inspired by
@cityofhope
@montypal
chalk talk, title inspired by
@JoyceCarolOates
in time for
@ASCO
#GU22
!
2
23
44
Our
@MCWCancerCenter
@Dr_R_Kurzrock
@UCSDHealth
@zacksurg
findings: LAG-3 transcriptomic expression correlates linearly with other checkpoints, but not clinical outcomes‼️ High LAG-3 levels do NOT predict resistance to anti-PD-1/PD-L1 checkpoint blockade‼️
0
14
44
Just finished 2 weeks of inpt solid onc
@hopkinskimmel
, motivation to do better for our patients. Makes me think about
@GavinPrestonMD
showing how much you care. Tonight I share with the twitterverse one of my favorites of all-time, mandelbread that I made tonight!
@Dr_R_Kurzrock
6
2
43
Out today in
@CurrentOncology
our
@VeronicaMollica
@fmassari79
@IstTumori
@RobertoFerrara_
@HopkinsMedicine
@MentaArjun
🧬review on genomics/immunomics of
#BladderCancer
‼️ Many evolving and promising targets🎯 and therapies on the horizon‼️
0
17
43
Our
@UCSDHealth
@Dr_R_Kurzrock
@MDAndersonNews
@VivekSubbiah
paper in
@CellPressNews
@trendscancer
on the
#precisiononcology
🎯paradigm ➡️ tissue-agnostic🧬 and n-of-1 💊therapies‼️
3
26
43
🌟Proud to share our review🌟 "On target🎯methods to induce abscopal☢️phenomenon for Off-Target effects: From happenstance to happenings" with
@MDAndersonNews
@BlessieNelson
@StevenLin_MDPhD
@VivekSubbiah
in Cancer Medicine‼️
0
13
41
Very excited, honored, and humbled to be the guest editor for
@MDPIOpenAccess
@Pharmaceut_MDPI
for a special issue on ICI! Please take a look and submit here! This is a PubMed indexed journal with rising impact factor, latest >5‼️
0
10
42
Incredibly grateful to work with and be mentored by
@MDAndersonNews
dynamic duo
@IshwariaMD
&
@VivekSubbiah
on our
@EricTopol
-inspired paper on AI assisting oncologists! “Resist and Desist or Enlist and Co-exist?”
2
10
41
Such a great time with
@IvyLorena_Md
and
@ADesaiMD
@GoHealio
awards and
@cancerGRACE
dinner! Hard to believe I’ve known them for over 2 years and finally met this weekend!!
#ASCO22
@ASCO
1
3
41
Incredibly grateful to
@OncLive
for featuring me to promote tumor-agnostic approvals and specifically the new BRAF V600E approval! Continue the
#PrecisionOncology
paradigm! “Get the right drug to the right patient at the right time” -
@Dr_R_Kurzrock
WATCH:
@jacobadashek
, of
@hopkinskimmel
, discusses how targeting molecular alterations is key for treating multiple types of cancer.
0
5
7
1
14
42
Coming soon- the
@targetcancer
Think Tank on Advancing Precision Medicine in Rare Cancers, in Boston on 9/21! Featuring an amazing agenda including talks by
@Dr_R_Kurzrock
@VivekSubbiah
and many more. Learn more and register for free here:
2
16
42
So thankful to be
@ThrivewellSa
Luncheon and meet
@TheSTARTCenter
&
@ASCO
Board of Directors
@RodriguezGIMD
!
Such an amazing organization doing phenomenal things!!
(And
@spurs
Coach Popovich in the background🏀)
3
8
41
Very grateful to be able to work on this paper with
@MoffittNews
@SpiessPhilippe
@JadChahoud
@MoffittGUOnc
@AydinAMurat
and
@IstTumori
@AndreaNecchi
in
@NatRevUrol
on the genomic and immunomic landscape in penile cancer!
0
13
39
"Mismatch meets its match 👉 Marriage between dMMR and ICI" in
@OncJournal
by
@UCSDHealth
@Dr_R_Kurzrock
@MDAndersonNews
@VivekSubbiah
‼️ ICIs were in almost every tumor
@ASCO
#ASCO20
How do we get the right drug, to the right patient, at the right time⁉️
0
12
40
Our take on expanding the role of
#PrecisionMedicine
with gene-targeted CANCER drugs in NON-CANCEROUS conditions in
@GenomeMedicine
! Forever grateful to my brilliant mentor
@Dr_R_Kurzrock
@UCSDHealth
!!
0
19
39
Having another amazing day
@asco
@AACR
MCCR23
#VailWorkshop
with my good friends
@AnoutiBilal
@FawziAbuRous
!
0
2
40
🌟HOT🔥 off the press
@Nature_NPJ
w/
@MCWCancerCenter
@Dr_R_Kurzrock
🌟Home-run trials: giving the right🧬drug💊to the right🫂patient in the right🏡place‼️ Access to an academic center shouldn't be a limiting factor for patients to get on a clinical trial‼️
5
15
39
Our
@MoffittNews
@DrJusChadha
@AdeleSemaan
@MonteWakeIM
@hsafaMD
@sgilbert1973
@WadeJSexton9
@SpiessPhilippe
@JadChahoud
analysis of PROs in 1L mRCC trials in Clinical Genitourinary Cancer journal!
0
8
39
~15% of mutations found in NGS are NOT expressed at the RNA level! Work from
@UCSDHealth
@Dr_R_Kurzrock
@immunitybio
@NantHealth
@szech758
presented at the
@NCCNMeetings
@NCCN
#virtualmeetings
posted online today! Peruse >100 other posters here!
2
19
38
Great insights about older vs younger patients treated for mRCC from
@MDAndersonNews
@OncHahn
@cityofhope
@NazliDizman
@montypal
@huntsmancancer
@neerajaiims
@maughanonc
@umangtalking
!
2
17
38
Last weekend in Tampa enjoying my first cup of joe with my
@Florez_Lab
mug!! Many thanks to the amazing
@NarjustFlorezMD
!
2
2
38
Can't wait for
#ASCO23
! Humbled, honored, and excited to be a Featured Voice! Helping you keep up to date in real-time on all things novel drugs, biomarkers, and early phase studies!
4
2
38
Thrilled and honored to be an
#ASCO22
Featured Voice! I'll be tweeting about
#DevelopmentalTherapeutics
,
#immunotherapy
and
#clinicaltrials
!
1
4
37
🌟Out now in
@ESMO_Open
w
@MedicalCollege
@Dr_R_Kurzrock
@TMDUniversity
@IkedaMD
@purduepharmacy
@han_banan_18
@UCSDHealth
@JasonSicklick
, Targeting the FGF/FGFR axis and its co-alteration🧬allies! FGF/FGFR alterations v w/o had⬇️OS, but can be🎯to⬆️OS! 🌟
1
13
35
My take on
@levainbakery
walnut chocolate chip cookies😎 Wishing the twitterverse a happy and healthy holiday season and new year!🎁☃️🧣
@Dr_R_Kurzrock
what do you think, how did I do?
7
2
36
Always a great start to BMT🩸wards when my 🇬🇷 Greek brother
@pdzavras
brings in special Greek desserts🤩!!
2
4
36
@VivekSubbiah
showed today
#AACR2021
that targeting RET can yield response in multiple tumor types!
@ADesaiMD
@andreevdrakhlin
and I found that in NSCLC with RET fusions, KRAS is significantly co-altered! A potential combination in RET fusion NSCLC??
@AACR
1
19
33
Grateful to chat with my group leader and workshop chair
@DrMhidalgo
for career and life advice
@ASCO
@AACR
MCCR23!
0
4
35
Incredibly grateful for the opportunity to work on our manuscript in
@OncologyAdvance
describing the evidence and decision-making strategy based on second-generation p-values (SGPV) under the mentorship of
@PavlosMsaouel
@MDAndersonNews
!
1
13
33
Who did it better😇☺️?! Comparing and contrasting Figures 1 from NRG1 papers from 2020
@CCR_AACR
& 2024
@BMCMedicine
from our paper!
Honestly, I love the tactfulness & clarity! vs. 😁
@Dr_R_Kurzrock
, what do you think?
3
7
34
Is there a role for cytoreductive nephrectomy in sarcomatoid mRCC⁉️ The
@MoffittNews
experience led by
@SpiessPhilippe
@JadChahoud
@LoganZemp
@yumengzhang2009
@alyssabilotta
in
@FrontOncology
‼️
0
12
34
We
@MCWCancerCenter
@Dr_R_Kurzrock
looked at CSF1R expression and found NO Δ in PFS, OS between ⬆️ vs. ⬇️ expressers & in pts who received CSF1Ri‼️
All CSF1R ⬆️ samples also had ⬆️ ≥ 2 immune checkpoints (e.g. PD-1, PD-L1, PD-L2, CTLA4, LAG3, TIM3)‼️
0
12
32
Can I join the
#ASCO22
#ASCOiSpy
@ASCO
party?
@NarjustDumaMD
@GlopesMd
@CharuAggarwalMD
@fumikochino
@AnaVManana
@VivekSubbiah
@AmandaBinDC
2
2
33
As my time winds down w last few days in Tampa, reflecting on the last 3 yrs. I will absolutely miss q6weeks continuity clinic with
@JadChahoud
@MoffittNew
! Jad graciously allowed me to spend 2 yrs in his clinic and is a supportive, wise, thoughtful mentor and friend! So grateful
1
1
33
In
@BMCMedicine
w/
@MCWCancerCenter
@Dr_R_Kurzrock
@hopkinsneurons
@NicholasMaraga1
, "NRG-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis (ALS) and cancer" with successfully targeting HER2/3 for an NRG1-fusion!
2
9
32
Just in case you thought I didn’t bake anything for the holidays🎁🕎
@Dr_R_Kurzrock
@AmandaNizamMD
@NicoleKuderer
🎄here are my 7-layer bars I just took out of the oven☕️😉
5
7
30
In
@ESMO_Open
led by
@UCSDHealth
@zacksurg
@gregorybotta
@JasonSicklick
@Dr_R_Kurzrock
@DartmouthCancer
@HirotakaMd
,🕶️Viewing the immune checkpoint VISTA‼️ ⬆️VISTA correlates with⬆️BTLA,⬆️TIM-3,⬆️TNFRSF14 &⬇️poorer post-ICI survival in pancreas cancer‼️
1
10
32
Out today in
#OncoImmunology
with
@MedicalCollege
@Dr_R_Kurzrock
,
@AmbryGenetics
, &
@konicaminolta
‼️ Serial liquid🩸biopsies🧬PREDICT OUTCOMES to ICI from ∆VAF at ~2⃣-3⃣ weeks of therapy across PAN-CANCERS‼️
1
14
32
Honored to join the advisory board for
@CureMatch
! Love this initiative and getting the right drugs to the right patients at the right time!!
1
5
32
How can we logically combine targeted therapies and immunotherapies⁉️ 23 significant associations were found between highly 🎯targetable 🧬mutations and IRMs in over 5700 samples, REGARDLESS of TISSUE‼️
#tissueagnostic
#precisionmedicine
3
16
31
🌟Now in
@CancerMedicineJ
w/
@Dr_R_Kurzrock
🌟"Pan-cancer analysis of TIM-3 transcriptomic expression reveals high levels in pancreatic cancer and interpatient heterogeneity"‼️⬆️TIM-3 is significantly and independently correlated with⬆️PD-L1 &⬆️CTLA-4‼️🔥🔥
3
11
31
Does cytoreductive nephrectomy have a role in sarcomatoid clear or non-clear cell RCC? Our work
@AACR
#AACR20
by
@MoffittGUOnc
@MoffittNews
@SpiessPhilippe
@JadChahoud
!
1
13
31
Our
@UCSDHealth
@Dr_R_Kurzrock
take on balancing⚖️ levels of evidence in
@NatureBiotech
‼️Lessons🤓 we learned from a pandemic‼️
0
13
31
After 4 years it feels so good to be back in person
@UCSDHealth
with Dr Kato! He is one of the best mentors I could’ve ever dreamed of!
@Dr_R_Kurzrock
2
4
29
Beyond grateful for the opportunity to work with
@UCSDHealth
@Dr_R_Kurzrock
on this
#ShumeiKato
@nature
@NatureComms
#precisiononcology
MOLECULAR🧬 TUMOR BOARD ➡️ MATCHING SCORE🎯 study‼️
1
9
30
Mixed responses and overcoming resistance by cutting off the heads of the hydra! Such a great effort in
@Annals_Oncology
under the amazing mentorship of
@Dr_R_Kurzrock
@VivekSubbiah
! Very thankful to
@FAndreMD
to accept our paper! Check out the pre-proof !
“The Lernaean Hydra was a monster in Greek mythology. It had many heads and every time someone would cut off one of them, two more heads would grow out of the stump. In order to slay the Hydra, Heracles cut off all off the monster’s heads and burned the neck.”
@Annals_Oncology
0
3
12
1
11
29