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ESMO Open

@ESMO_Open

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The Open Access journal of @myESMO dedicated to oncology research

Joined September 2015
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@ESMO_Open
ESMO Open
6 days
Laboratory Prognostic Index (LAB-PI) in DLBCL: a single blood analysis predicts outcomes as good as IPI, NCCN-IPI, and GELTAMO-IPI in @ESMO_Open. High LDH, low Hb & high B2M predict prognosis of newly diagnosed DLBCL. https://t.co/UEqLKr2jcV
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@ESMO_Open
ESMO Open
6 days
Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial in @ESMO_Open. Robust activity in MSI CRC, limited in MSI-Like MSS. https://t.co/MSmjzHRrOf
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@awxjack
Jack Zhang
2 days
Stripe offered to acquire us for $1.2 billion when we had $2M in revenue. Today, we've raised $330M at an $8B valuation and reached $1B ARR. We could've died three times during this journey. This is the story I've never told anyone before:
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@ESMO_Open
ESMO Open
6 days
Long-term effect of neoadjuvant denosumab treatment in high-risk early breast cancer (GeparX) in @ESMO_Open. Short-course denosumab is associated with reduced distant relapse risk, warranting further exploration. https://t.co/i57uKFdeum
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@ESMO_Open
ESMO Open
6 days
Radiomic signatures to estimate survival in patients with advanced HCC treated with sorafenib: Cancer and Leukemia Group B 80802 (Alliance) in @ESMO_Open. AI-driven radiomic-clinical model can accurately predict OS as early as 10 weeks into treatment. https://t.co/QoFJGU4sS6
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@ArndtVogel
Arndt Vogel
11 days
2nd-line 5-FU + NAIRI vs FOLFOX/XELOX in metastatic #PADC after gem—nab-pacli: propensity score-matched analysis @ESMO_Open https://t.co/n1g0vROoUo 👉mOS 7.2 vs 5.8 mo 👉mPFS 3.0 vs 2.5 mo 👉more side effects for Naliri 🧐still devastating poor outcome, we need to do better...
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@denofwolvesgame
Den of Wolves
6 days
The plan was clean. The escape? Not so much. Midway City doesn’t play fair. Wishlist this 4-player coop heist FPS on Steam today.
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@ESMO_Open
ESMO Open
16 days
Outcomes of ICI rechallenge in advanced urothelial carcinoma: results from a global RW evidence study in @ESMO_Open. Retrospective data suggesting some patients could benefit from this treatment. Different ICI sequencing may act differently. https://t.co/ogaBwkSWzl
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@ESMO_Open
ESMO Open
16 days
Pembrolizumab plus chemotherapy vs chemotherapy for advanced esophageal cancer: 5-year extended f-up for the randomized phase III KEYNOTE-590 study in @ESMO_Open. Durable efficacy of chemo-IO, 5-yrs survival rate of 10.6% vs 3.0% & no new safety signals. https://t.co/yYvHt9NmJh
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@ESMO_Open
ESMO Open
1 month
Meta-analysis of surrogate endpoints for overall survival in extensive-stage small-cell lung cancer in @ESMO_Open. PFS shows strong correlation with OS in 1L trials, while neither ORR nor DCR predicts survival. In 2L, DCR correlates with PFS but not OS. https://t.co/rnEJCAfJBy
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@ESMO_Open
ESMO Open
1 month
Phase II trial of enfortumab vedotin in patients with previously treated gastric and esophageal cancers in @ESMO_Open. EV shows activity especially in patients with esophageal squamous cell carcinoma, with expected safety profile. https://t.co/68WpG9bbCH
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@JoinCrowdHealth
CrowdHealth
9 days
Our average cost per month for CrowdHealth hit its lowest EVER in 2025!!! $140.42/month for singles <55 (down 13% vs '24) $225.83/month for singles 55+ (down 17% vs '24) $476.25/month for families of 4 (down 11% vs '24) If you are looking for an affordable alternative to health
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@benjiwal
Benjamin Walbaum, MD
2 months
Just ahead of #ESMO25 Our new paper in @ESMO_Open shows that short preoperative ET provides a low-cost, RW tool to assess endocrine sensitivity in ER+ BC Achieving CCCA (Ki67 ≤2.7%) predicts better outcomes (HR 0.19). 🧬 Dynamic biomarkers matter. 🔗 https://t.co/ISR1cuRpTT
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@ESMO_Open
ESMO Open
2 months
Venous thromboembolic event risk with PARPi in solid tumors: a systematic review and meta-analysis in @ESMO_Open. Potential small increased VTE risk, influenced by cancer subtype (higher in pancreatic and prostate cancers) and treatment combinations. https://t.co/kJqOm6xxwT
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@ESMO_Open
ESMO Open
2 months
AI defines spatial patterns of TILs highly associated with outcome – a pan-GI cancer study in @ESMO_open. Spatial TIL-tumor patterns, tumor nuclei shape & texture features on HE WSI as top prognostic features across GI tumors, with generalizability in CRC. https://t.co/oQxNnRoDlq
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@ESMO_Open
ESMO Open
3 months
The rising tides of cancers among young adults in @ESMO_Open. Global rise in early-onset cancers among young adults. This growing trend is a critical scientific challenge requiring an urgent comprehensive in-depth investigation. https://t.co/42MWp1j1xF
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@AlgoFoundation
Algorand Foundation
8 days
Don’t be the one who missed algoland Finish your remaining quests and lock in extra entries for the grand prize
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@ESMO_Open
ESMO Open
3 months
Durvalumab after RT in pts with unresectable stage III NSCLC ineligible for CT: the DUART ph II nonrandomized controlled study in @ESMO_Open. Well tolerated Tx in this frail population. Encouraging activity signals, molecular remission in some cases. https://t.co/ed1TjhEtzM
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@ESMO_Open
ESMO Open
3 months
Plasma cfDNA analysis of alectinib resistance-related gene alterations in the J-ALEX study in @ESMO_Open. cfDNA NGS analysis enables early resistance detection and guides personalized ALK TKI therapy. https://t.co/f908Vw8yka
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@ESMO_Open
ESMO Open
3 months
FGFR1-amplified colorectal cancer: a distinct prognostic subtype identified through integrated genomic and IHC profiling in @ESMO_Open. CRC FGFR profiling (n=7,606) spots aggressive FGFR1-amp tumors. Possible screening by novel IRS IHC method. https://t.co/NpiOzoc7k0
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@ESMO_Open
ESMO Open
3 months
Network analysis of NRG1 VUSes in advanced NSCLC and their prognostic role in EGFR-mutant pts treated with 1L osimertinib in @ESMO_Open. 8% of pts harbour NRG1 VUSes, 57.1% with oncogenic alterations. Potential poor prognostic factor in EGFR+ subgroup. https://t.co/6WVE6bTEye
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@tuttsakhil
Dr Akhil Santhosh MD DM MRCP(UK)
4 months
Durvalumab after radiotherapy in patients with unresectable stage III non-small-cell lung cancer ineligible for chemotherapy: the DUART phase II nonrandomized controlled study @ESMO_Open
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esmoopen.com
Currently, patients with unresectable stage III non-small-cell lung cancer (NSCLC) ineligible for chemotherapy receive radiotherapy alone, with unsatisfactory results. DUART was a phase II single-arm...
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@tuttsakhil
Dr Akhil Santhosh MD DM MRCP(UK)
4 months
Neoadjuvant chemotherapy with FOLFOXIRI for high-risk relapsed locally advanced colon cancer: a single-arm phase II trial @ESMO_Open
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esmoopen.com
To evaluate the safety and deliverability of neoadjuvant chemotherapy (NAC) with three-drug-intensity chemotherapy [oxaliplatin, irinotecan, and fluorouracil (FOLFOXIRI)] in patients with high-risk...
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@tuttsakhil
Dr Akhil Santhosh MD DM MRCP(UK)
4 months
Improving chemotherapy-induced peripheral neuropathy in cancer patients using a combined qigong and self-administered acupressure intervention: a randomized controlled trial - @ESMO_Open
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esmoopen.com
Acupressure and qigong are Chinese medicine-based modalities that can work in synergy to improve chemotherapy-induced peripheral neuropathy (CIPN). This study examines the effect of a combined qigong...
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