In recognition of #BreastCancerAwarenessMonth, we’re highlighting our recent publications: https://t.co/aOUDD4YAci https://t.co/hvtPPjUJBi https://t.co/x3KrWfowkR @LiuCluster @DKFZ @Krebshilfe_Bonn

Is the answer to increasing vaccine responses right under our noses? John V. Williams & team @uwsmph study a nasal IFN production in a mouse model of human metapneumovirus, reporting on the downregulation of nasal IFN production with infection and the ability to bolster mucosal

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JCI Insight - Carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation

CRB3 and NF2 orchestrate cytoskeletal dynamics to control epithelial barrier assembly

The proteins that hold your gut together… @Parkos_Nusrat @saranya_raajan & team @UMichMedSchool report on CRB3 and NF2 as a dynamic duo that control epithelial barrier assembly: https://t.co/YkSoS5wcEw The figure shows murine colonic tissue sections labeled for CRB3A (green),

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Not sure who's still on this platform but here's to finally getting my first ever postdoc project out. We add to existing evidence that Tfh cells in humans are highly heterogeneous and show a subtype of Tfh1 cells correlate with antibodies in malaria.

Does Vitamin D protect against kidney injury? Here, @waikarss @DavidLeaf9 & team @BrighamWomens conduct a phase 2, randomized, double-blind, multi-dose, 3-arm clinical trial in critically ill adults. While treatment with calcifediol or calcitriol upregulated genes in several

Join us for ASCI Scientific Session on November 10th: Brian K. Kobilka discusses his career as a physician-scientist with mentor and Nobel co-laureate (2012) Robert J. Lefkowitz @robertjlefkowi1 Register: https://t.co/KIojYCS3KQ

From earlier this week: The Geneva Consensus recommends live mycobacterial vaccines against TB include at least 2 independent gene knockouts to ensure attenuation. Here, Deepak Kaushal & team @txbiomed generate double and triple knockout mutants in Mtb, performing safety tests

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Sharing this again: Thyroid hormones are important for neurodevelopment during the first trimester of pregnancy. Here, @FedeSalasLucia & team @UChicago model suboptimal thyroid hormone levels during the early stages of cerebral cortex development, revealing an unappreciated role

Co-phagocytosis of VEGFA with HER2-overexpressing cancer cells induced by HER2-VEGFA–bispecific antibodies improves antitumor responses

A co-phagocytosis strategy for metastatic cancer! Zhen Fan & team @MDAndersonNews validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model:

Prenatal SMN-dependent defects in translation uncover reversible primary cilia phenotypes in spinal muscular atrophy

Treatments for spinal muscular atrophy have improved quality of life and increased lifespan, but neurodevelopmental comorbidities are now becoming apparent. Here, Thomas H. Gillingwater & team @EdinburghUni reveal in utero delivery of SMN-restoring therapy corrects

Thrilled to share this publication out now in @JCI_insight. Completed in the @drummond_lab at @UUtah, we leveraged acute hypoxia to enhance macrophage immunometabolism and improve muscle recovery following disuse atrophy in aged mice. https://t.co/meWa7A5efP

Defining endotypes of bronchopulmonary dysplasia in preterm infants to improve precision-based therapies This Review by Megha Sharma et al. @UArkansas provides a historical context for BPD definitions and highlights the potential for endotype-based treatments:

Macrophage metabolic rewiring rejuvenates muscle Raman signatures and cellular remodeling during regrowth in aged mice

How can we rejuvenate muscles? @zfennel @drummond_lab & team @UUtah show enhanced #MuscleRecovery after muscle loss from disuse in mice—old and young—by reprogramming proinflammatory macrophages into a younger state using transient hypoxia: https://t.co/oQ1rj2zZqm

#VitaminD deficiency associates with increased risk for a broad range of medical conditions. Yet RCTs of Vitamin D replacement often fail to show therapeutic benefit. Here critical illness and risk of acute kidney injury https://t.co/qn2fcXC7HK @JCI_insight