JCI insight
@JCI_insight
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High-quality basic & translational research representative of biomedical specialties & physician-scientists. Bluesky: https://t.co/AksMLnE2WS
Joined October 2016
Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS In this Research Letter, Nadir Yehya & team @ChildrensPhila assessed 24 children with #ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls:
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Overcoming resistance to immune checkpoint inhibitors remains a major objective in #cancer Here, Richard Bucala @BucalaRichard & team @YaleMed show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma and colorectal cancer mouse models:
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New 3i Investigator Article Alert!! Carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation
pubmed.ncbi.nlm.nih.gov
Mammalian skin wounds typically heal with a scar, characterized by fibrotic tissue that disrupts original tissue architecture and function. Therapies that limit fibrosis and promote regenerative...
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JCI Insight - Carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation
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I have good genes. BUT, Dragonfly's are better IMHO/ @sydney_sweeney No?
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Site-1 protease–mediated cholesterol metabolism is essential for lymphatic development in mice
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Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism. Here, Lijun Xia & team @OMRF generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development:
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Congrats to @LaitilaJenni & colleagues for their new @JCI_insight paper: Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy.
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Why don’t Catholics attend Holy Mass? Below are the percentages of CATHOLICS that attend Mass WEEKLY by nation: - Netherlands: 7% - France: 8% - Switzerland: 11% - Germany: 14% Out of every 100 Catholics in the Netherlands: only 7 attend Mass weekly?!!! What happened? Scandal?
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Bcl6 expression is associated with a distinct immune landscape and spatial transcriptome in COVID-19
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In utero rescue of neurological dysfunction in a mouse model of Wiedemann-Steiner syndrome
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Wiedemann Steiner syndrome is a rare genetic disorder, but whether it could be reversed in mice, as some other epigenetic conditions, had never been tested. Here Hans T. Bjornsson @BjornssonL Tinna Reynisdottir @tinnareynis & team @uni_iceland generated a WDSTS mouse model and
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Why do they care so much that RFK Jr is not a doctor when they never cared before?
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Shared earlier this week: Is the answer to increasing vaccine responses right under our noses? John V. Williams & team @uwsmph study a nasal IFN production in a mouse model of human metapneumovirus, reporting on the downregulation of nasal IFN production with infection and the
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This paper made it to the top of our readership list: Icosapent ethyl–induced lipoprotein remodeling and its impact on #CardiovascularDisease risk markers in normolipidemic individuals https://t.co/HOG1vD1cee
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A potential new target in inflammatory bowel disease! Agnieszka K. Czopik & team @UTHealthHouston use advanced techniques, including a tdTomato-labeled mouse model, intestinal organoids, and RNA sequencing to reveal the microRNA miR-147 protects intestinal integrity during
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Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions
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Does faith belong in the public square? At Truth & Liberty, we say yes. Follow us for bold conversations about faith, freedom, and family values.
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Peanut extract increases phosphorylation of RPS6 in peanut-allergic blood, but the clinical importance was unclear. Florent Fauchère & team @ChariteBerlin now show basophil-released histamine induces RPS6 phosphorylation in dendritic cells; and this phosphorylation correlates
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Rapid cyclic stretching of cultured human visceral smooth muscle cells promotes a synthetic, proinflammatory phenotype
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A stretch for gut cells extends our understanding in #BowelDisease Robert O. Heuckeroth & team @CHOP_Research subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: https://t.co/gZme5biZky The
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BMC Chief of Nephrology @waikarss and @BrighamWomens researcher @DavidLeaf9 found that Vitamin D treatment, using either calcifediol or calcitriol, had effects on the immune system but did not prevent acute kidney injury in critically ill patients.
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2 years ago veteran endurance athlete, Kurt Madden, was given a few pouches of VESPA. Initially he blew it off, but due to the persistence of his friend Mike McKovitch, he decided to give it a whirl on a training brick (bike/run) and his world changed . . . . . . fast forward to
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In recognition of #BreastCancerAwarenessMonth, we’re highlighting our recent publications: https://t.co/aOUDD4YAci
https://t.co/hvtPPjUJBi
https://t.co/x3KrWfowkR
@LiuCluster
@DKFZ
@Krebshilfe_Bonn
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