Nicole Kuderer, MD, MS, FASCO ๐๐บ๐ธ๐ช๐บ๐บ๐ฆ๐
@NicoleKuderer
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Oncologist & Big Data Science (Translational SuppOnc, Toxicity Outcomes Research), #COVID19 ; @OncoAlert ; FASCO, ASCO Biomarkers. โLet's make a difference".
USA
Joined November 2017
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Why we need large, prospective patient cohorts to identify the clinically meaningful biomarkers: not only w detailed molecular high-throughput assessment, but also detailed patient response & tox data. (Longitudinal data needed to find resistance markers.)
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โญ๏ธ๐งฌโญ๏ธPrivilege of a lifetime to be mentioned by
@NatRevClinOncol
that selected our acute Chemo
#Tox
as its article of the year of
@AACR
#AACR23
collection and a wonderful team of collaborators
@gary_lyman
@ADesaiMD
@DianaNrco
โญ๏ธ
@OncoAlert
@SWOG
@AACR_CEO
@AACRPres
@crisbergerot
Here are some great reads to make the best of your
#AACR23
experience.
@NatRevClinOncol
has contributed to this comprehensive collection with a Review on
#toxicity
from
@gary_lyman
@NicoleKuderer
@ADesaiMD
and
@maryam_lustberg
0
9
15
43
53
131
@bogda_koczwara
@Nature
@gary_lyman
@CELL
@FrancescoSche20
@kevinpunie
@DrJFriedberg
@EthicsdoctorP
@jamecancerdoc
@maryam_lustberg
@stolaney1
@WilliamDale_MD
@rochgerionc
@manalipatelmd
@PatelOncology
@g_mountzios
@GGiannarini
@curijoey
@darioT_
@MdBosserman
@aftimosp
@jillfeldman4
@double_whammied
@DrTJM_MD
@adrianakahnmd
@PamelaKunzMD
@JasmineSukumar
@ADesaiMD
@BeckiLee
@LisaHicksMD
@IBCResearch
@chemobrainfog
@cierrasisters
@stage4kelly
@swaggsheila1
@JaniceTNBCmets
@paspears88
@DrSusanLove
@DraAnaCasas
@icthicmagazine
@ErikaHamilton9
@NeliMUlrich
@MikkaelSekeres
@FAndreMD
@shilpaonc
@DrDawnHershman
@connors_md
@LeonidasPlatan1
@PavlosMsaouel
30/
@gary_lyman
& I so grateful for all the kind & special well-wishes โจ๐โจ. Thank you for the love & offer to help that has come our way, and cannot tell you how appreciated it is. Please ALL stay
#COVID19
safe & thx for masking & spreading safety needs for our vulnerables pts
65
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โญ๏ธ So honored to be asked by
@NatRevClinOnco
Collaborate Toxicity
#DreamTeam
, incl
@ADesaiMD
,
@maryam_lustberg
and
@gary_lyman
explain acute chemo Tox ๐๐ป
Survivorship & patient voice also in near future๐๐ป
@curijoey
@OncoAlert
@cczielinski
@jamecancerdoc
@fniainle
@DrJFriedberg
In a Review now online,
@NicoleKuderer
,
@ADesaiMD
,
@maryam_lustberg
and
@gary_lyman
explain the most common acute toxicities in patients with cancer receiving chemotherapy and discuss management options:
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1/ Racism โ talk & video about killing a fellow Congresswoman ๐:
โRepublican Rep. Paul Gosar from Congress after he posted an edited video showing him killing Congresswoman Alexandria Ocasioโฆโ
@gary_lyman
BREAKING: Calls to expel far-right Republican Rep. Paul Gosar from Congress multiply after he posted an edited video showing him killing Congresswoman Alexandria Ocasio-Cortez. RT IF YOU THINK GOSAR MUST BE REMOVED FROM OFFICE!
944
18K
35K
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๐Cancer Consortium Launches COVID-19
#CCC19
๐Registry in Urgent Appeal for Data to Save Lives at Risk From Infection. Help us spread the word
@OncoAlert
@hemoncwarner
@gary_lyman
@mtmdphd
@GlopesMd
@PGrivasMDPhD
@DrChoueiri
@StoverLab
@TiansterZhang
2
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#OncoAlert
Just announced:
@UWMedicine
is suspending all routine follow-up visits.
Also has started to do
#COVID19
drive-thru testing for staff to get them quick answers if they exposed anybody.
7
24
81
#OncoAlert
BREAKING NEWS out of Netherlands Inst of Public Health: โResults of random sample test: 4% of hospital staff infected with
#COVID19
.โ
ME: Please protect your vulnerable patients & your institutions. Test staff.
@MichaelStaehler
@BenWestphalen
6
49
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@OncoAlert
Important
#Covid19
study in
@LancetLongevity
to confirm that older pts w/ cancer with adapted IMWG frailty score (comorbidities, PS, older age) finds a very vulnerable population for severe
#Covid19
& death.
@ArielleElkrief
@tanyawildes
glad to help make this a reality
In the
@COVID19nCCC
study, we adapted the simplified IMWG frailty score and showed that the highest risk group (older, poorer PS, more comorbidities) of older adults with cancer had markedly increased risk of severe COVID outcomes and death.
#gerionc
2
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Hang on to your loved ones๐ tightly. Don't risk family thru too much work, etc. Life can change things any second. Thank you all for your great holiday tweets & many more private messages. Helped us get thru a young cousin running out of
#cancer
tx options.
#Wisdom
@fredhutch
5
8
76
@OncoAlert
Find out at
#OncoAlertColloquium
what your risks are with 1-2 comorbidities (~1.8 and ~3.9) and chemotherapy (~1.8) chemo-immune (~2.3). Why we need immune correlates to find pts not protected from vaccines & more.
@DJPinato
@ACortelliniMD
@matteolambe
@M_Tagliamento
To end up Day 5โฃ of the
#OncoAlertColloquium
๐จ
The Amazing
@NicoleKuderer
giving us and update on
#COVID19
and
#Cancer
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75
100 labs that may be able to help Ukrainian Scientists ๐. You can add your lab name to this life google document. Let's create one for Russian scientists too. 300 spoke up already. Their lives are at stake too!
@gary_lyman
@weoncologists
@weldeiry
@VoglNY
@CCortiMD
@OncoAlert
There are well-over 100 labs that may be able to help Ukrainian Scientists. Here is a link to the google sheet of Labs Supporting Ukrainian Scientists:
@OncoAlert
@weoncologists
@FrontOncology
@eLife
@Nature
@AACR
@TheCancerLetter
@theNCI
@AmericanCancer
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@ASCO
Dr. Arti Hurriaโs motto:
โIf you want to go fast, go alone, but if you want to go far, go together.โ
0
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@AccountableGOP
Compromise: A key feature of democracy. It ensures all sides get heard and that not one side rules all aspects.
GOP has abandoned this concept since Newt Gingrich. We need to realize this is 'White-Supremacy' now leveraged by all parts of the GOP (white or otherw)
#SaveDemocracy
1
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#TurningBadintoGood
๐โจ๐ซ Be the change:
๐Avoid patient labels
๐Donโt dismiss pts symptoms - Iโve found 80-90% highly important - the rest is important psychosocially at min
๐Major Red Flags: Pts is in at out of hospital or has unexplained worsening organ dysf
#Disparities
1
20
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4
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๐จ๐ Please RT or Donate โฅ๏ธ๐บ๐ฆ
CARE great refugee organiz. 90% goes to help. 1-5 million expected in
#Ukraine
. My family will never forget help ๐๐ป & Yours?
@gary_lyman
@OncoAlert
@FaltasLab
@chadinabhan
@shilpaonc
@stolaney1
@thenasheffect
@DrTJM_MD
@amerseburger
@g_mountzios
Urgent action is needed to avert a looming humanitarian catastrophe in
#Ukraine
. CARE has partnered with
@people_in_need
to provide emergency assistance to the people of Ukraine affected by this crisis.
2
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Quote (2) of the Day ๐Kamala Harris On Saturday๐
โCongressman John Lewis, before his passing, wrote: โDemocracy is not a state. It is an act.' โWhat he meant, was that Americaโs democracy is not guaranteed. It is only as strong as our willingness to defend it"
@gary_lyman
0
8
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@ASlavitt
Dear patient advocates: Please be aware what is happening in Congress ๐on pre-existing conditions. This likely affects every cancer pt & survivor.
@double_whammied
@IBCResearch
@stage4kelly
@RandallBroad
@metavivor
@chemobrainfog
@SWOG
@METUPorg
@ESchattner
@DrAttai
@DrSusanLove
1
42
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โจMissing In-Person Meetingsโจ
Remember one of the most wonderful individuals in
#bcsm
cancer. If you don't know
@naborala
you need to get to know her. She is also a fantastic scientist!
@OncoAlert
@itsnot_pink
@itsthebunk
@gary_lyman
@double_whammied
@stacywgray
@coffeemommy
3
11
63
@Dr_RShatsky
This is what happens when the normally amazing CDC does not get to do its job ๐๐ผ
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#ESMO18
@alexdrilon
: โThe pie keeps getting more & more subdivided.โ It is getting difficult to explore potentially clin impactful rarer biomarkers in a single tumor.
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#VailWorkshop19
- The amazing Dr. Von Hoffโs final year mentor advice:
1) Time is precious
2) Make them dream big
3) Keep your own big dreams
4) Teach โem all you know
5) Pay all the praise & support forward - so they will do the same
It is an honor to be able to attend
#VailWorkshop19
- especially in Dr Von Hoffโs final year where he gave a tremendous reflection lecture rich with advice
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@Dr_RShatsky
So very sorry to hear you & your whole family has
#Covid19
after 3-yrs fully free!! Exactly what happened to most our friends now. Bivalent booster is not โcutting itโ already. I so hope they make updated booster soon ๐๐ป๐๐ป!
Hope you feel better soon !!
3
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Outstanding
@marklewismd
reminding us about the Mukherjee Formula of the โWhyโ all of us can get cancer:
#SCHD19
@btfoundation
1
17
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๐ซโจ๐Whatever you may Celebrate ๐โจ๐ซ
@gary_lyman
and I are sending you this ๐ Light ๐ from our home to yours. May it shine very bright this holiday season & all throughout โจ 2021 โจ.
#MerryChristmas2020
๐๐โ๏ธ๐
@OncoAlert
@ADesaiMD
@SWOG
@double_whammied
@fredhutch
12
5
54
1/ Minimization of Toxicities:
@oncology_bg
so well said. Probably the most important language bias for our ptsโ health is the incredible minimization of tox. If we misjudge the tox impact on patientsโ lives, we also misjudge the balance of benefit vs harms
#WeeklyMusings
#90
4
17
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#OncoAlert
@OncoAlert
Just had an amazing experience & energy with a wonderful โarmy of patient advocatesโ who are going to change the world! From awareness to research funding & beyond ๐!
What say you
@BettinaRyll
@weoncologists
@double_whammied
@corrie_painter
@JFreemanDaily
3
12
53
โจSuch a terrific collaboration on patient-provider communication challenges about Side-effectsโจ
Thank you
@DFCI_BreastOnc
for highlighting and such a terrific team
@Drsarahsam
@jane_meisel
@fumikochino
&
@darioT_
et alโจ
cc
@gary_lyman
@kevinpunie
@crisbergerot
@chemobrainfog
#SABCS23
| Poster PO3-12-05 | Patient-provider communication challenges about side effects/toxicities from
#MetastaticBreastCancer
(
#mBC
) treatments.
@drsarahsam
@jane_meisel
@NicoleKuderer
2
14
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3
20
52
#OncoAlert
Wish could describe the urgency senior Italian ๐ฎ๐น oncologists urge us to be much more
#COVID19
proactive:
Despite screening >50 thousands: still >12-14% in ICU fully overwhelming a good systemโฆSocial distancing appears key now!
@senpattykuderer
@PergamIC
@JayInslee
4
20
52
#ESMO19
#oncoAlert
Dr Rugoโs elegant PD-L1 IHC assay analysis in IMpassion130
#bcsm
atezo study:
๐SP142 FDA approved: smallest N of pts, but most responsive subgr w single assay
๐Other IHC: PFS / OS โฌ๏ธ
๐2 pos IHC: PFS / OS โฌ๏ธ (correlates w TILs+)
๐Mets<<Primary PD-L1+
0
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@OncoAlert
๐ฏCOVID-19 and cancer: A review of the registry-based pandemic response [Sep 2, 2021] Congrats
@ADesaiMD
@DrTJM_MD
et al.
@JAMAOnc
!! Key collaboration with
@DJPinato
@marinagarassino
@OnCovid1
@mtmdphd
. Let's do it again.
@gary_lyman
@g_mountzios
@shilpaonc
@PergamIC
Delighted to be part of this initiative
@mtmdphd
@ADesaiMD
@Ecquis
@marinagarassino
@NicoleKuderer
@peters_solange
through
@OnCovid1
@ImperialSandC
@ImperialBRC
@ImperialAHSC
0
2
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Congrats
@VivekSubbiah
for a beautiful presentation on โFrom Tissue-Agnostic to N-of-One Therapies: Evolution of the Precision Oncology Paradigmโ as well as use of poetry from Chapmanโs Homer. We are looking forward to
@PatelOncology
at tomorrowโs Grand Rounds.
1
11
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1/ My wish for
#ASCO21
: We can have respectful but have real discussions. To quote Emerson: โLet me never fall into the vulgar mistake of dreaming that I am persecuted whenever I am contradicted.โ
โ Ralph Waldo Emerson
@gary_lyman
3
12
47
My hope for 2019
#12
: Oncologists will become aware of the two main
#gerionc
trials that confirm that the majority of older pts value QOL > over longevity considerations when making Tx decisions.
(Senior leads
@ArtiHurriaMD
@rochgerionc
(Together w
@EnriqueSoto8
@MelissaLoh21
)
4
20
46
#Mentorship
Advice: The people who take the time to give you detailed feedback with constructive suggestions are your helpers... ๐ค
@gary_lyman
@crisbergerot
@ADesaiMD
@YLeyfman
@kgunturuMD
@shilpaonc
Deep
#Mentorship
Advice: Good to fix the booboos during study design and manuscript development processes. And before publication ...๐
@gary_lyman
0
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#ESMO19
you have a new spot in my โค๏ธ! Not just a phenomenal
#cancer
conference ๐, fantastic science๐; most importantly many practice changing THERAPIES ๐๐งฌimproving survival for patients โผ๏ธ Thank you my dear friends &
#OncoAlert
for making it particularly memorable ๐ฅฐ!!
3
9
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#ASCO2019
#OncoAlert
Plenary discussant Dr
@yzafar
:
โWe must make the invisible visible.โ
โWe must engage & advocate especially our policy makers.โ
@weoncologists
@oncology_bg
@double_whammied
@gary_lyman
@EnriqueSoto8
@ASCOPres
@cierrasisters
@OtisBrawley
@chadinabhan
@arkhaki
The Affordable Care Act virtually erased racial disparities in access to timely cancer treatment. A worthy opening plenary โฆ
@ASCO
โฉ
@ASCO19
โฆ
@fredhutch
โฉ โฆ
@SWOG
โฉ
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15
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0
22
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Well said Vivek. If your mentor / advisor does not do this ๐, change is in order. You are not supposed to be perfect. You are supposed to learn & be advised, supported and guided.
#Mentorship
@ADesaiMD
@ArielleElkrief
@shilpaonc
@rochgerionc
@WilliamDale_MD
@NarjustDumaMD
1
10
43
Patient Advocates - important message - here is your opportunity at
#MASCC19
@CancerCareMASCC
if you can travel, or maybe they could do live-video?
@double_whammied
@IBCResearch
@itsnot_pink
@itsthebunk
@DrSusanLove
@TPollastro
@METUPorg
@metavivor
@MpBCGA
@bccww
@chemobrainfog
@Martha__Carlson
Thnx for raising this important matter. We value & want to include the patient voice. We have reached out to survivorship orgs, with no response to collaborate. Would be grateful for someone to attend the debate & tweet to share with the community. Please DM us for info.
13
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#SABCS20
Well said
#bcsm
&
#COVID19
risk factors for death: Older age, PS (+1: HR>2, +2: HR>5), comorbidities (1-2: HR>3, 3+: HR>5), progressive dz.
Caveat: Therapy data not yet definitive (needs greater details).
#TNBC
likely collinear w Tx.
@OncoAlert
@SABCSSanAntonio
@arkhaki
Wonderful work led by
@arkhaki
and
@NicoleKuderer
re:
#COVId19
outcome among
#bcsm
patients.
Glad to see type of therapy not making a big difference. Looks like performance status, comorbidities, and cancer state having more effect.
#SABCS20
@OncoAlert
0
9
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1
27
43
โFive Feet Apartโ might be the even better women as heroine movie this weekend?
Also a good one for med profession to remember the imp of human touch. A woman who defies nihilism & typical disillusionment & changes the world around her. See what you think
0
4
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Forever grateful to Dr.
@PergamIC
. He is our key clinical ID 'strategist' at the
@fredhutch
. Our guiding light through
#COVID19
& who is working tirelessly (hopefully not too much!). Thank you & safe 2022 โจ๐โจ!
@gary_lyman
@mshadman
@RolandBWalter
@drjgauthier
@BhatiaS_MD
1
5
42
โค๏ธFeeling incredibly grateful & honored of having found my husband
@gary_lyman
not only a wonderful soulmate but also intellectual male counterpart. I knew you would still do amazing things, but even I could not realize how muchโค๏ธ
Happy Anniversary โค๏ธ Love & Gratefulness alway
6
2
42
#SABCS19
If you donโt know this man you need to get to know him:
Dr Hyman Muss, an icon in
#bcsm
&
#geriatric
breast
#cancer
& superb human being ๐บ.
@minasedrakmd
your name came up a lot โบ๏ธ!
@OncoAlert
@SABCSSanAntonio
2
12
42
Terrific
#ESMO21
Take Home Messages on potentially practice-changing
#BCSM
&
#LCSM
data by no other than
@PTarantinoMD
๐and
@ADesaiMD
๐!
Additions ?
@stolaney1
@ErikaHamilton9
@prat_aleix
@kevinpunie
@matteolambe
@JavierCortesMD
@DrSGraff
@PatelOncology
@Alfdoc2
@StephenVLiu
4
14
42
๐ซ๐๐ Whatever you may Celebrate๐๐๐ซ
As Tiny Tim said: "A Merry
#Christmas
to us all; God bless us. Everyone ๐๐๐!"
May the Light of Christmas bring hope, health, joy, love, friendship, and all you wish for โจ๐๐๐ซโจ
@ADesaiMD
@DrTJM_MD
@aparna96
@thenasheffect
@SWOG
๐ซโจ๐Whatever you may Celebrate ๐โจ๐ซ
@gary_lyman
and I are sending you this ๐ Light ๐ from our home to yours. May it shine very bright this holiday season & all throughout โจ 2021 โจ.
#MerryChristmas2020
๐๐โ๏ธ๐
@OncoAlert
@ADesaiMD
@SWOG
@double_whammied
@fredhutch
12
5
54
1
7
41
@gary_lyman
@bogda_koczwara
@Nature
@CELL
@FrancescoSche20
@kevinpunie
@DrJFriedberg
@EthicsdoctorP
@jamecancerdoc
@maryam_lustberg
@stolaney1
@WilliamDale_MD
@rochgerionc
@manalipatelmd
@PatelOncology
@g_mountzios
@GGiannarini
@curijoey
@darioT_
@MdBosserman
@aftimosp
@jillfeldman4
@double_whammied
@DrTJM_MD
@AdrianaKahnMD
@PamelaKunzMD
@JasmineSukumar
@ADesaiMD
@BeckiLee
@LisaHicksMD
@IBCResearch
@chemobrainfog
@cierrasisters
@stage4kelly
@swaggsheila1
@JaniceTNBCmets
@paspears88
@DrSusanLove
@DraAnaCasas
@icthicmagazine
@ErikaHamilton9
@NeliMUlrich
@MikkaelSekeres
@FAndreMD
@shilpaonc
@DrDawnHershman
@connors_md
@LeonidasPlatan1
@PavlosMsaouel
@crisbergerot
๐ซโค๏ธ Family always comes first โค๏ธ๐ซ
"Rest is not idleness, and to lieโฆunder trees on a summerโs day, listening to the murmur of the water, or watching the clouds float across the sky, is by no means a waste of time.โ
So very glad you made it to our belated vacation ๐๐ป๐๐ป
6
2
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1/ In
#2020
, a special labor of love for Drs.
@ADesaiMD
,
@arkhaki
, & I to write this commentary in
@JAMAOnc
to discuss a key
#COVID19
article of EHRs Use to Estimate Risk, Risk Factors &
#Disparities
for pts w
#COVID19
&
#Cancer
๐
cc
@OncoAlert
@gary_lyman
@SWOG
@fredhutch
Use of EHR to assess risk, disparities amongst pts with cancer and
#COVID19
- fantastic commentary in
@JAMAOnc
@ADesaiMD
@arkhaki
@NicoleKuderer
@COVID19nCCC
1
6
10
2
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40
Gender bias: Great data d/t societyโs models. Both (wo)man are socialized men have final say. If not, esp men but both genders can get uncomfortable. If you experience anger d/t a challenge or suggestions by a woman & yet rarely if by a man๐ definitely bias. Please work on that.
OUR NEW STUDY out
@JAMAInternalMed
is on personal attacks & sexual harassment of physicians on social media.
Authors on
#MedTwitter
here and 1st author med student ๐๐ฝ
@traependergrast
&
@ShikhaJainMD
@MDaware
@MikeGisondi
@ShikhaJainMD
@NikiWoitowich
11
125
344
1
18
39
@deborahcollyar
@itsthebunk
@stage4kelly
@CancerCareMASCC
@double_whammied
@IBCResearch
@itsnot_pink
@DrSusanLove
@TPollastro
@METUPorg
@metavivor
@MpBCGA
@bccww
@chemobrainfog
@maryam_lustberg
@coffeemommy
@stales
@subatomicdoc
@AshleySumrallMD
@corrie_painter
@jillfeldman4
@JFreemanDaily
@womenofteal
@MyelomaTeacher
@SpiveySandra
@nickdawson
Engaging patient advocates is a win-win โ you are like a partner in a marriage โ if your needs are ignored things are definitely going in the wrong direction :) So letโs be sure we hear & learn about your needs...๐น
7
18
39
@Cihan_Ay_MD
@drkomanduri
@TraintoESMO
@science_wallet
@BeckiLee
@maryam_lustberg
@OncoAlert
@gary_lyman
@DrTJM_MD
@ADesaiMD
@adrianakahnmd
@JasmineSukumar
@YLeyfman
@crisbergerot
@jacobadashek
@M_Tagliamento
@matteolambe
@GGiannarini
@lisaksheldon
@DarcyBurbage
@darioT_
@WilliamDale_MD
@FaltasLab
@weldeiry
@ACortelliniMD
@DJPinato
@LisaHicksMD
@BenChinYee
@oncology_bg
@jamecancerdoc
@thenasheffect
@fedgiugliano
@jesusanampa
@DrJNaidoo
@MdBosserman
@VivekSubbiah
@stacywgray
@kevinpunie
@curijoey
@BianchiniGP
@Icro_Meattini
@ScaltritiLab
@LauraMarandino
@ChristianRolfo
@DrRBarroso
@CarmenCalfa
@MassimoDiMaio75
@bogda_koczwara
@viviphi_ashbury
8/ Beautiful Italy & friends โจ๐ฎ๐นโจ
Despite amazing nature, food & Mediterranean climate (incl palm trees growing along the mountains), the best part is still the friends โจ๐โจ!!!
Shana tova - wonderful, peaceful, healthy new year ๐ฏ๐โฅ๏ธ we keep working at it ๐
@cczielinski
4
3
40
1/ My beloved US - This is not a drill. You still don't realize what you are in for. Ingenuity won't help. You are following an old playbook. Listen to these hardened Republican operatives (who gave us BUSH & PALIN). If they actively compaign against him, all Republicans should.
Former Republican Presidential Candidate leaders at
@ProjectLincoln
Wiki: "Schmidt warned that a 2nd term with Trump would be "unrestrained and validated."[4] Steslow saying he will "vote blue no matter who."
@gary_lyman
@connors_md
@GaryRaskob
@HPKiem
0
2
7
2
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39
๐WOW๐
#ASH21
#AntiRacism
Discussion Session - what can โฆ
@ASH_hematology
โฉ do - audience interacting w ASH leaders:
๐May contemplate to score all study submissions by diversity, inclusion
๐Audience also discussing how scared all are to say wrong things & to be vilified
1
10
40
Powerful Quotes๐Amanda Gorman๐
"If not afraid, then youโre not paying attention. The only thing we have to fear is having no fear itself โ on what weโve lost..."
@gary_lyman
@PavlosMsaouel
@Dr_AmerZeidan
@profevasegelov
@DrSharonBober
@VamsiVelcheti
2
15
38
๐ฎ๐น Italy a little more relieve coming from ๐ฉ๐ช per the evening news ๐. ICU planes it is! We ๐ช๐บare with you Italy ๐ฎ๐น.
@ICTHIC
@AnnaFalanga19
@matteolambe
@darioT_
@curijoey
@APassaroMD
@Alfdoc2
@prat_aleix
@PTarantinoMD
@DrSarcoma
@cdanicas
@AndreaNecchi
@Daniel_J_George
World BEST medevac for COVID patient.
Germany activates their flying ICU plane, an Airbus A310 MedEvac, to fly corona patients from Italy to hospitals in Germany. The plane has a capacity of 44 beds of which 16 are for high intensive care patients, and up to 25 medical staff.๐ฒ๐ฒ
1K
42K
70K
2
5
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@EricTopol
Have to look at study, but โplant-basedโ also means higher socioeconomic strata (ie also many better social determinants of health etc) ๐so if they didnโt do detailed adjustment for these factors thatโs a major part of it. Then diet may or may not help some
@gary_lyman
1
0
38
Such an honor to help guide
@ASCO
guideline recommendations such as for
#cancer
-associated
#VTE
. Feeling very fortunate to have trained with key leaders in health outcoms research/evidence-based methodologies as well as translational clinical trials on both sides of the Atlantic.
Updated
@ASCO
guideline on venous thromboembolism prophylaxis & treatment in patients with cancer includes recommendations on the use of direct oral anticoagulants
#VTE
#SuppOnc
#oncology
#VisualAbstract
3
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39
This sign needs to be in every hospital, clinic, office, store, restaurants, etc:
โThe whole world is short staffed be kind to those who showed upโฆโ๐น
This year we need to be even kinder, more generous & forgiving than last yearโฆ
@gary_lyman
@double_whammied
@fredhutch
@swog
0
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#ESMO19
#OncoAlert
Sobering Dr Chia reminding us that we have not improved overall survival (OS) in advanced
#bcsm
(recent exception CDK4/6 inh) over last decade ๐
2
20
36
#ESMO19
#OncoAlert
Dr Harbeck excellent summary of non-metastatic HER2+
#bcsm
:
Key message re Neratinib: 40% serious diarrhea for 1y in adj setting is unacceptable. Limit at most, Neratinib to high risk ER+ women, where maybe there is a clin meaningful benefit in this subgr.
2
22
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@OncoAlert
CoVID-TE Score for
#VTE
in hospitalized
#COVID19
&
#Cancer
N=2804
@AngLi_MD
@JTH
:
๐Risk Factor: Cancer type +1, VTE history +2, ICU adm +2, D-dimer elevated +1, recent systemic anti-cancer Therapy +1, non-Hispanic +1
๐VTE / ATE: 7.6% / 3.9% overall (ICU higher)
CoVIDโTE Risk Model for VTE in Hosp pts w Cancer & COVIDโ19 Thank you
@drangli
@NicoleKuderer
@connors_md
@RosovskyRachel
@vandy_biostat
& others for v important work to better understand risk of VTE in pts w cancer &COVID-19-so much more to do
@OncoAlert
2
21
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0
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#ESMO2019
#OncoAlert
Dr
@peters_solange
warning about the intra-tumor heterogeneity of
#TMB
:
๐Up to 30%
๐Is blood needed for a reliable & most clinically meaningful TMB?
0
23
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Otis Brawley at
@SWOG
Plenary:
39% Decline in US
#breastcancer
deaths but the decline varies by minority groups and by the state you live in. Mortality disparities only started by 1980s likely d/t screening availabilities. Similar disparities trends for eg
#colorectalcancer
๐
2
14
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@AmandaBinDC
How fantastic & fun to meet several of you at the Tweet-Up!
But where were twitter stars
@PauloBergerot
@montypal
@crisbergerot
@GlopesMd
@DrSGraff
@marklewismd
@chadinabhan
@PatelOncology
@EnriqueSoto8
@oncology_bg
@tmprowell
@tsemiglazovaMD
@weoncologists
6
15
36
Fantastic
#Mentorship
advice that we need more of in our medical training. Our training has become far too dogmatic. Eg, Trainees donโt learn that they need to veer from OS data, if it does not fit with pts goals & needs.
Don't just teach your students to read.
โข Teach them to question what they read, what they study.
โข Teach them to doubt.
โข Teach them to think.
โข Teach them to make mistakes and learn from them.
โข Teach them how to understand something.
โข Teach them how to teach others.
74
5K
11K
1
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1/
#SABCS21
Dr. Safonov identifies germline-somatic
#bcsm
interactions assoc. w therapy resistance:
-gBRCA1 encrichs: somatic TP53
-gBRCA2 enrichs: somatic RB1 monoallelic loss
-RB1 monoallelic loss worse outcome w CDK 4/6
-PIK3CA mutually exclusive w BRCA 1/2
@OncoAlert
0
20
36
Your Moment of Academic Zen ๐
๐
Who can still pay to publish ๐ค
@gary_lyman
@crisbergerot
@PavlosMsaouel
@ADesaiMD
@WilliamDale_MD
@weoncologists
@fumikochino
@jesusanampa
@DrDimitrios
@EllokGr
@oncology_bg
@FaltasLab
@DrJNaidoo
@mshadman
@prat_aleix
@ACortelliniMD
@DJPinato
4
10
36
#OncoAlert
A sighting of a
@ASCO
Fairy has just occurred!!!
@weoncologists
@matteolambe
@PatelOncology
@aftimosp
@tsemiglazovaMD
@DrSGraff
@Alfdoc2
@Tony_Calles
@agrothey
@NarjustDumaMD
@manuelmaiamd
@ChristianRolfo
@TiansterZhang
@StephenVLiu
@guiperini
@prat_aleix
@marklewismd
2
5
35
Thanks so much
#CCC19
Team ๐ or should I rather call you
#CCC19ers
. When you lead the
@ASCO
#ASCO20
news coverge - MAGIC you all โจ๐๐ซ
This was a first for me: starting day2
@ASCO
#ASCO20
, having coffee and then: our study on
@GMA
#CCC19
#Covid19nCancer
@hemoncwarner
@NicoleKuderer
@gary_lyman
@brian_rini
@ADesaiMD
@COVID19nCCC
@corrie_painter
@DrDimpyShah
@PGrivasMDPhD
@myESMO
@TotalHealthConf
@OncoAlert
5
34
126
0
12
36
1/
@OncoAlert
Remarkable
#Cancer
&
#COVID19
Talk
#ESMO20
by Drs. Grivas (Warner, & Khaki) to confirm the main clinical risk factors of our
@TheLancet
paper with greater stats power (N=3,899), f/u data. Now allowing for exploratory lab analysis. Full credit
#CCC19
team
@COVID19nCCC
1
20
35
@kniggem
Smart move Spain to mandate masks in medical facilities - we are in the 2nd biggest wave based on waste-water & 1/3 of population expected to be infected (reviewed by
@EricTopol
)
2
4
36
Chemo-induced peripheral neuropathy (CIPN) in ~47% survivors long-term: Reported significantly more disability,1.8 times fall risk. Increasing symptom severity was linearly associated w functionโฌ๏ธ, disabilityโฌ๏ธ, fall riskโฌ๏ธ (all P < .05). We need to esp discuss w pts if<1-3% OS.
And symptoms significantly worsening after last neurotoxic chemo further adds complexity to being proactive about
#CIPN
#neuropathy
managment and toxicity risk reduction. Nice paper summarizing post treatment issues persisting
1
9
16
0
18
35
@jillfeldman4
@Globeseek
@manjuggm
@zeynep
@AACR
@ASCO
@ivybelkins
@JeamesSailor
1/ Keep it up. Here is some powerful CDC data on immune compromised individuals (all comers, so a mix of serious & moderate) & vacc waning w/ 3 doses is massive by 6 months down to 50% efficacy. My slide from
@CancerCareMASCC
#MASCC22
on COVID19
@MASCC_JSCC
@viviphi_ashbury
1
14
36
@HemOncWomenDocs
@aftimosp
@CharuAggarwalMD
@SuzanneColeMD
@DevikaDasMD
@NarjustDuma
@phase1oncomd
@DrSGraff
@ErikaHamilton9
@DocLHenry
@IshwariaMD
@DrKelseyKlute
@maryam_lustberg
@DrMarkham
@DrLaurenNye
@ninashah33
@rachnatshroff
Can I add some of the most remarkable physician scientists left offโบ๏ธ (and I am sorry to still forget some - please add):
@LeciaSequist
@shilpaonc
@christine_lovly
@rochgerionc
@MaryCushmanMD
@connors_md
@HKlepinMD
@hmcarthur
@OphiraG
@MelissaLoh21
@crisbergerot
@mcquadeMDLAc
11
6
36
@OncoAlert
BREAKING NEWS: 1.
#CCC19
results in
@Lancet
informs global
#COVID19
care. Thanks
@jeremy
and amazing CCC19 team, especially
@brian_rini
@gary_lyman
@DrChoueiri
Dr. Shah
@PGrivasMDPhD
@GlopesMd
@mtmdphd
@peters_solange
@ADesaiMD
@corrie_painter
Dr. Rivera
@arkhaki
1
19
33
@g_mountzios
@ADesaiMD
@maryam_lustberg
@gary_lyman
@curijoey
@OncoAlert
@cczielinski
@jamecancerdoc
@fniainle
@DrJFriedberg
@DJPinato
@kevinpunie
@prat_aleix
@matteolambe
@viviphi_ashbury
@aftimosp
@PamelaKunzMD
@christine_lovly
@MiddeldorpS
@EthicsdoctorP
@NatRevClinOncol
@DianaNrco
@jillfeldman4
@JasmineSukumar
@adrianakahnmd
@DrTJM_MD
@LisaHicksMD
@KSanfilippoMD
@MaryCushmanMD
@sholzberg
@MikkaelSekeres
@kalavisvanathan
Thank you all ๐! Due to popular demand,
@NatRevClinOncol
took the unusual step to make the article available for free download for this 1-month period.
@jillfeldman4
๐ฅณTHANK YOU for your voice & inspiring this pic!
@MassimoDiMaio75
@double_whammied
@recnac1
@SWOGChair
1
11
35
@Lancet
ARTICLE & VISUAL ABSTRACT: 1. RESTULTS of
#CCC19
informs global
#COVID19
care.
@jeremywarner
@ADesaiMD
& amazing CCC19 team, esp
@brian_rini
@gary_lyman
@DrChoueiri
Dr. Shaw
@PGrivasMDPhD
@GlopesMd
@mtmdphd
@peters_solange
@arkhaki
cc:
@ASCO
@SWOG
@ConquerCancerFd
@OncoAlert
BREAKING NEWS: 1.
#CCC19
results in
@Lancet
informs global
#COVID19
care. Thanks
@jeremy
and amazing CCC19 team, especially
@brian_rini
@gary_lyman
@DrChoueiri
Dr. Shah
@PGrivasMDPhD
@GlopesMd
@mtmdphd
@peters_solange
@ADesaiMD
@corrie_painter
Dr. Rivera
@arkhaki
1
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1
21
34
Objective Tox Summary๐ค
Don't Tox also need obj data in summary slides (imagine efficacy summarized as "acceptable" "favorable")? Why not 1 sentence describing %? :
1) Gr 3-5 Tox (w/o Heme)
2) Gr3-5 Tox (w/ Heme)
3) Gr5
4) Any Gr [+/- Hospitalization data]
@paspears88
@ASCO
@VBlinderMD
@CareyAnders1
@UNC_Lineberger
@DukeCancer
@MSKCancerCenter
@ALLIANCE_org
@jillfeldman4
@itsnot_pink
@stage4kelly
@gary_lyman
@LisaHicksMD
@BenChinYee
@jamesyuhemonc
@IBCResearch
@raalbany
@barbarasegarra
@swaggsheila1
@ARosen380
@JaniceTNBCmets
@OncoAlert
@RahulBanerjeeMD
@oncology_bg
@PavlosMsaouel
@AmandaNizamMD
@rachnatshroff
@neerajaiims
@crisbergerot
@ADesaiMD
@NCIDirector
@fumikochino
@prat_aleix
@M_Tagliamento
@g_mountzios
@BianchiniGP
@curijoey
@Icro_Meattini
@NeliMUlrich
@stolaney1
@TomasPascualMD
@FrancescoSche20
@CharuAggarwalMD
@VeredStearns
@awolff
@AngieDemichele
@MyriamChalabi
@kevinpunie
@CarmenCalfa
๐ซ If only 1 thing you take home beyond
#asco23
efficacy data make it our poster๐why not to impose our judgem call re
#Tox
on pts
๐ซOnly patients can decide what
#Tox
are truly tolerable, manageable,etc longterm
โจ
#ToxTransparency
Team ๐โจ
@OncoAlert
0
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35
6
13
36
๐๐๐A med centers loses 2 young physicians to
#COVID
-19. When does this become negligence if profit w no tests & gear? All need to pause & consider our responsibility to uphold the integrity of our med institutions, the team, our national med future.
@senpattykuderer
@OncoAlert
0
5
33
๐ฎ๐น Italy this
@Forbes
article is for you ๐ฎ๐น:
โThe generosity of our Italian colleagues [physicians], in particular, and subsequently from other countries to share their experiences and warn us..."
Article by
@MKnoll_MD
@curijoey
@APassaroMD
@APassaroMD
@AnnaFalanga19
@ICTHIC
Congrats to everyone at
#oncoalert
Cancer And Coronavirus via
@forbes
The global medical community and even beyond coming together more closely represents already a remarkable positive effect arising from this harrowing crisisโ
@nicolekuderer
@PGrivasMDPhD
1
14
22
1
18
35
4/ European Travel
#esmo22
On the way to beautiful Italy โจ๐ฎ๐นโจ
If you ever wanted to drive through Southern Germany, Black Forest region, here you go โบ๏ธ.
โฆ
@gary_lyman
โฉ
6
2
34
@paspears88
@ASCO
@VBlinderMD
@CareyAnders1
@UNC_Lineberger
@DukeCancer
@MSKCancerCenter
@ALLIANCE_org
@jillfeldman4
@itsnot_pink
@stage4kelly
@gary_lyman
@LisaHicksMD
@BenChinYee
@jamesyuhemonc
@IBCResearch
@raalbany
@barbarasegarra
@swaggsheila1
@ARosen380
@JaniceTNBCmets
@OncoAlert
@RahulBanerjeeMD
@oncology_bg
@PavlosMsaouel
@AmandaNizamMD
@rachnatshroff
@neerajaiims
@crisbergerot
@ADesaiMD
@NCIDirector
@fumikochino
@prat_aleix
@M_Tagliamento
@g_mountzios
@BianchiniGP
@curijoey
@Icro_Meattini
@NeliMUlrich
@stolaney1
@TomasPascualMD
@FrancescoSche20
@CharuAggarwalMD
@VeredStearns
@awolff
@AngieDemichele
@MyriamChalabi
@kevinpunie
@CarmenCalfa
๐ซ If only 1 thing you take home beyond
#asco23
efficacy data make it our poster๐why not to impose our judgem call re
#Tox
on pts
๐ซOnly patients can decide what
#Tox
are truly tolerable, manageable,etc longterm
โจ
#ToxTransparency
Team ๐โจ
@OncoAlert
Come & Visit our
#toxtransparency
team's ๐๐ poster assessing objective & subjective toxicity minimization in
@ASCO
abstracts
Care Delivery & Policy
Mon 1:15 PM - 4:15 PM
Hall A
Board
#161
Co-First
@jamesyuhemonc
@DrTJM_MD
Co-Last
@LisaHicksMD
@NicoleKuderer
1
7
13
0
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@OncoAlert
๐จ๐Interested in Liquid Biopsies๐๐จ
FREE EDUCATIONAL VIRTUAL CONFERENCE by
@isliquidbiopsy
. Join Us Oct. 22.
Amazing Program
@ChristianRolfo
@drgandara
@MCristofanill
@UmbertoMalapel1
@ElJanLe
@MJOSESERRANO19
and many more
@SWOG
@SupportingSWOG
@fredhutch
@eaonc
3
28
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๐นHappy Birthday My Amazing Husband
๐นHappy 20th Anniversary Year
cc: โฆ
@gary_lyman
โฉ
7
2
34
Perfect ending to the
@ASCO
adjuvant
#breastcancer
sessions
#ASCO22
: Dr. Laura Esserman quote:
"Please, if you have biospecimens, interrogate the biology, especially when so much
#toxicity
is on the line." (speaking also of 5 yrs of ovarian suppression)
@OncoAlert
@gary_lyman
0
8
34
I am coming out of the closet: I have never seen an episode of โGame of Thronesโ. Now it even gets covered on 60-Minutes. Should I change the trend & start watching - what do you think?
16
1
32
Dr. Eric P. Winer on pCR: "The unfortunate part of all of this is that most of our therapies seem to deepen the response, meaning we're often only improving upon a good response and not converting someone who wouldn't have responded."
via
@TargetedOnc
1
8
33
From the bottom of my familyโs โค๏ธโค๏ธโค๏ธ including & especially my parentsโ โ thank you for your bravery & service โ this will always be appreciated during my lifetime โค๏ธโค๏ธโค๏ธ:
The world continues to be very much in need of a strong & powerful USA!!!
2
15
33
1
1
33
1/
#OncoAlert
Congrats for herculean effort to broaden trial
#eligibilities
by
@ASCO
and
@CancerResrch
(Friends of Cancer Research) & key individuals involved! Key for pt trial access. Big Kudos also to
@FDAOncology
for issuing draft guidance based on below
@JCO_ASCO
publiations:
Broadening Eligibility Criteria to Make Clinical Trials More Representative Eligibility criteria are necessary...
0
4
19
2
17
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1/
@OncoAlert
#ASCO22
โจPresidential Addressโจ
@ASCOPres
"High-quality, equitable Cancer Care World-wide.
@ASCO
joint statement with
@WHO
& ASCO initiatives"
#ASCO22
'Bout Last Night:
๐ค
#IRL
#MedTwitter
friends and mentors!
@AnaVManana
@oncology_bg
@GlopesMd
@marklewismd
@JackWestMD
๐
@ASCO
@ConquerCancerFd
ceremony for 2021
#YIA
and cheered for
@Ryan_M_Carr
@Jenny_J_Li
@MayoHemeOnc
@AnaVManana
๐๐ป
@cancerGRACE
for ๐with
@esinghimd
3
7
40
1
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33
Congrats
@TDorffOnc
for being a Plenary speaker
#ASCO19
! Nice to have great female representation againโบ๏ธ๐บ!
cc:
@DrSGraff
@DrMarkham
@NarjustDumaMD
@TiansterZhang
@shilpaonc
@IshwariaMD
@AshleySumrallMD
@phase1oncomd
@christine_lovly
@MelissaLoh21
@maryam_lustberg
@crisbergerot
@montypal
@ASCO
@cityofhope
@ANZUPtrials
@Prof_IanD
@DrHWoo
@Uromigos
@PCF_Science
@PCFnews
@SWOG
@AzadOncology
@neerajaiims
@WilliamDale_MD
@PauloBergerot
Thank you for the kind words! Iโm working hard to make it a valuable presentation. Very excited to learn from all the speakers at
#ASCO19
and catch up with everyone!
0
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0
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@marklewismd
Our profession needs to speak up. It is our responsibility to patients. As gov is needed to provide care for the needy, the med profession is partly responsible, if the gov does not support care that is equitable care.
0
7
31
In Honor of Holocaust Memorial Day: My favorite memorial site across German Parliament as a daily reminder to never again
- an extreme narcissist leader (aka no ethical boundaries) even if policies bring great economy
- switch off media as lying press
- control justice department
1
16
33