tal.iram
@iram_tal
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#newPI #neuroscience lab @WeizmannScience starting February 2024. we study mechanisms of oligodendrocyte and white matter aging and rejuvenation.
Joined September 2018
סטודנטים/יות ופוסט-דוקים/יות, ההרשמה לכנס בנוירוביולוגיה תאית ומולקולרית תיסגר בעוד שלושה ימים (3 בנובמבר)! יש עדיין סלוטים להרצאות ופוסטרים, אז מהרו להירשם (זה בחינם) ולהגיש תקציר ( https://t.co/sBSexs1jk3). מחכים לראותכם במכון ויצמן ב 17 בנובמבר!
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🚨📢 Excited to announce our new paper in Science Advances! We’ve uncovered how Shank3 mutations affect myelination in an autism mouse model and human iPSC-derived OPCs. 🧠💡 Check it out! https://t.co/0uVHAKHVJS
science.org
Shank3 mutation disrupts glutamate signaling and myelination in ASD mouse models and human iPSCs.
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A year in ongoing trauma is difficult to explain, but it’s difficult for me to concentrate on anything else. Sorry for the long long post. This year, I’ve dealt with traumas on multiple levels.
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It has been one year since the unthinkably evil events of Oct. 7 2023. My heart, still in pieces, is with those mourning their loved ones and those still enduring unimaginable horrors at the hands of the terrorists who kidnapped them. #LetThemGoNow
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Great work by @sophiesiems @SGargareta @vinydg Hauke Werner etc. investigating CNS myelin proteomic heterogeneity across different ages, sex, and major regions in vivo 🐚👏 https://t.co/WOdERu2r0a
onlinelibrary.wiley.com
We analyze myelin purified from mouse CNS tissue by quantitative proteomics. The protein composition of myelin matures between P18 and P75. Regional heterogeneity but no sex-dependent divergence of...
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Preprint is finally out! Mapping whole brain oligo-myelin patterns across individual mice, sex, strain, aging, and injury ( https://t.co/AJ8ofQTcQx) Check out some cool videos as well! https://t.co/9WqpdvWvWG And play around with the beautiful raw data! https://t.co/IX8T95MNkE
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What an amazing way to start the lab! We cant wait to uncover more mechanisms of oligodendrocyte and myelin plasticity and learn how it impacts cognitive aging. More details in our website - https://t.co/vNQwHeXuDZ DM or email me if you are interested to join the team! #ERCStG
Congratulations to our 8 talented researchers who were granted the 2024 @ERC_Research Starting Grants - Drs. Alexandra Tayar, Eliran Subag, Mark Shusterman, Ranit Kedmi, Samer Gnaim, Tal Iram, Yuval Ronen and Tslil Ast. We are very proud of you! #ERCStG
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Out now! “Schwann cell-secreted PGE2 promotes sensory neuron excitability during development.” Published online today @CellCellPress.
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Oligodendrocytes produce amyloid-β in AD mice and reveal a threshold for plaque deposition. Great study by Andrew Sasmita, Constanze Depp et al.
nature.com
Nature Neuroscience - In Alzheimer’s disease, neurons are considered the sole source of amyloid-β (Aβ) peptides that form plaques. Here the authors show that oligodendrocytes, the...
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Excited to share our recent work in @cellcellpress: Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain: Cell https://t.co/7RkpnE7TXT
@stevens1lab 1/n
cell.com
The microglial-secreted complement protein C1q is internalized by neurons in an age-dependent manner, undergoes RNA-mediated interactions with neuronal ribonucleoprotein complexes, and alters...
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Out in @Nature today - the research that has been such a huge part of my life over these past few years. Myelin plasticity is a critical component of neural circuit modifications opioids evoke to drive reward learning.
Maladaptive myelin changes on dopaminergic axons after morphine use modify reward circuitry to give rise to drug-seeking behavior in mice. Final version of study led by @BelginYalcin_ out today! #OpiateCrisis
https://t.co/G882iQo9c4
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Please retweet! TWO open position for PhD candidates at my lab and Thomas Boulin's lab @Boulin_Lab, within the framework of the European Training Network: Molecular plasticity of neurons during C. elegans lifespan. for more info- https://t.co/0aeo5CIU0T
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@ImmunityCP Our paper on using the novel Clec7a-CreER mouse to label, track and manipulate PAM/DAM microglial states is finally out in @ImmunityCP Congrats to the first author Kia Barclay @optic_kiasm Many thanks to the collaborators from @TheColonnaLab @kipnislab @yu_guoqiang @SaligramaLab
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Once thought to be a static structure, mature myelin made by oligodendrocytes has been full of surprises. Check out our new review on the topic!
Extremely excited to share our review on mature myelin dynamics out today! @EthanHughesLab and I discuss myelin remodeling and turnover, mechanisms and functional implications. I hope folks will enjoy diving into this fascinating emerging field with us! https://t.co/kb6RWAWFjM
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Three-photon microscopy for long-term in vivo three-photon imaging of the entire cortical column and subcortical white matter in adult mice reveals region-specific differences in healthy and regenerative #oligodendrocyte formation @EthanHughesLab et al. https://t.co/ltu37T58H7
nature.com
Nature Neuroscience - Brain region-specific oligodendrocyte population dynamics are unclear. Here the authors implement long-term in vivo three-photon imaging to determine those dynamics in the...
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Interested in research on aging and neurodegeneration? @wysscoray lab has 2 LSRP positions open! If you're interested and meet the requirements in the posting, please apply and reach out directly to me or Ian Guldner! See the application link here.
careersearch.stanford.edu
Stanford University is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research...
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Brain signaling depends on myelin insulation — which declines with age and in disorders like MS. New research led by @tal_iram and Miguel Garcia in @ZucheroLab finds a driver of myelin formation that could lead to new therapies to maintain brain health.
neuroscience.stanford.edu
New research supported by Wu Tsai Neurosciences Institute could lead to novel treatments for demyelinating disorders such as multiple sclerosis.
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Congrats to the team again, and thanks to Dr. Andrew Olson for imaging this beautiful #oligodendrocyte #cytoskeleton featured on the cover
In this issue: preserved magnetism from the early solar nebula, group formations among solitary animals, and expansions and recessions of human populations. https://t.co/A1A5Dx9C4f
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What Alzheimer noted as fat saccules in glia may have been lipid droplets. They can be induced by Abeta in microglia leading them to release factors that damage neurons. ApoE4 makes things worse https://t.co/KrOWS2RNZx. Congrats @Michael_S_Haney @robipalo and fantastic team
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We have liftoff! 🚀 Excited to share our new work revealing an essential role of the transcription factor SRF in @myelination, out today @PNASNews. Led by the amazing @iram_tal and Miguel Garcia in collaboration with @fabiankern13, @wysscoray, and their labs.
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