Ethan Hughes
@EthanHughesLab
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neuron-glial interactions, oligodendrocyte lineage, myelin, multi-photon microscopy @CUMedicalSchool
Denver, CO USA
Joined October 2018
Glad to share our published version: “ Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms”, led by @AksheevB
https://t.co/V09WCcX2A8
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Driving CNS myelination with an approved drug. Fantastic collaboration with Hannelore Ehrenreich and her team at @mpi_nat
nature.com
Nature Communications - Oligodendrocytes are critical for brain myelination and repair. Here, the authors show that erythropoietin enhances oligodendrocyte lineage progression, promoting...
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Excited to introduce four new mouse lines described in our recent study @YiheZhang97 (soon available from JAX), including two lines for studying TFEB in broader contexts (TFEB 6xMyc, JAX#041044; Rosa26-TFEBS141A;S210A-Halo, JAX#041043) and two new KI lines for myelinating OLs.
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1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too
biorxiv.org
Understanding biological systems requires observing features and processes across vast spatial and temporal scales, spanning nanometers to centimeters and milliseconds to days, often using multiple...
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You can support the next generation of myelin scientists by funding the Myelin Gordon Research Seminar: https://t.co/XtaQAwtQmq.
@ubhjkri @MS_Focus @mssociety @NeuroForuMS @SfNtweets @GlialInitiative
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Excited to finally have this published! Out today in @NatureComms, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. https://t.co/g4FkMKGckJ 1/3
nature.com
Nature Communications - The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but...
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Extremely happy to share our manuscript jointly authored by me and the amazing @LindsayOsso ! An awesome collaboration between the @EthanHughesLab , @denmanlab and Autobahn Therapeutics https://t.co/TNIKY3O6dz 🧵
nature.com
Nature Communications - Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination...
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Excited to share our work published this week! Led by myself and world class co-first @gdfnunes working in the @EthanHughesLab in collaboration with Dan Denman: https://t.co/HH9RKGY4ar. A short 🧵
nature.com
Nature Communications - Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination...
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New paper out from the lab! Led by @gdfnunes and @LindsayOsso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠 https://t.co/9HbBgwyKit
nature.com
Nature Communications - Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination...
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Our 7-year journey on glia-like taste cells is finally published in @CellCellPress! We report how the glia-like cells shape sweet adaptation on the tongue. Huge thanks to our lab members, especially Ghayeon & Geehyun, and collaborators @yulonglilab.
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New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions. https://t.co/qGx23d7Dxp
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My first-author paper is out today @NatureComms ! We investigated how oligodendrocytes produce myelin. Using volume EM, we characterized oligodendroglial ER (magenta) in developing myelin and explored nonvesicular lipid transport involved. #lipidtime
https://t.co/COW6ZjIQk7 (1/n)
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Cool! Learning-associated astrocyte ensembles regulate memory recall https://t.co/YgC0BBaKju
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Our work with @schirmerlab in multiple sclerosis (MS) is out today in @NatureNeuro. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️ https://t.co/j6LIwv4IgU
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Agreed! That's why I wrote ggpubfigs, a ggplot2 extension that *only colorblind-friendly color palettes. Easily make your figures colorblind-friendly with ggpubfigs! https://t.co/frQgsl7zjP
A reminder that your search committee chair, grant proposal reviewers, and manuscript reviewers might be among the 1/12 XY or 1/200 XX who can’t see what you think is obvious in your figures because they have a color vision deficiency. Adobe tools, many papers on the topic, etc.
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🚨 Cues of trained immunity in macrophages of Multiple Sclerosis patients... Curious to know more? 🔍 Dive into our latest paper showcasing the fantastic work by Jennifer Fransson! 🧾✨ #MultipleSclerosis #TrainedImmunity #OpenAcess
@InstitutCerveau
https://t.co/3AgRG21wgC
neurology.org
Background and ObjectivesIn multiple sclerosis (MS), immune cells invade the CNS and destroy myelin. Macrophages contribute to demyelination and myelin repair, and their role in each process depends...
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My second manuscript from graduate school is now on bioRxiv! We generated a comprehensive scRNA-seq dataset of mouse OPCs from young adult to aged animals with the hope of providing a reference dataset for everyone to dig into!
Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan https://t.co/DCckLHIm4q
#biorxiv_neursci
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https://t.co/C2wLRnCv0m I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are:
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Important work from Fraser Sim's lab-keep in mind for MS: "Clemastine Induces Oligodendrocyte Progenitor Pool Exhaustion and Senescence in the Context of Chronic Demyelination in a Rabbit Model"
onlinelibrary.wiley.com
Objectives Clemastine has emerged as a promising therapy for the restoration of neurologic function in patients with multiple sclerosis (MS). However, clemastine and other agents with prodifferenti...
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