Kipnis Lab
@kipnislab
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We like all things #neuroimmune!
St Louis, MO
Joined August 2019
@kipnislab we are looking forward to your presentation at #TargetAD25 in Crete next May🇬🇷☀️Registration & Talk Submission is now OPEN so please RT to let your followers know! Find out more: https://t.co/UnjcdFajPX
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New @Nature An unanticipated discovery: the brain suppresses the immune response by producing autoimmune "guardian peptides" that block neuroinflammation, which may be especially important in neurodegenerative diseases https://t.co/wbdi7kxHCQ Important work by @jonykipnis
nature.com
Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.
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How is the #CNS protected from the immune system? @MitchKim_MW and a team in the @KipnisLab found that regulatory self-peptides bind to MCH II molecules at the central nervous system border. @Nature paper: https://t.co/POjXUnpJax Discussion: https://t.co/y9iZAmjy17
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Excited to share a new work from @kipnislab by amazing Wenqing Gao (twitter-less) on developing engineered T cell therapy for CNS injury ||
nature.com
Nature - This study presents a new T cell therapy targeting spinal cord injury, providing a potential new approach for injured CNS.
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We are very proud of @DuSiling for wining the best poster prize at @WashUdbb @WUSTLImmuno retreat! Congrats, Siling! The story is amazing and you are very deserving of this recognition!
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🧵 Excited to share my first preprint from my PhD @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴 https://t.co/czMqzFmKXz
biorxiv.org
Microglia are thought to originate exclusively from primitive macrophage progenitors in the yolk sac (YS) and to persist throughout life without much contribution from definitive hematopoiesis. Here,...
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Our Spotlight on the groundbreaking work of @lcdsmyth, @jonykipnis, @kipnislab and colleagues is out in @TrendsImmuno. 🧠💡 Thanks to #JavierMaríaPeraltaRamos and #MichalSchwartz.
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Excited that this conference is coming to us! Amazing lineup of speakers! Please register and RT!
Excited to co-host another amazing conference #ReThinkNeuroimmunology together with @IdoAmitLab. This time we are hosting @WUSTLmed @WUSTL. Registration site is now open. Please register asap. Number of seats is limited. https://t.co/K6zsSRp6We
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In 1992 @SciAM article, Carla Shatz summarized Hebb’s theory as “Neurons that fire together wire together”. Today, inspired by Carla's phrase, we bring you “Neurons that fire together shower together”. Why do we sleep? Why to we emit waves? @neurobenjamin attempted to answer
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WashU Medicine researchers are uncovering sleep’s role in maintaining brain health. Rhythmic waves associated with restful sleep help to propel waste and toxins away from the brain. Learn more:
medicine.washu.edu
Findings could lead to new approaches for Alzheimer’s, other neurological conditions
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Excited to share our work published today. We identified that neurons are the master organizers for brain fluid perfusion and waste clearance. Inspired by Hebbian rule and Carla Shatz’s phrase, we summarize it as 'neurons fire together shower together'. https://t.co/Yc7W2RKGhk
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Nature research paper: Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
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Active neurons can stimulate the clearance of their own metabolic waste by driving changes to ion gradients in the surrounding fluid and by promoting the pulsation of nearby blood vessels
nature.com
Nature - Neurons stimulate the brain's waste disposal system.
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This paper from @jonykipnis lab is incredible. Striking results that have updated how I think about what neural activity in the brain is actually doing - especially during sleep or anesthesia. Elegant approaches and easy-to-follow and compelling writing. https://t.co/zIAHvnWkft
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Absolutely honored to join the CZI community and thrilled to embark on this with the one and only @jonykipnis. This joint effort is set to push the boundaries of neuroscience and advance brain health. Grateful and excited for what's ahead! #neuroimmunology #makingADifference
We’re excited to support 64 interdisciplinary teams that are taking innovative approaches to study fundamental #neuroscience + neurodegenerative diseases. Read more about our second cycle of @ChanZuckerberg’s Neuroscience Collaborative Pairs Pilot Projects
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The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases https://t.co/nPlehXgGBg
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Thank you to @matrongolo, @d0ctorphil, Aditya Jain, Akash Reddy, Gaetan Barbet, Young-Kwon Hong, Junbing Wu, and rest of the team for their hard work + dedication to this study🙏👏 this is a very exciting field for those interested in opportunities (DM me), and much more to come!
Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice: https://t.co/DKrIiDhSK4
@tischfield @Rutgers_NJMS
#Neuroscience #VascularBiology
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We're excited to share these tools with the scientific community to enable a more precise dissection of the functions of different CNS fibroblast types. Dpp4-CreERT2 targets arachnoid barrier cells, while Slc47a1-CreERT2 targets dural border cells.
A delivery of @lcdsmyth’s strains from his recent paper to Jax is being finalized. We already have the strain numbers and I hope they will soon be available to the scientific community to explore the menigeal (and other) fibroblasts! Stock No. 039217 Dpp4-CreERT2 Stock No.
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Super excited for this award for our collaborative project with @felipe_pinh0. But even more excited to join this exceptional group of scientists and can't wait for the in-person meeting to meet everyone and to brainstorm!
We’re excited to support 64 interdisciplinary teams that are taking innovative approaches to study fundamental #neuroscience + neurodegenerative diseases. Read more about our second cycle of @ChanZuckerberg’s Neuroscience Collaborative Pairs Pilot Projects
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How does fluid waste leave the brain? A new study by #WashUMed uncovers the passageways that carry waste away from the brain, offering potential therapeutic targets for neurodegenerative diseases:
medicine.washu.edu
Discovered route serves as passageway to clear fluid waste from brain
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