Ci Ji Lim
@cijilim
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Migrated to Bluesky: @cijilim.bsky.social
Madison, WI
Joined October 2018
Our paper in Science is out! @Sour_Agrawal, @xiuhua_linwisc, @viveksusvirkar, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation.
science.org
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical...
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On a gruelling hunt for rare associated molecules in your #cryoEM particle stack and not sure where to look? Discover practical tips and tricks in our new case study using #CryoSPARC v4.7.1 where we find and refine a low-population interaction partner! https://t.co/O38hK0KmjZ
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We also like to point out a similar work published at the same time by researchers at Gilead Sciences 🤝💪:
nature.com
Nature Microbiology - The cryo-EM structure of the herpes simplex virus helicase–primase (HP) complex informs about the mechanism of action of HP inhibitors pritelivir and amenamevir, which...
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New work from Tahirov x Lim collaboration! @QixiangHe from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development. https://t.co/WSvcRpPn9E
@unmc @UWBiochem
science.org
Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.
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2. Finding a protein critical for telomere maintenance (RPA) @ScienceMagazine #AlphaFold
https://t.co/MuptUQi0Xw
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New findings from @cijilim in @UWBiochem identify a protein as essential to maintaining the end-caps on chromosomes — helping doctors around the world connect a genetic mutation to their patients' illnesses. https://t.co/m6btvt1g3K
biochem.wisc.edu
Researchers in the Lim Lab reveal that dysfunction in a protein essential to maintaining stability in our chromosomes may be responsible for serious diseases.
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📢 We’re hiring! @StanfordUChem is now accepting applications for a Junior Faculty Position in Chemistry (open area), with the appointment set to begin on September 1, 2026. Learn more and apply here: https://t.co/H43xkCJhEe
#FacultyJobs #AcademicJobs #Hiring
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Join us on Monday September 8 for the first seminar of the Fall 2025 Biochemistry Colloquium series! Arthur Edison @universityofga will be talking about annotation and quantification in #NMR metabolomics. More info:
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Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal : https://t.co/YmsR18WcRJ
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Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳 https://t.co/5SaPnwQ4zf Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
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Promiscuous membrane transporters move everything—but how? In this perspective, we make a case for high-throughput genetic screens as a key to decoding polyspecificity, enabling drug design, and advancing synthetic biology. https://t.co/pGT2GO3hHW
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Congratulations to Professor Katherine Henzler-Wildman, who was elected a fellow of the American Association for the Advancement of Science!
biochem.wisc.edu
Henzler-Wildman is known for her exploration of the dynamics, mechanisms, and functions of transport proteins that control movement of molecules across cell membranes.
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Apply by ✨Dec. 1st✨ to share your science, network with peers + potential postdoc mentors, and explore the beautiful @CUAnschutz campus! #CUPEAKS
🧑‍🔬Are you thinking of doing a PostDoc? We would LOVE to “CU” here!🎉 Come to PEAKS, our Postdoc Recruitment event taking place April 7-8, 2025! 🧪 Present your Thesis work 🧑‍🏫 Meet our Faculty 🏫 Campus Tours 🤝 Networking Opportunities 💬 Engage with the CU Anschutz Community
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In response to COVID-19, researchers examined SARS-CoV-2 structures to identify possible treatments. Now, the @RKirchdoerfer Lab is comparing what we know about different coronaviruses to explore whether therapeutics might work across this virus family:
biochem.wisc.edu
Researchers in the Kirchdoerfer Lab are identifying which structures are conserved (and which aren't) across coronaviruses.
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The Steenbock Seminars in the Biochemistry Colloquium fall 2024 series will be held on Nov. 18 & 19. Join us as Jeff Gordson shares his foundational work in defining the role of the gut microbiome in health and nutrition. More info: https://t.co/8QHGod9ss2
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Science friends heading to the Other Place 🌌—let’s not lose each other in the void. Over the next few weeks, I'll try to put together some science "starter packs" of who to follow. Fill out this form to be included. https://t.co/gNIF2oGF4E Share widely ❤️
docs.google.com
Join the science community! Select your field of interest, add your handle, and tell us a bit about your work. This form does not automatically add you to a group but expresses your interest in being...
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Proud of the Simcox lab members @hunger4science @LainyVonBank @_JessDavidson @JerichaMill for being featured for their booth at the Science on the Square! Great work raising enthusiasm for science research in the next generations. https://t.co/V0vEHyD9EO
badgerherald.com
In its seventh year of action, Science on the Square invited scientists and organizations to display their work in fun and interactive ways Oct. 17. State Street, Madison’s central hub, was lined...
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Professor Rick Amasino is leading an international team seeking to enhance plants’ abilities to mine nickel from naturally enriched soils. Learn about this DOE @ARPAE-funded research, which is unleashing plants' potential to enhance clean energy options:
biochem.wisc.edu
With funding from the Department of Energy, Rick Amasino is leading an international team seeking to enhance plants’ abilities to mine nickel from naturally enriched soils.
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A one day meeting on Friday 6th December covering all aspects (and scales) of Structural Biology. Lots of talk slots to be selected from abstracts. Deadline for abstracts is this Friday (15th Nov). https://t.co/LiLgzEM7aU
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Excited to host Greg’s Hirschfelder Visitor seminar this coming week! Join us for his talk at 11am on Tuesday in the Seminar Hall of the Chemistry Dept! @drGregBowman
Our next Hirschfelder Visitor is Prof. Greg Bowman @drGregBowman from @Penn hosted by Xuhui Huang @XuhuiHuangChem. He will speak about cryptic pockets and allostery at 11 am, Nov 12, Tue! List of past TCI Hirschfelder Visitors: https://t.co/McHnuhrvXV
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