Carter Lab
@Carter_Lab
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Joined August 2015
Check out this stunning animation by @janetiwasa (in collaboration with @SamReckPeterson), showcasing our model of how various components come together to form active dynein complexes capable of transporting cellular cargo.
Our work on how the lysosomal adaptor JIP3, and regulator LIS1 activate the dynein motor protein is now out in @ScienceMagazine ! Many thanks to our reviewers and editor for their valuable input.
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A one day meeting on Friday 6th December covering all aspects (and scales) of Structural Biology. Lots of talk slots to be selected from abstracts. Deadline for abstracts is this Friday (15th Nov).
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Today at #journalclub we looked at the structure of tubulin acetyletransferase bound to the microtubule lumen
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A fantastic paper describing a novel mechanism of selective inner mitochondrial membrane removal guided by lysosomal-mitochondrial communication (Dr. Akriti Prashar, @NicolaJGI) #JournalClub
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RT @samlacey745: Our paper looking at the structure of retrograde IFT trains is out now! Have a look at the link, or see some of the headli….
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Today at #journalclub we learned how bacteria protect themselves against phage infection by conjugating ubiquitin-like proteins to the phage tails 🤯
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My first PhD student, Emma Hanford (nee Gleave), made some cysteine-lite dynein constructs in 2013. 11 years later, thanks to MinFlux, Joseph Slivka and @Yildiz_Lab they have been used in a nice biorxiv paper.
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Today in Journal Club - Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies
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RT @diorge_souza: We're thrilled to share our new preprint: "Evolutionarily Conserved Principles of ESCRT-III-Mediated Membrane Remodeling….
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Today in #journalclub, we discussed the fascinating molecular infrastructure of glutamatergic synapses
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Great work from the Dodding and Woolfson labs showing how a designed peptide can activate kinesin in vitro and in cells #journalclub.
Great to see our work on manipulating kinesin-1 activity using protein design led by @jessica_a_cross in print. In collaboration with @WoolfsonLab. @BristolBiochem @BristolChem @BrisBioDesign .
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Very interesting work showing that local translation on axonal ER tubules is mediated by RRBP1 #JournalClub.
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RT @i_harasimov: Excited to share our latest study! We discovered that maintaining mammalian oocytes involves extraordinary protein longevi….
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In yesterday's #journalclub, we had a look at the interesting mechanism by which the UNC-104 motor (Kinesin-3 KIF1A homologue in C. elegans) is stabilised on Rab-3-containing synaptic vesicles - by Bhan and colleagues.
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Today in #Journalclub we looked at how Alphafold2 models can guide prospective ligand discovery. A nice study combing in-silico docking and cryo-EM out now in @ScienceMagazine .
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Great work from the McKenney lab reconstituting the KASH protein Nesprin-2 bridging actin to kinesin/MTs #journalclub
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Today in #journalclub we delved into the structure of the Flotillin complex. Fascinating insights into how this cage complex could induce membrane curvature and provide a sealed diffusion barrier, connecting membrane systems.
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Outstanding work from the Zhang lab on helping clarify dynein's complicated mechanochemical cycle #journalclub
How does dynein cycle its conformations and takes one step forward along the MT? .Check out our exciting new results unveiling the atomic details of the conformational space of Reactive Full-length Human Dynein-1, on and off microtubules:
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The GRC conference on Cytoskeletal Motors is soon, spread the word! Check the lineup below and registration details.
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This was a fantastic collaboration with @JSalje and her twitterless postdocs Kittirat and Chitrasak. Orientia is a truly fascinating pathogen and there is so much more to explore. For example, why does it like to move to the perinucleus? (6/6).
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