1/n Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge. Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. https://t.co/05TOm2FXaC

New work from Tahirov x Lim collaboration! @QixiangHe from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development. https://t.co/WSvcRpPn9E @unmc @UWBiochem

Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. https://t.co/OlU6HOLQfK

New pre-print(s) from the Sternberg Lab in collaboration with @LeifuChangLab! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: https://t.co/4eCvIxzGD4

The sequel to our DRT2 story is here, and this one is once again full of surprises! This time around, the @SternbergLab teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: https://t.co/oljHRA7Vj1

Curious about FM transmission of biological data? Check out our new preprint: "Genetically encoded protein oscillators for FM streaming of single-cell data." A game-changing toolkit to create cellular radios that communicate directly with cell biology. https://t.co/IYVW0YTlEb

Great #cryoET #cryoFIB #sub-tomo workshop ⁦⁦@UWBiochem⁩ #cryoEM centers! New #teamtomo trainees ready, set, go! Thanks speakers, trainers, staff, sponsors. ⁦@NIH_CommonFund⁩ #cryoEM ⁦@delmicbv⁩ ⁦@SubangstromLLC⁩ @LeicaMicro⁩ ⁦@thermosciEMSpec⁩

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” https://t.co/hGFSdFMq7E #Lasker2024 #LaskerLaureate

1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

1/7 Our latest preprint is out! 🚨 @Sour_Agrawal , @xiuhua_linwisc , @viveksusvirkar et al. discover human RPA is a critical telomerase processivity factor essential for telomere maintenance. This reshapes our understanding of human telomerase regulation. https://t.co/HJkap1APl4

I'm thrilled to share my first project in @CellRaiser_ 🤩we found that MTs-assembly can be tuned at both MTBD and condensates. This project highlights my past(microtubule), present(SynBio), and future(LLPS): https://t.co/Hx2yZY8V8m

Excited to receive the fellowship from @UWMadisonCALS! Grateful for the support from @cijilim, @UWBiochem and @UWMadBiophysics!😁🙏

Huge congratulations to Qixiang for winning the highest recognition for graduate students. 🎉🚀 Thank you, Renata for writing up this award! 🙏🏻

Congratulations to Qixiang He (@QixiangHe), who was awarded a Louis and Elsa Thomsen Wisconsin Distinguished Graduate Fellowship! https://t.co/1D38TllEMF @cijilim @UWMadisonCALS @UWMadBiophysics

37 scientists will join the 2024 class of @pewtrusts scholars and fellows, and we are proud to announce Professor Ci Ji Lim (@cijilim) is one of them!

Our first paper is out in @CellCellPress! Led by @born2raisecell, we present a programmable reaction-diffusion system that generates synthetic protein waves, oscillations, and patterns for spatiotemporal circuit design and FM data-encoding in human cells. https://t.co/lNRtRdJAxx

Online now - the Review "Models for human telomere C-strand fill-in by CST–Polα-primase" from @QixiangHe and @cijilim. #telomeremaintenance #CStrandFillIn #CST #DNAsynthesis #primersynthesis Read it here 👉 https://t.co/PjJ1qh6nS5

Our biggest discovery yet (IMO). The 5’ ends of our chromosomes are capped(!) by #telomeric protein POT1 to prevent their misrecognition as broken DNA. Brilliant work of Drs. Valerie Tesmer and Kirsten Brenner @ScienceMagazine https://t.co/ozZIuZrTsh 1/n

Happy to share our review of the human telomere C-strand fill-in mechanism. Appreciate the opportunity to be involved in the process and learn a lot from @cijilim and the revision.