Davide Castaldi
@castaldi_davide
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PhD Student in Computational Biology. Geek. Biker.
Milan, Lombardy
Joined November 2018
NewPreprint alert 📢 Thrilled to share our new work: A molecular cell atlas of endocrine signalling in human neural organoids 📄 Paper: [ https://t.co/vFMmV1dn2h] 💻 Github: [ https://t.co/co5XF1z2q9] Eager to know more? 👉🧵 1/
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What a beautiful home for our multiplexed organoids! Kudos to all the members of the @gtesta72 lab who contributed to the project. And a big shoutout to Philipp Dexheimer for this absolute piece of art!🎨
Our February issue is live! 🎉 https://t.co/RQsDcOymUt On the cover, a human brain emerges from multiple stem cell lineages, representing a method to link genetic variation to neurodevelopmental trajectories. Paper here: https://t.co/uzdlxV5wfk Image by Philipp Dexheimer.
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📢 Paper alert! Our paper on cortical brain organoids multiplexing is out @naturemethods. https://t.co/5OzaItMkS2 Together with the Research Briefing https://t.co/cjeZGfqn9E /1
nature.com
Nature Methods - This paper develops two approaches for multiplexing cortical organoids and SCanSNP, a method for deconvolving cell identities, to trace neurodevelopmental trajectories at scale.
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Sweet conclusion to 2024! It was a challenging but worthwhile journey in the @gtesta72 lab. Special thanks (and a big hug) to @NicoloCaporale, @RigoliMt @CarloEmanueleV1 and @v_ale_nti for laying this new tile together in the brain organoids mosaic :) https://t.co/EMlAhu2aj6
nature.com
Nature Methods - This paper develops two approaches for multiplexing cortical organoids and SCanSNP, a method for deconvolving cell identities, to trace neurodevelopmental trajectories at scale.
📢 Paper alert! Our paper on cortical brain organoids multiplexing is out @naturemethods. https://t.co/5OzaItMkS2 Together with the Research Briefing https://t.co/cjeZGfqn9E /1
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For a quick summary, read the Research Briefing on this work, here:
The team of @gtesta72 have developed methods for multiplexing cortical organoid development to trace neurodevelopmental trajectories at high resolution and at scales. They report SCanSNP, an algorithm to deconvolve cell identities. https://t.co/uzdlxV644S
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The team of @gtesta72 have developed methods for multiplexing cortical organoid development to trace neurodevelopmental trajectories at high resolution and at scales. They report SCanSNP, an algorithm to deconvolve cell identities. https://t.co/uzdlxV644S
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Don't miss the latest study from the @Knoblich_lab ✨ Congratulations @BosoneCamilla, @castaldi_davide, and the team! 🔗
nature.com
Nature Methods - Cortical development is influenced by morphogen gradients. To mimic patterning events during brain development, polarized cortical assembloids are generated with the help of a...
New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain organoids with distinct cortical areas and front-to-back patterning and study human-specific brain development and disorders. Read more: https://t.co/400ZaVys6U
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The @Knoblich_lab has developed polarized cortical assembloids with the help of a localized FGF8 source. This technology allows mimicking patterning events during brain development. @krenn_veronica @BosoneCamilla @castaldi_davide @gtesta72
https://t.co/NTi7mLKxF5
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Excited to share this work now published @naturemethods and to have contributed to develop this interesting model of cortical patterning. A fantastic collaborative work with another @Knoblich_Lab alumnus @BosoneCamilla , @castaldi_davide @CarloEmanueleV1 @humantechnopole
New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain organoids with distinct cortical areas and front-to-back patterning and study human-specific brain development and disorders. Read more: https://t.co/400ZaVys6U
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An immense thanks to all the terrific scientists involved in the project, starting with @BosoneCamilla and @Krenn_veronica for the model conception, @CarloEmanueleV1 as a senior computer scientist, but also @NicoloCaporale, Cristina Cheroni and Thomas Burkard among the others
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Honoured to take part in this fantastic collaborative effort from @gtesta72, @Knoblich_lab, and @krenn_veronica labs, aiming to expand modelling opportunities for human brain through polarized cortical assembloids (polCAs). Check it out on @naturemethods
https://t.co/zi4MfkuGTr
nature.com
Nature Methods - Cortical development is influenced by morphogen gradients. To mimic patterning events during brain development, polarized cortical assembloids are generated with the help of a...
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Celebrating the talent and passion of PhD graduates @RigoliMt and @castaldi_davide @semm_it @humantechnopole @LaStatale following their remarkable scientific journeys that enriched our lab through the years and kudos to their great cosupervisors @NicoloCaporale @AVitriolScience 1
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The first research article from @BaggioliniA lab is finally out! I’m very proud to be part of this great work with great scientists Ryan Walsh @gabriele_ciceri @giacomelli_eli @Rittenhouse_CA @studerl and all collaborators! #organoids #stemcells #neuroscience #braindevelopment
📢📢📢How can we obtain a robust outer radial glia (oRG) population in 🧠organoids from guided differentiation? Exogenous LIF does the trick. Our new paper shows that cortical pericytes are among the cell types secreting LIF. Adding pericytes to cortical organoids recapitulates
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At last! Happy to share our paper on CellOracle – a computational method for dissecting cell identity via network inference and in silico gene perturbation, led by the amazing @kenjikamimoto68:
nature.com
Nature - A machine-learning-based strategy called CellOracle combines computational perturbation with modelling of gene-regulatory networks to analyse how cell identity is regulated by...
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What a better conclusion of my professional path in the #testalab? Our latest Christmas work about #brain #organoids is online. Thanks to CristinaCheroni and all coauthors. Special thanks to @gtesta72 for unparalleled mentorship. Can't wait to start my new adventure!
Celebrating our latest paper published just in time for Christmas in @Transl_Psych
https://t.co/OOWnywMC4V in which we undertook a systematic benchmarking of #brain #organoids recapitulation of human #corticogenesis in terms of #neurodevelopmental timings and processes. Thread
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Continuation of awesome Day 1 and 2 hands-on sessions on scRNA-seq. Thankful to @NicoloCaporale Cristina @CarloEmanueleV1 @castaldi_davide for sharing brilliantly their expertise (and sense of humour!)
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Indeed so much looking forward to welcoming you to @humantechnopole #Brainomics and engaging with your exciting science @GrayCampLab
Curious, Excited to visit @humantechnopole for the first time! Extraordinary things are happening there...Talk on "Organoid Organogenomics" for the BrainOmics course: https://t.co/RsmtOajMBZ). Thanks @TavernaElena @gtesta72 for the invite and organizing!!! #organoids #Omics #SC
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Sono iniziate le riprese di “NUOVO OLIMPO”, nuovo film di Ferzan Ozpetek. Nel cast Damiano Gavino, Andrea Di Luigi, Luisa Ranieri, Greta Scarano, Aurora Giovinazzo, Alvise Rigo e Giancarlo Commare. Il film arriverà su Netflix nel 2023.
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Organoid or Assembloid? The name matters! Our @gtesta72 on @nature provides a unifying framework for the nomenclature of human 3D cellular neural models to facilitate standardization and progress in #neuroscience
https://t.co/gkuy3JAU3M
humantechnopole.it
Nervous system organoids are three-dimensional (3D) cellular models derived from human pluripotent stem cells that represent key tools to study the development of the human nervous system. In a...
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@10xGenomics Can you please improve your default "cell" thresholds. I've seen these sub-standard thresholds negatively impact many studies, here's an example of what I mean:
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