🖨️ Today in @NatureNeuro!. Drs. @TSpiresJones, Claire Durrant, and team conclude that tau pathology could spread at least in part via synapses in progressive supranuclear palsy. 🧠 .

Are you interested in the Rab3 family proteins (Rab3s)? 😃 . Check out this article to know how Rab3s dysregulation disrupts neuronal homeostasis! 🧠 🔄 .

📢 New in @NatureComms!. This study reveals pathogenic mechanisms underlying early neuropathological features of #AlzheimersDisease and identifies the blood ApoM-S1P complex as a potential diagnostic and therapeutic target. 🔗

⏱️ Final week to enter! . Subscribe to one of our 20 immunology or cell biology newsletters before July 18 for a chance to win a personalized lab coat.

📢 New in @NatureComms!. Researchers identify microglial Cx43 hemichannels as a regulator of microglial reactivity in #AlzheimersDisease, positioning them as a promising therapeutic target. 🔗

#Myopia is a serious public health issue worldwide. 👁️. Using single-cell #RNASequencing, researchers have revealed anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia. Read the study:

Register now for On Demand Access to @KeystoneSymp #Neurodegeneration : Linking #CellularPathways to Therapeutic Strategies, this June to explore emerging research! . #KSNeuroDegen25

Register now for On Demand Access to @KeystoneSymp #NeuroImmune Interactions : A Systems Wide Perspective, this June to explore emerging research! . #KSNeuroImmune25

📢 New in @cddpress!. Researchers show that #homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD+/Sirt1 pathway in the brain. This suggests a possible link between hyperhomocysteinemia and #neurodegeneration. 🔗

Interested in the autonomic nervous system? 🤔 . A new @NatRevNeurosci #review from the lab of Dr. Yuki Oka at @Caltech discusses the molecular, anatomical, and functional diversity of autonomic motor neurons. 🔗

📖 In their recent @NatureComms study, @LabPascoal showed that #astrocyte reactivity is closely associated with pre- and post-synaptic dysfunction in patients across the aging and #AlzheimersDisease continuum.

Dr. @pfeffersuzanne and team show that dietary administration of the LRRK2 inhibitor MLi-2 to young LRRK2-mutant mice for 3 months restored primary cilia formation and Hedgehog signaling in both cholinergic and parvalbumin interneurons and #astrocytes.

Researchers led by Dr. Shubha Tole reveal previously unidentified LHX2-dependent mechanisms of dendritic morphogenesis, highlighting its temporally dynamic and diverse roles in neocortical development. 🧠.

Discover the role of dendrites in neocortical GABAergic interneurons with Dr. Annunziato Morabito and colleagues! 😀 . They found that cortical parvalbumin and somatostatin interneurons show distinct dendritic integration properties. 👉

Dr. Graeme Davis and team reported that Sema3a is required for presynaptic homeostatic plasticity at the mouse #neuromuscular junction and that Sema3a is expressed in adult hippocampal pyramidal neurons. 🧠 .

Whether you study glia, synapses, or neural stem cells, Neural Cell News by @STEMCELLTech Science News keeps you informed with the latest research. 🖱️ Subscribe for free, bi-weekly newsletters:

Researchers, including Dr. Eric Baehrecke from @UMassChanSOM, created a conditional Vps13d-knockout mouse to investigate the relationship between mitochondrial health, inflammation, and #neurodegeneration. 💡 Discover more:

Dr. Xinglong Wang and team summarize the current understanding of TDP-43 pathology in #AlzheimersDisease and Alzheimer’s disease-related #dementias, with a focus on its role in disease progression. 📚

😃 Recently from Dr. @Puthanveettil_S' lab! . The team provides insight into the transcriptional networks involved in synaptic plasticity and a lncRNA interactome that mediates dendritically localized regulation of excitatory synaptic transmission and neuronal architecture.

Organ-Chips may help unlock the mystery of #ALS! . Dr. Clive Svendsen's team generated an in vitro model of young-onset sporadic ALS that incorporates dynamic flow across the brain tissue and an integrated blood brain barrier-like component. 🧫.