The Knoblich Lab
@Knoblich_lab
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Research group @IMBA_Vienna and the @viennabiocenter.
Vienna, Austria
Joined March 2019
🎉 As the year winds down, we are filled with gratitude for an inspiring year of science, collaboration, and discovery. Wishing you all a joyful festive season and a bright, groundbreaking 2025 ahead! 🧬🔬🌟
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RT @MedUni_Wien: Increased stress through #DNAbreaks with simultaneous inhibition of #DNArepair in the #tumourcell. ️A team from #MedUniVie….
www.meduniwien.ac.at
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RT @IMBA_Vienna: A new preprint from the @Knoblich_lab and colleagues from @MaxPerutzLabs and @CeMM_News characterizes how different protoc….
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All data is easily accessible in our Vienna brain organoid data explorer. You can look for your favorite gene or search for entire biological processes based on GO Terms. Check it out:
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We also provide RNA-seq data for cell lines in all protocols across organoid development. We quantify sources of variability (1. organoid developmental stage, 2. protocol, 3. cell line) and provide early signatures consistent with protocol-driven organoid derivation.
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By comparison with fetal reference data, we can show that protocol-driven cells largely match cell types found in vivo while cell line-driven cells contribute to in vitro specific cell types.
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Using scRNA-seq and a new measure for comparing scRNA-seq datasets from various sources, the NEST-score, we find protocol-driven cells (generated from many cell lines) as well as outlier, cell line-driven cells (generated from a single cell line only) for each protocol.
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We characterized four regional brain organoid protocols across several cell lines using scRNA-seq on mature organoids and RNA-seq over time to generate a large fraction of human brain cells in vitro.
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Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher_esk) and colleagues across Vienna. @MaxPerutzLabs, @IMBA_Vienna, @CeMM_News.
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RT @ISSCR: Save the date for the Athens International Symposium on 3-4 April 2025! Join scientists as they share their latest research on n….
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RT @IMBA_Vienna: New paper alert! The @Knoblich_Lab partnered with researchers at the @humantechnopole and @unimib to develop new brain org….
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RT @krenn_veronica: Excited to share this work now published @naturemethods and to have contributed to develop this interesting model of co….
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RT @BosoneCamilla: I am beyond happy to share that our polarized cortical assembloid (polCA) paper is out today in Nature Methods! https:/….
www.nature.com
Nature Methods - Cortical development is influenced by morphogen gradients. To mimic patterning events during brain development, polarized cortical assembloids are generated with the help of a...
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RT @naturemethods: The @Knoblich_lab has developed polarized cortical assembloids with the help of a localized FGF8 source. This technology….
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RT @IMBA_Vienna: Chong Li, postdoc at the #Knoblich_Lab, will soon leave IMBA to take a new position as group leader at the Chinese Institu….
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RT @ChongLi_cl: Extremely grateful for the support of the @Knoblich_lab and @IMBA_Vienna during this postdoc journey, where I met amazing s….
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RT @christopher_esk: Wohoo! Great work, @FahrenbergerM , on improving scRNA-seq analyses. Easy to use, implementation in Seurat workflow, b….
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RT @FahrenbergerM: I m happy to present our latest preprint, and the main work of my PhD-project:."GTestimate: Improving relative gene expr….
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RT @catarinacsmc: We're at the cover of Cell Stem Cell. We're at the cover of Cell Stem Cell. We're a-.(I can barely believe it. 🤯). We fou….
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