Brett Heimlich
@brettheimlich
Followers
268
Following
762
Media
13
Statuses
90
Cardiovascular Medicine Fellow, and @VUMC_MedPSTP at @VUMC_Heart. Post doc in @AlexBickMDPhD lab. Former @VUMCMedicineres and @NIH_Fogarty fellow.
Nashville, TN
Joined October 2011
Seeing this in real time at VUMC where 1 in 5 cath lab patients have CHIP. We're building care pathways but standardization across centers would help. Curious what others are doing for longitudinal follow-up. @MichaelR21 @pnatarajanmd @AlexBickMDPhD
The authors advocate for the establishment of dedicated cardiovascular clinics to address the cardiovascular public health burden attributable to Clonal Hematopoiesis of Indeterminant Potential.
0
6
22
We are excited to share our new paper – “IL-17RA signalling modifies cardiovascular disease risk in JAK2 clonal haematopoiesis” published in European Heart Journal 🧬🫀 1/n https://t.co/8vETgTdyG5
@AlexBickMDPhD @yash_pershad @VUMCDiscoveries @ehj_ed
2
8
26
Longitudinal analysis of the LoDoCo2 clinical trial suggests that colchicine blunts TET2 CHIP expansion possibly mediated by reductions in IL-6! These results add to a growing body of evidence that colchicine and IL-6R blockers may be beneficial for CHIP-associated CVD...
In this exploratory analysis, Tx w/ low-dose colchicine was assoc w/ an attenuated annual clonal growth in TET2 CH. Findings suggest potential for colchicine to curb proliferative advantage of key CH driver mutations https://t.co/QipRX2Dn6U
#ESCCongress #WCCardio #JACC @mchonig
2
10
40
We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)
1
7
38
New preprint: teaching single-cell foundation models to learn from perturbations in collaboration with @madduri & @RUNX1Research supported by @cziscience. Closing the loop identified a target for RUNX1-FPD now in Ph2 trials 🔗 https://t.co/tBwGS8sObI 🧵by @yash_persh👇
biorxiv.org
The application of transfer learning models to large scale single-cell datasets has enabled the development of single-cell foundation models (scFMs) that can predict cellular responses to perturbat...
We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)
0
6
38
This is a remarkable feat on so many levels. *Massive* congrats to @kiranmusunuru (former @Circ_Gen EiC & @skathire lab co-alum) @Sarah_Grand @AhrensNicklas & team! https://t.co/xcB87WbPUX
@NEJM (coverage https://t.co/EL59fxpMYn
@nytimes by @ginakolata)
5
42
276
Our latest review, spearheaded by @AmandaDoranLab, on the Bone Marrow Niche in Cardiometabolic Disease is out in @CircRes
@AHA_Research @IUSMDeptMed @VUMCResearch @HHP_UH @CVimmunology @HeatherCaslin @brettheimlich @JonathanBrownMD @FerrellLabVUMC
ahajournals.org
Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow microenv...
1
5
17
Two VUMC physician-scientists named to medical honor society https://t.co/MnKfr95l6W Congrats to @AlexBickMDPhD and @VUMC_MedPSTP alum @JKropski on this well-deserved honor!
news.vumc.org
Vanderbilt’s Alexander Bick, MD, PhD, and Jonathan Kropski, MD, have been elected to the American Society for Clinical Investigation.
0
1
7
Just how many diseases can you identify with a good old 12-lead #ECG? NEW @npjDigitalMed, co-led w/ @lucidtronix, @RVpacing & @xwang, we use an autoencoder to map ECG to phenome, finding associations btwn ECG & >600 conditions @broadinstitute @broad_ml4h @MGHHeartHealth LINK⬇️
6
38
129
Alex Reiner @fredhutch, @AlexBickMDPhD, and I are excited to share our new preprint, “Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women” https://t.co/Q3H7OhIwjE 1/n
medrxiv.org
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed...
2
12
36
Congratulations to @statnews 2024 wunderkind @DrFlashHeart! Caitlyn has authored more than two dozen papers with our group in the past two years on #CHIP, firmly establishing it as a risk factor for kidney disease and beyond. @VUMCgenetics
https://t.co/Pdfti7DmLs
statnews.com
This physician-scientist’s discovery could help stop or slow damage to kidneys Ahmed Ahmed blends public policy with medicine to learn about the healthcare workforce. Read his story.
13
10
98
.@AlexBickMDPhD, a physician-scientist at Vanderbilt University Medical Center who is known for his research on the genetics of blood disorders, has been named director of the Division of Genetic Medicine. Congrats, Dr. Bick! @VUMCgenetics @VUMC_Medicine
https://t.co/lPiYSIeAlY
news.vumc.org
Alexander Bick, MD, PhD, has been named director of Vanderbilt University Medical Center's Division of Genetic Medicine.
0
4
43
We are excited to share our new preprint “Variance quantitative trait loci reveal gene-gene interactions which alter blood traits”! https://t.co/a4kjnvcwxI. Thread below 🧵 1/n
medrxiv.org
Gene-gene (GxG) interactions play an important role in human genetics, potentially explaining part of the “missing heritability” of polygenic traits and the variable expressivity of monogenic traits....
3
7
37
Congratulations to @alyssa_c_parker from our group on receiving the 2024 Basic Sciences Dean's Award!
🎉 Congratulations to the 2024 Basic Sciences Dean's Award winners who were recognized for their high academic and scientific achievement and for the originality, significance, and rigor of their dissertation research. 🌟🔬 Learn more 👉
1
2
20
Congratulations Dr. @taralynn_mack on a spectacular PhD defense! Your science, mentorship and leadership in the lab and across campus is an inspiration. It has been such a privilege to learn together the past 3 years. @VUMCgenetics @VUBasicSciences @VUmedicine @VUMCDiscoveries
1
6
42
Excited to share our paper @Laventaobare @tecla_temu @VUMC_heart @VUMC_MedPSTP @VI4Research , "Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease" now published in @CircRes
https://t.co/FsFDTB9aFU
3
7
25
Huge shout out to my coauthors @alyssa_c_parker and @PBdoingscience for their help as well as my mentors @AlexBickMDPhD and @FerrellLabVUMC for their support!
0
0
4
Using lineage tracing, we were able to isolate transcriptional states from mutated CHIP cells ex-vivo, identifying several potential inflammatory targets for precision treatment approaches.
2
0
3
Surprisingly, T cells from CHIP patients also had signs of dysfunction, despite minimal mutation burden. GIMAPs, important in T cell health, were decreased in CHIP.
1
0
2
Further, we found the mutant monocytes to have specific signaling and gene expression patterns which were mutation specific, though both mutations had an altered inflammatory axis.
1
0
2