Michael Raddatz
@MichaelR21
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Bluesky: https://t.co/rCEDp2MxpY Cardiology fellow @UCLA. Partner to @DemetraHufnagel.
Los Angeles, CA
Joined March 2009
Using a unique cohort of 10k doubly sequenced people in @VUMCDiscoveries's BioVU, @AlexBickMDPhD, @yash_pershad, and I investigated how well #WGS data really works for detecting #CHIP. https://t.co/b2lwSugwgG. Thread below! 1/n
medrxiv.org
Clonal hematopoiesis of indeterminate potential (CHIP) occurs when at least 4% of blood cells harbor somatic mutations in leukemogenic genes and is associated with increased risk for cardiovascular...
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@datsunian emphasizes the teamwork needed for recognizing and treating #CVD risk factors in patients with #cancer, as well as monitoring LV function within 1 year post #anthracycline therapy #cardioonc @CaliforniaACC #ACCCVT Symposium @UCLAHealth @BrentonBauerMD
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9/9 In summary, CRP-rich plasma from Long COVID patients ⬆️ platelet activation, and platelet activation correlates with the severity of 🫁 damage. Platelet activation is reversible with aspirin or P2Y12. Read the paper in this month’s issue of #JACCBTS! https://t.co/5aSKdii6tD
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8/ Aspirin or a P2Y12-inhibitor also reversed the platelet activation effects of Long COVID plasma, suggesting that these readily available treatments could be useful in this disorder.
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7/ The authors showed that platelet activation was further potentiated by IL-6 in the presence of CRP, thus they attempted to inhibit 🛑 platelet activation through CRP and IL-6. Platelet activation was reversed with FcgRi or tocilizumab, inhibiting CRP and IL-6, respectively.
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6/ They hypothesized that circulating factors were priming platelets in Long COVID patients and treated platelets from healthy subjects with different types of plasma. Indeed, Long COVID plasma ⬆️ P-selectin expression and PGAs in otherwise healthy platelets.
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5/ PGA and PMA also correlated with parenchymal lung damage in these patients. 🫁
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4/ Compared to both COVID recovered patients and healthy subjects, Long COVID patients had ⬆️ measures of platelet activation, including platelet-granulocyte aggregates (PGA) and platelet-monocyte aggregates (PMA).
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3/ Across patient groups, those with Long COVID and Acute COVID had ⬆️ CRP compared to recovered patients. Acutely infected patients also had ⬆️ IL-6, D-Dimer, and fibrinogen, which were not elevated in Long COVID.
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2/ The authors previously showed in #JACCBTS that post-COVID pts have ⬆️ platelet activation https://t.co/wy8CQmjjKe. However, they looked to test this in Long COVID syndrome. Long COVID patients in this study were those who continued to have symptoms 6 mos post-infection. 🤒
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In this month’s issue of #JACCBTS, Brambilla, et al. explore the role of platelet function in long COVID. Read below ⬇️ to see what they found! 🧵 1/n
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I am honored to be elected to @the_asci! I am deeply grateful for the support from my incredible trainees and mentors @VUMCgenetics @VUMC_Medicine @VUMC_Cancer @VUMCDiscoveries that made this possible. https://t.co/XwSXVuJfVj
news.vumc.org
Vanderbilt’s Alexander Bick, MD, PhD, and Jonathan Kropski, MD, have been elected to the American Society for Clinical Investigation.
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Alex Reiner @fredhutch, @AlexBickMDPhD, and I are excited to share our new preprint, “Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women” https://t.co/Q3H7OhIwjE 1/n
medrxiv.org
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed...
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...@uclaCVfellows STAR #bruinhearts fellow @MichaelR21 @AlexBickMDPhD provide this great overview of the increasing potential and role of clonal hematopoiesis of indeterminate potential & itsassociations w/ CV disease. #CHIP
https://t.co/KeN6MwdUdM 4/ 🧵
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@A_SteinMerlob & I are excited to present in #CardiologyClinics @ELS_Cardiology: Feb 2025 #Cardioonc Section Issue Special🙏to @jamil_aboulhosn & editors for inviting us to commission this issue & 🙏all the authors for providing their expertise! 1/🧵 https://t.co/o132d4CfUI
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WELCOME to our @uclaCVfellows Class of 2028!! An incredible crew and grateful to our incredible team @kewatson @netta_doc @justinhayase
#asimrafique & faculty/fellows for their recruitment efforts! We are so thrilled that you are joining the #bruinhearts family! @UCLAHealth
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Congratulations to all match day celebrators—excited to welcome our new class to UCLA!
WELCOME to our @uclaCVfellows Class of 2028!! An incredible crew and grateful to our incredible team @kewatson @netta_doc @justinhayase
#asimrafique & faculty/fellows for their recruitment efforts! We are so thrilled that you are joining the #bruinhearts family! @UCLAHealth
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9/9 In summary, lentiviral-mediated HLA suppression can suppress non-self-recognition in explanted valves, perhaps offering a strategy for decreased immunogenicity in heart valve transplants. Read the full paper in this month’s issue of #JACCBTS! https://t.co/SolmZK7SJl
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8/ Transitioning to the immune-active lentivirus carrying US2 and serpin 9, they show the same pattern with effective HLA suppression in the valves.
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7/ The next question was whether this strategy would work in a three-dimensional tissue structure like the valve. Using the GFP reporter in four human valve states, they show that lentiviral transduction is efficient up to 700 microns.
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