
Moshe Biton
@bitonm
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Rehovot, Israel
Joined January 2011
Our latest preprint is out! ๐จWe discovered that intestinal stem cells actively fight bacterial infections. Learn more about it in our new study by @SachaLEBON in collaboration with @matanhofree
biorxiv.org
Intestinal stem cells (ISCs) are the regenerative force of the gut epithelium. Lgr5+-ISC have been shown to respond to changes in their microenvironment by coping with different metabolites, adapting...
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How weโre rebuilding the Weizmann Institute โ and our hopes for a better future
nature.com
Nature - Scientific research is at the heart of Israelโs success and has worldwide benefits. Our work will continue despite adversity.
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Proud to see this study from our @bitonslab in collaboration with @LabSagi now on @biorxivpreprint! Brilliant work by the team, congrats!
Excited to share our latest preprint with @Sagi_Lab on @biorxivpreprint! The ECM remembers inflammationโforming a scarred niche that reprograms stem cells and drives chronic disease. The ECM isn't passiveโit instructs. ๐ https://t.co/AFlo434OA5
#IBD #ECM #StemCells #Inflammation
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Out now in @Science! We and the @KuchrooLab described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity. https://t.co/jel4IWa6K9
science.org
Enteric nervous system (ENS)โderived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is...
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ืืืื ืืืจืกืืื ืืขืืจืืช ืืื ืืืจื ืืช ืคืจืืค' ืื ืื ืื-ื ืจืื ืืืคืงืืืื ืืจืคืืื ืขื ืืืืืชื ืืคืจืก ืืฉืจืื ืืชืืื ืืงืจ ืืจืคืืื, ืขื ืคืืขืื ืืืงืจ ืืืืช ืืกืจืื. ืืขืืช ืืคืจืก ืฆืืื ื ืื ืืืืงืื ืื "ืคืจืืค' ืื-ื ืจืื ืืื ืืืงืจ ืคืืจืฅ ืืจื ืืชืืื ืืงืจ ืืืืช ืืกืจืื, ืฉืืืื ืื ืื ืื ืื ืืืชืคืชืืืช ืืกืจืื ืฉืืืืืื ืืขืืืื ืืืืืืื ืืืฆืืจืช ืชืจืืคืืช
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๐Excited to share that our PI Vijay Kuchroo will be awarded the 2025 AAI-Thermo Fisher Meritorious Career Award, for outstanding research contributions to immunology. Vijay will be presented the award & giving a lecture in Honolulu at the annual @ImmunologyAAI meeting in May.
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1/ Keen to share the story of my postdoc research in @TheXavierLab! We built a massive resource characterizing the spatial landscape of the gut, and yes, we dug deep into the biology too. If youโve got a minute, let me walk you through the story. ๐งต๐ https://t.co/sKL3yyCCKZ
nature.com
Nature - Intestinal regionalization is characterized by robust and resilient structural cell states and the intestine can adapt to environmental stress in a spatially controlled manner through...
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Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! https://t.co/NYQRHfq3gz
https://t.co/Z4GFwqL8G2. A ๐งต
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This paper exemplifies the power of @MSKCancerCenter and why I love working here. Access to unique tumor samples, more importantly brilliant physician scientists and most important driven and talented trainees to make it all happen. Kudus to @andrewrmoorman and @elliebenitez11
๐จ NEW: A study published in @nature overseen by MSK's @KarunaMDPhD and @dana_peer illuminates differences between primary & metastatic #colorectalcancer. Researchers say understanding the differences may lead to new therapeutic opportunities. Learn more: https://t.co/YbEQwHR76B
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Preprint alert! A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology https://t.co/qtyqlepJod. We examined how immune cells are organized in the gut and what happens to them in GVHD. TL;DR Timing is key!
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Exciting collab with @Honda1Kenyaโs lab, out today in @Nature: A set of microbial strains taken from a human faecal donor can decolonize multidrug-resistant Enterobacteriaceae in the gut, including species associated with #IBD. (1/3)
nature.com
Nature - Transplants of consortia with limited numbers of strains of commensal bacteria derived from healthy human stool samples are able to suppress intestinal Enterobacteriaceae by regulating...
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Highly relevant work from @TheXavierLab and @Honda1Kenya lab showing a defined bacterial consortium with the capacity to decolonize multidrug-resistant pathogens. Important implications for treating #IBD with defined FMT protocols Exciting times!
Exciting collab with @Honda1Kenyaโs lab, out today in @Nature: A set of microbial strains taken from a human faecal donor can decolonize multidrug-resistant Enterobacteriaceae in the gut, including species associated with #IBD. (1/3)
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๐จ Thrilled to share my first first-author preprint on bioRxiv! ๐จ https://t.co/IRy8hKnviy ๐ก Major breakthrough: Intestinal stem cells fight bacterial infection by differentiation into Paneth cells through inflammasome activation! ๐ฆ โ๏ธ 1/
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A Cellular Atlas of Gut Inflammation
the-scientist.com
Researchers mapped tissue remodeling during colitis development in mice to explore how diverse cell types contribute and respond to the disease. ย
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Excited to share the Smillie Lab's first paper! We discovered distinct lineages of the gut microbiota that are exquisitely adapted to inflammatory disease. This was a monumental effort led by Adarsh Kumbhari @mgh_ri @harvardmed @broadinstitute More: https://t.co/rmfnCdyORP
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i am so excited about our open source inexpensive, sub-cellular capture, do-it-yourself Open-ST that transforms tissues into virtual tissue blocks in 3D - IDing pathways & gene programs driving phenotypes. a huge congratz to the team!
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Together with @IdoAmitLab weโre very excited to introduce BiCE (Bispecific DC-T Cell Engager)- a new platform to engineer immune cell communication for #cancer #immunotherapy. Led by the amazing @yuval_shap @orenbarboy, now out @CellCellPress: https://t.co/COVWAN7Tbf (1/11)
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Congratulations to Dr. @roi1avraham of the Immunology and Regenerative Biology Department upon being elected an Outstanding Early Career Investigator by the American Society for Microbiology.
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If youโre interested in host-microbiota interactions but like your microbes with membrane bound organelles then our paper on symbiotic protists is for you @CellCellPress . Congrats @GerrickElias and a huge thank you to all our collaborators!
cell.com
The differing metabolisms of commensal protists and bacteria in the gut microbiome shape the ability of these distinct microbes to interact with and modulate each other and the host immune system.
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