Roni Nowarski
@NowarskiLab
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Studying how interactions between tissue and immune cells shape immunity and inflammation @harvardmed and @BrighamWomens
Joined May 2023
Speakers from @BrighamWomens/@harvardmed, @cwru, @cinvestav will provide insights into various aspects of innate and adoptive #immunity in #inflammation. Check out the full #Pathobiology2025 program https://t.co/B4Q4E1YIqh
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Imagine there's no treatment It's easy if you see Nothing to fight your cancer Or autoimmunity Imagine all the research Ceasing to exist Woo-hoo hoooo
Can you believe that universities with tens of billions in endowments were siphoning off 60% of research award money for “overhead”? What a ripoff!
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A terrific synopsis of bistability in innate immune signaling by Jayajit Das and Giuseppe Giuliani, previewing our paper on macrophage tolerogenic memory published today @Immunity
https://t.co/qIGIV0IIC3
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A Cellular Atlas of Gut Inflammation
the-scientist.com
Researchers mapped tissue remodeling during colitis development in mice to explore how diverse cell types contribute and respond to the disease.
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Our new work published today @NatrureMedicine
https://t.co/GaQVx8wUQP The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann). Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab
nature.com
Nature Medicine - APOE4-dependent neutrophil–microglia interactions drive cognitive impairment in female carriers with Alzheimer’s disease via IL-17F.
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Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.
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New research from @NowarskiLab uncovers a 'switch' in the gut that can provide protection against harmful intestinal inflammation. The work was published in @ImmunityCP
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@ImmunityCP A must read for anyone interested in how innate immune signals impact intestinal inflammation.
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Incredibly proud of Tyler Mertens, Aditya Misra @amisra96, Peng Xiao and the team for figuring it out! Big thanks to @FlavellLab, @m_hemberg, @KanarekNaama and @AnaAndersonlab! Read more here @ImmunityCP:
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This tolerogenic state is maintained and reinforced in macrophages by a bistable circuit driven by cGAS-STING activation, and by an intercellular positive feedback loop sustaining epithelial IL-18 and macrophage cGAMP secretion.
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Very excited to share our paper showing that IL-18 activation of the salt transporter NCC programs durable immune tolerance in the gut! We found that NCC induces a metabolic switch in macrophages that stabilizes fatty acid oxidation and prevents glycolytic reprogramming ⬇️
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Thrilled to have our work mapping tissue remodeling in intestinal inflammation online! An amazing collaboration between @SivanathanKisha and Paolo and Jeff in the @MoffittLab probing the diversity and origin of #inflammation associated #fibroblasts. https://t.co/9QbwgmEvp9
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If you don't live in Israel or consume Israeli media, you don't know who Yair Golan is. He is a 61-year-old retired Major General in the Israel army and a former parliament MP. Spend a minute to read this story. Yesterday, when IDF and the police were in complete chaos, Golan
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Taking a break from the Harvard Immunology retreat for a Colgate audition
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So proud of Aditya Misra @amisra96 for being selected as a @MathWorks Engineering Fellow in recognition of "outstanding academic record, exceptional background, and promising future". Keep at it Rockstar!
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The most beautiful spatial paper I have seen, a notch (or two) above all the rest. Congratulations to the team.
#Colitis is a complex form of #IBD & #MERFISH #SpatialTranscriptomics can be used to study it! Researchers led by Dr. Jeff Moffitt from @BostonChildrens developed a framework for studying inflammation-induced #GutRemodleing in mice.🐭 Read the preprint: https://t.co/mkMxyUPK8F
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Excited to announce the results of an exciting collaboration with Jeff Moffitt and @MoffittLab at @harvardmed, where we charted the cellular organization of the #gut and show how #inflammation shapes fibroblast trajectories and tissue remodeling! https://t.co/r3hrTvdouW
biorxiv.org
Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The...
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