Karuna Ganesh
@KarunaMDPhD
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@karunamdphd.bsky.social Physician Scientist at Memorial Sloan Kettering | Metastasis | Plasticity | Colorectal Cancer | Regeneration | Stem Cells | Organoids
Joined June 2018
Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! A 🧵
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RT @MSKCancerCenter: MSK researchers are working to better understand #metastasis and pointing toward new opportunities for potential #canc….
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Exciting and important work on how regulation of gene expression is coupled with protein function 👇🏽.
More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.
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RT @MSKCancerCenter: @kevinmboehm @scgerstberger 3/3 Dr. Stefanie Gerstberger, a third-year medical oncology fellow and postdoc researcher….
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Congratulations Stefanie.
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📷.#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student @wgsmahmoud @WeillCornellGS @HHMINEWS .
biorxiv.org
Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on...
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Congratulations @Yael_David__ and team! Gorgeous science.
A team of researchers from MSK, @WeillCornell, and @RockefellerUniv uncovered a new potential strategy against the hepatitis B virus (HBV), one of the leading causes of liver cancer. MSK's @Yael_David__ and colleagues successfully disrupted the hepatitis B virus’s ability to
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Some great news: incredibly proud of our Medical Oncology Fellow Jaeyop Lee MD, PhD comentored by David Scheinberg, who just received the NoA for an NCI K99/R00 award!!! Stay tuned for his groundbreaking work on CRC immunotherapy @KarunaGaneshLab @MSK_DeptOfMed @MSKCancerCenter
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RT @MaraShermanLab: Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏾💪🏻💪, we ID potential of normal mese….
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No better feeling than seeing trainees do brilliantly. Super proud of @Qingwen_J! Stay tuned for her work…. #proudPI.
Ganesh Lab post-doc @QingwenJ gave a fantastic talk on tumor regeneration and metastasis at the @MSKCancerCenter #GMTEC 2025 symposium. Peek @KarunaMDPhD being a proud PI!
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Congratulations @MaraShermanLab and other winners!.
📢Announcing The Mark Foundation 2025 Emerging Leader Award winners! 📢 . These 5 outstanding early-career scientists will receive a total of $3.75M to pursue projects with the potential to transform cancer research. We can’t wait to see what they achieve!.
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Congratulations Samra and team! Exciting work on non-genetic tumor evolution in metastasis, here in ccRCC 👇🏽👇🏽👇🏽.
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RT @DamonRunyon: Metastasis accounts for most cancer deaths. A new study from Damon Runyon alum @KarunaMDPhD reveals why metastatic tumors….
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RT @MetastasisRS: 2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to feta….
nature.com
Nature - Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.
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RT @aventura71: 1/ 🚨New paper on ecDNAs from our lab! . We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cel….
nature.com
Nature - Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role...
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Congratulations @thenormanlab #perturbseq experts on this exciting paper!.
Our Multiome Perturb-seq paper is now out in @CellSystemsCP! As discussed in my thread on the preprint, this is an approach for linking CRISPR-mediated genetic perturbations to their effects on cellular chromatin state and gene expression.
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RT @LabSethi: Aberrations in epigenetic regulation prevent cellular differentiation and endow plasticity to cancer….
biorxiv.org
Dysregulated epigenetic programs that restrict differentiation, reactivate fetal genes, and confer phenotypic plasticity are critical to colorectal cancer (CRC) development. By screening a small...
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RT @Aiims1742: This graph of annual percentage change in incidence of young onset #ColorectalCancer versus the rest of the age groups alway….
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Great story from @TuomasTammela @Xueqian_Zhuang and team on lung stem cell ageing and declining tumorigenic fitness. Congratulations!.
Several years in the making (and aging), @Xueqian_Zhuang 's study on aging is out today @Nature. She finds, surprisingly, that aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium.
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RT @bengrbm: Excited to share our latest work in @ImmunityCP led by our own @sunsiyu1 @CompOncMSK @MSKCancerCenter, who tried to assemble t….
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