Xavier Lab
@TheXavierLab
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Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity. https://t.co/fsw4zVpmOE
Cambridge, MA
Joined September 2020
For a great example of complex science presented clearly and compellingly, check out this Base by Base PaperCast episode! It covers a recent @FinnGen_FI study showing protective effects of CFHR5 loss-of-function against age-related macular degeneration. (1/2).
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Online now a multicenter Crohn's Disease study of South Asian patients that explores environmental impacts on #CD, linking geography and immigrant status with disease presentation and serologic markers. #crohnsdisease.
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Check out our recent work with John Rioux and the iGenoMed Consortium! Serum proteomic and metabolomic profiling in #IBD patients initiating vedolizumab identified pro-inflammatory analytes associated with treatment response.
onlinelibrary.wiley.com
In this article, we have analyzed the serum proteome and metabolome in inflammatory bowel disease patients being treated with the anti-α4β7 integrin therapeutic agent vedolizumab. The pretreatment...
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. independent fashion. This finding suggests that molecular patterns could be more useful categories for microbiome-driven immune regulation than taxonomy. Read the study in JACS – @broadinstitute.@MGHMolBio.@MGBResearchNews.
pubs.acs.org
Eggerthella lenta is both one of the most studied and least understood members of the human gut microbiome. Most of the interest in this Gram-positive anaerobe originates from multiple robust...
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In our latest collab w/the Clardy Lab @HarvardMed to mine microbial metabolites for immunomodulators, we identified how Eggerthella lent—one of the most studied & least understood members of the human gut microbiome—upregulates inflammatory responses in a cell- & antigen- (cont.).
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. and maps expression of genetic risk variants onto intestinal biogeography. @broadinstitute @MGBResearchNews @MGHMolBio @GeneLayInst.
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Very excited to share our latest work in @NatureGenet w/ @cssmillie’s lab: a spatial transcriptomics atlas of stricturing #Crohns disease that offers new insights into mechanisms driving fibrotic complications in chronic gut inflammation. (cont.).
nature.com
Nature Genetics - Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of...
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Congratulations to co-first authors @ericmichbrown and @emilytemple_ on this important work!. @broadinstitute @MGBResearchNews @MGHMolBio @GeneLayInst.
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RT @LabWaggoner: Bacterial sphingolipids delivered by outer membrane vesicles persist within mammalian immune cells and promote IL-10 secre….
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(5/6) This suggests that OMV-like nanoparticles could one day be used to deliver vaccines or therapeutics to immune cells! We are thrilled to have this paper out in the world.
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(4/6) These findings are exciting for a few reasons. Not only do they clarify the mechanism of a microbiome-host interaction that is important in inflammatory disease, they add to the mounting evidence that OMVs can be an effective vehicle for immunomodulatory signaling.
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(3/6) We found that OMVs secreted by Bacteroides deliver sphingolipids into host immune cells, activating mevalonate (cholesterol biosynthesis) pathway genes and increasing anti-inflammatory IL-10 secretion. The IL-10 response is dependent upon the mevalonate pathway activation.
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(2/6) Bacteroides species are ubiquitous in the human gut #microbiome. Unlike most bacteria, their membranes contain sphingolipids (SLs), whose abundance in the gut negatively correlates with #inflammation. We wanted to understand the role of SLs in microbiome-host interactions.
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(1/6) Exciting! Our latest paper in @cellhostmicrobe shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway.
cell.com
Brown et al. show that bacterial sphingolipids delivered by outer membrane vesicles (OMVs) persist within mammalian immune cells and promote IL-10 secretion via the mevalonate pathway. This sphingo...
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RT @KuchrooLab: 🚨New paper with @TheXavierLab @ScienceMagazine on the critical role of 🔁neuroimmune crosstalk in immune defense in the gut!….
science.org
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is...
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Out now in @Science! We and the @KuchrooLab described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity.
science.org
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is...
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Thrilled to share that Rebecca Cohen, one of our outstanding clinical research coordinators, will join the Johns Hopkins ScM program in Molecular Microbiology & Immunology. Congratulations, Rebecca — wishing you continued success in this exciting next chapter! @JohnsHopkinsSPH📚.
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🎉 Huge congrats to Joanna Atwater, one of our amazing clinical research coordinators, on her next big step — pursuing a DMD at Tufts University School of Dental Medicine! Wishing you all the best on this exciting journey! 🦷📚 #FutureDentist #TuftsDental.
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A big congratulations to Xavier lab member Felicia Houttuijn Bloemendaal who has been awarded a prestigious European Marie Sklodowska-Curie postdoctoral fellowship to support her work on characterizing enteric neurons in human disease!!.
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