🚨 Thrilled to share my first first-author preprint on bioRxiv! 🚨 https://t.co/IRy8hKnviy 💡 Major breakthrough: Intestinal stem cells fight bacterial infection by differentiation into Paneth cells through inflammasome activation! 🦠⚔️ 1/
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Using single-cell RNA seq, we reveal how the intestinal epithelium mounts a rapid antimicrobial response against bacterial infection as fast as 24 hours. 2/
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Even cooler, we pinpointed the cell subsets invaded by Salmonella and uncovered the unique transcriptional responses of both invaded and bystander cells. 🧬 3/
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Our work shows that ISCs don’t just passively maintain the epithelial barrier — they play an active, frontline role of defence against bacterial pathogens! 🦠💥 4/
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👀 What’s even more exciting? We confirmed this Lgr5+ ISC defence mechanism in human intestinal organoids, which might suggest its potential relevance to human diseases like #IBD. 🌍 5/
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🙏 Big shoutout to my amazing co-authors from @bitonm lab, @matanhofree lab and @WeizmannScience community for their contributions! Read the full paper here: https://t.co/IRy8hKnviy
#GutScience #StemCells #MucosalImmunity #PanethCells 6/6
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