addison_webster
@addisonwebster0
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how does the brain regulate appetite and metabolism? 🧠 UVA PhD student in the Campbell Lab
Joined March 2022
Happy to share our work on hippocampal inflammasome signaling. Thank you to members of the lab for critical experimental support, @BIG_Center_UVA colleagues for input, and @LukensJohnR for baller mentorship - it's been an honor working with you all!
cell.com
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in...
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I’m excited to share our publication from @Dulac_lab in @Nature, where we illuminate the development of hypothalamic cell types involved in a broad range of functions, from social behaviors to thirst, thermoregulation, and sleep. Highlights below! 🧵 https://t.co/cxL7xBupQk
nature.com
Nature - Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell...
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🚨 New paper in @Nature! 🚨 We’ve mapped the human hypothalamus in unprecedented detail, revealing key differences from mice & unlocking insights into obesity, metabolism & drug development. Meet HYPOMAP—a cellular Google Maps for the brain’s metabolic control centre. 🧵(1/)
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You just can't leave the dessert even though you're full? 🍰 Blame it on your POMC neurons!🧠 (details ➡️🧵) Congratulations to Marielle Minère, @FenselauHenning and all other authors for their newest publication @ScienceMagazine ! 🎉 https://t.co/u8av0ssiEP 1/3
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A dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating https://t.co/SQJNvrJNmp
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A little late for Thanksgiving but if you have friends and family members curious about anti-obesity medications, this is very easy to digest piece (nailed that pun....still got it)
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Molecular connectomics identify local inputs to AgRP neurons and reveal a circuit through which GLP-1RAs suppress appetite in mice @NatMetabolism
nature.com
Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.
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New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite
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Proud to share our recent collaboration, which combines rabies tracing with single cell sequencing to identify a novel GLP1R-expressing pre-syanptic partner to AgRP neurons @AUGCsoup @michael_krashes
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The first opus of @mrbrown715's thesis work is now live in @glia_journal, exploring the role of enteric glial cells in antigen presentation!
onlinelibrary.wiley.com
Enteric Glial Cells (EGCs) are capable of antigen presentation in vitro via MHC I, but not MHC II EGCs upregulate cell surface MHC I/II during acute Toxoplasma gondii infection, though MHC II...
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Genetically defined neuron types underlying visuomotor transformation in the superior colliculus: https://t.co/bi33EeCu2M "Here, we review these recent discoveries on the cell types and neuronal circuits underlying visuomotor transformations mediated by the superior colliculus"
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🎉 New research group "Neurogenomics" headed by Lukas Steuernagel! 🧠🔬 Lukas dives into the fascinating world of the hypothalamus with a focus on bioinformatics. @CECAD_ @CGA_age
https://t.co/Vw5dlN5n9g
sf.mpg.de
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Sarm1 is not just for axons anymore. Check out our new preprint. Congrats to Katya Stepanova and the team.
biorxiv.org
Schwann cells (SCs) transition into a repair phenotype after peripheral nerve injury, which is crucial for supporting axon regeneration. However, the early SC injury response preceding the repair...
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Congratulations @Lowensteined @LiLi_Phd2017 Jason Le, @_anngru_ @oatneill @ForrestDRogers_ @addisonwebster0 @ivancalcantara @FrontalCortes !! #HypoGRC
Congratulations to all the HypoGRC poster award winners! 🏅
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🚨Paper alert! Exiting new research from the Fenselau and Brüning lab discovered a mechanism of synaptic plasticity that controls hunger and anxiety signaling by tuning neurocircuits depending on the energy level. 🧠 @NatureComms
https://t.co/eK6p3vstRs
nature.com
Nature Communications - Neuropeptides are potent feeding modulators, but how these endogenous signals shape relevant neurocircuits remains unclear. Here, the authors show that hypothalamic...
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UVA Brain Awareness Outreach is hosting an art show featuring pieces made by UVA researchers & Cville HS students based on research by UVA Neuroscience & Biology. The show will be up 3/22-3/31 @ The Bridge Progressive Arts Initiative (306 Main St.), entrance is FREE!
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🌟 Good News: Wir fördern als #DAAD ab April 114 Projekte an über 100 🇩🇪 Hochschulen, um internationale Studierende stärker als zukünftige #Fachkräfte zu qualifizieren. Rund 120 Mio. € stehen bis 2028 vom @BMBF_Bund dafür bereit. #Bildungszukunft
https://t.co/WlYdTH8RQA 👏👏👏
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Why do we love cake and ice cream? My lab's latest paper in @Cell_Metabolism led by @molly_mcdougle identifies separate gut-reward circuits for fat and sugar. Foods combining fat and sugar recruit both reward circuits to increase motivation to overeating.
New #PrePrint Alert! So proud to share our latest work examining the innate motivation to consume fats and sugars. We identify labeled lines for fat and sugar reward from the gut via nigrostriatal dopamine that combine to promote overeating.
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I wrote down my rules on how to Science. I hope you find it useful!
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Congrats to @JingCai_1 on her new publication in Neuron @NeuronCellPress
https://t.co/yRgpUBcjcE of the preprint https://t.co/KSRTz8c23u with significant update thanks to insightful comments from reviewers. Thanks @yulonglilab @DrYongXu1 and others for help!
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