Yulong Li Lab
@yulonglilab
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Yulong Li: PKU (BS, Beijing) - Duke Univ. (PhD, Durham) - Stanford Univ. (Postdoc, Palo Alto) - PKU (Prof. , Beijing)
Beijing, China
Joined November 2018
以前に告知させて頂いた、こちらのYulong Li先生のセミナーですが、時間が変更になりました！日にちと場所は同じままです。皆様、ぜひぜひご参加ください！ 11月10日（月曜）11:00開始です。 https://t.co/e5JRLfay3z
少し先になりますが、11月10日（月曜）16時より、東京大学定量生命科学研究所本館でYulong Li先生にご講演頂きます。 脳内における物質動態を可視化できる多様なセンサー開発の最前線についてお話し頂けると思いますので、ご興味がある方は是非！ https://t.co/e5JRLfay3z
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Happy to write a small piece regarding the recent advancement of red calcium and potassium sensors by the Piatkevich lab@westlake!
Great commentary by @yulonglilab on our two recent papers introducing red genetically encoded biosensors for calcium and potassium imaging! 🔴 FRCaMPi - Enhanced red calcium sensor 🔴 RGEPOs - First-ever red potassium sensors 📖 https://t.co/6598F2iTr7
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Happy to visit University of Tokyo and get connected with old friends and meet new colleagues:)
少し先になりますが、11月10日（月曜）16時より、東京大学定量生命科学研究所本館でYulong Li先生にご講演頂きます。 脳内における物質動態を可視化できる多様なセンサー開発の最前線についてお話し頂けると思いますので、ご興味がある方は是非！ https://t.co/e5JRLfay3z
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Spatial resolved ACh dynamics in vivo by 2P imaging. Cool study by Feng and Daniel! Congrats!
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Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement: Cell Reports
cell.com
Xuan et al. measure release of the brain modulation chemical acetylcholine in the mouse hippocampus with micron scale and sub-second resolution. They find increases in release related to heightened...
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Having trouble getting the probes or dyes? Contact us at yulonglilab2018@gmail.com — we will be more than happy to help.
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Glad to see Yu Zheng PhD highlighting the far-red dopamine sensor for multiplex imaging of in vivo neuromodulation. Happy to share these probes to the community.
A far-red dopamine sensor unlocks multiplex views of in vivo neuromodulation — a Tools of the Trade article by Yu Zheng @yu98449099 @YulongLiLab
https://t.co/dVdCPQo8fB
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Glad to see the neural sensor jointly developed by Prof. Li Yulong’s Lab at PKU and the Instituto de Neurociencias UMH-CSIC contribute to a new publication in Nature Communications, advancing our understanding of vasopressin neuromodulation and social behavior. At PKU, we remain
In a mouse model with a Shank3 mutation, researchers found impaired vasopressin release in the lateral septum. Using a new biosensor co-developed with @yulonglilab at @PKU1898, they visualized this process in real time for the first time. 📷@NatureComms
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"I learned that any difficult problem can be solved by great effort." Remembering Osamu Shimomura, born #OTD in 1928, who dedicated his life to studying the bioluminescence of the luminous jellyfish Aequorea, and discovered green fluorescent protein, GFP.
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6/ Sustained serotonin release in vCA1 keeps 5-HT2C–expressing pyramidal neuron ensembles, linking temporally separated events. When the gap exceeds the brain’s “safe window”, brief serotonin release fails to drive these ensembles, thus preventing maladaptive learning.
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5/ We mapped molecular specificity in vCA1 using multiplex FISH technique (thanks to Yanyi Huang & Tianyi Chang), and showed that serotonin modulates the associable window via 5-HT2C-expressing pyramidal neurons with CRISPR-Cas9 based gene perturbations.
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4/ Using temporally precise optogenetics, we causally linked DRN→vCA1 serotonergic projections to the regulation of the associable interval in trace fear conditioning.
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3/We found that serotonin is the key. In trace fear conditioning, systemic serotonin manipulations bidirectionally shift the associable interval. Using our 5-HT3.0 sensor, we showed real-time,in vivo evidence that serotonin release patterns in vCA1 tightly track this time window.
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2/ The brain needs tight temporal boundaries for associations of cues and threats. Too narrow → We might miss real threats. Too wide → We might create false alarms. The question: What keeps this window just right?
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1/ Excited to share a new preprint! Our latest study uncovers how serotonin precisely controls the “time window” for fear learning, ensuring that our brains link cues (CS) & threats (US) only when it’s adaptive. #Neuroscience #FearLearning
https://t.co/hUhKkW2OPl
biorxiv.org
Fear learning is a critical adaptive mechanism that enables the association of an environmental cue (the conditioned stimulus, CS) with a potential threat (the unconditioned stimulus, US), even when...
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(3/3) Applying Cort1.0 in vivo: We observed stress-induced 😰CORT elevation in the hypothalamus (e.g.,during tail suspension) with Cort1.0 by fiber photometry.Real-time stress hormone readouts, live!
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(2/3) Applying Prog1.0 in vivo: We detected both the maternal behavior-associated🤱 and spontaneous PROG signals ☀️🌙in the hypothalamus with Prog1.0 by fiber photometry.
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(1/3) Excited to introduce our new GRAB sensors for a series of steroid hormones! These tools enable real-time detection of steroid hormone dynamics in vivo🐭🧠.Happy to share these sensors and welcome any feedback!Please contact yulonglilab2018@gmail.com for information.
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(5/5) PGE2-1.0 sensor reveals notable spatiotemporal differences in brain PGE2 dynamics between inflammation and seizure models. This includes distinct kinetics and cortical distributions, contributing to further study of PGE2's roles. #PGE2 #GRAB_Sensors #neuroscience
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(4/5) Applying PGE2-1.0 in vivo: We monitored endogenous PGE2 dynamics with wide-field imaging and captured cortex-wide PGE2 changes during seizure.
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