Michael Krashes
@michael_krashes
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IT'S DANGEROUS TO GO ALONE! TAKE THIS.
Bethesda, MD
Joined September 2016
Thrilled to announce I will be starting a lab at NIH until the next administrative disaster in 2 months time. Reach out if you're interested in uncertainty, disruptive science, reductions in critical workforce that ensure job functionality, hiring restrictions, travel bans & more
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Hooray!! The first major product from the lab is out today @Nature. Small molecules that bind the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.💥 Check it out! 👉 https://t.co/oO21BkoxVQ 🧵👇
nature.com
Nature - Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching...
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How many years of jail time should one get for not including line numbers in manuscript submissions?
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1️⃣ 🥳 Thrilled to share that my postdoc work has finally hit the press! https://t.co/4PIhHQCfEl When we started, we didn’t really know what PVH-MC4R neurons do in obesity. Are they still signaling or “dead” (e.g., does the chronically high leptin alter α-MSH–MC4R signaling)? 🧵👇
nature.com
Scientific Reports - Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons
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'Foraging as an ethological framework for neuroscience' by Laura Grima @LauraGrimaNeuro, Hannah Haberkern, Rishika Mohanta, Mai Morimoto, Adithya Rajagopalan & Emma Scholey https://t.co/o6MxNX3BGO
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In 2016, the first Opto GRC was created to bring together scientists pushing the boundaries of optogenetics research 🧠🌟 Join us to celebrate 10 incredible years of collaboration and discovery—applications for #OptoGRC2026 are now open! Apply now: https://t.co/hy6PyxHELT
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🚨Job Alert!🚨 @NatMetabolism seeks an #Editor to join our team and work in collaboration with @NatureComms🧪🧑💻 If being a #Metabolism Editor is for you, check out our #job posting below and apply before Oct 26th! Locations: US, China. Details below! https://t.co/2LMeCsc5Iq
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An excellent conversation between @iansample and @KevinH_PhD about nutrition science and our book Food Intelligence
theguardian.com
Ian Sample talks to Kevin Hall, a pioneering researcher on ultra-processed foods, about what he wants us all to understand about diet, exercise and weight loss, and why he left the National Institu...
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for anyone interested in the amygdala and risky decision-making, check out our new preprint: https://t.co/sRuIdwv4XX amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
biorxiv.org
Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being...
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New special episode of #DiabetesBio! #TessaCacciottolo
@KristenNadeau
#BethanyCartwright and kids of different ages asking questions that are personal to them! YouTube https://t.co/xsTQzMnAio Apple Podcast https://t.co/fMnaA5ICAX Spotify
open.spotify.com
DiabetesBio · Episode
🚨 New for October, a fresh episode of the #DiabetesBio #podcast! Featuring: ✨ Glucagon Receptor Deficiency & Early-Onset Hepatic Steatosis ✨ Sweet Talk on childhood obesity ✨ Plus! Questions from kids about diabetes and obesity 🎙️Listen at: https://t.co/j4dgLC6GKV
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Excited to announce that I'll be moving to UC Irvine @AnatomyNeurobio next Spring!🌴 Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time. Help spread the word: the UCI lab will be hiring, DM or email (johaono@gmail.com) if interested!
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🚨Please share! We are hiring a post-doc! 🪱 🐀 Job posting: https://t.co/oti6JboNvi Website: https://t.co/f7V0IfQCg1 Trainee info: https://t.co/irnFmp6OYw
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check out the latest work from Ken Ishii examining brain wide responses to opioid and withdrawal states. https://t.co/LI3K16enP6
biorxiv.org
How opioid exposure and withdrawal states shape brain activity at the systems and circuit level remains poorly understood. Here, we use whole-brain, cellular-resolution c-Fos mapping to define...
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Thanks for the invitation to review this topic - sensory signals of nausea - a collaborative effort by lab members!
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Congrats to PNI's Annegret Falkner (@Neurrriot) on earning a 2025 @OneMindOrg Rising Star Award 🌟The funds will support her lab's work on protecting mood and decision-making during hormonal shifts, which may pave the way for targeted hormone treatments 🧠 https://t.co/uVOoRE46Tu
onemind.org
“Protecting mood and decision-making during hormonal shifts—paving the way for next-generation, targeted hormone treatments without the side effects.” Dr. Annegret Falkner’s research maps how social...
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Our latest survey of widely used reagents for GLP-1 receptor detection @Cell_Metabolism continues to find room for improvement. Trust yet verify, together we can all do our part for reagent validation
cell.com
Glucagon-like peptide 1 receptor (GLP-1R) agonists exhibit anti-inflammatory actions, yet the importance of direct immune cell GLP-1R signaling remains uncertain. Although T cells respond to GLP-1,...
Why are we so laser-focused on accurate detection and localization of the authentic GLP-1 receptor? Science should not be an endeavor where sloppiness is tolerated and excused. Suboptimal science causes confusion, needless controversy and erodes the public trust in scientists
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Why are we so laser-focused on accurate detection and localization of the authentic GLP-1 receptor? Science should not be an endeavor where sloppiness is tolerated and excused. Suboptimal science causes confusion, needless controversy and erodes the public trust in scientists
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