Upasana DasAdhikari
@UpasanaDA
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NIDDK K99/R00 fellow-Mucosal Immunology_specializing in organoids modelling of human host microbiota interface_KwonLab@Ragon Institute of MGH, Harvard& MIT
Cambridge, MA
Joined October 2020
Its NOA day!!! truly thrilled to share that I have been awarded the prestigious K99/R00 from NIDDK/NIH to continue studying mucosal immunology. Thank you @kwonlab and @ohyilmaz for your unwavering support. @leah_froehle without you this was not possible
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RT @LabWaggoner: During late gestation, unconventional intraepithelial αβ T cells migrate from the gut to the mammary gland to remodel the….
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RT @humanimmunenews: 🧫 Scientists at @harvardmed found that IL-4 suppressed CD8+ T cell acquisition of an epithelial tissue-resident memory….
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RT @DrSTANtheMAN: NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity @Nature
nature.com
Nature - An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated...
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RT @LabWaggoner: Recent evolution of the developing human intestine affects metabolic and barrier functions @ScienceMagazine @GrayCampLab @….
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RT @LabWaggoner: Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing.https….
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RT @KatajistoLab: Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Pan….
nature.com
Nature Metabolism - Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
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RT @Intestinal_Cell: Scientists show that CREPT/RPRD1B, a protein highly expressed in tumors and essential for crypt-base columnar cell mai….
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RT @DrSTANtheMAN: Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @NatImmunol
nature.com
Nature Immunology - Mitochondrial electron transport chain activity provides ATP, generates superoxide, regulates apoptosis and provides the biosynthetic building blocks for growing cells. Here...
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RT @LabWaggoner: Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors @SciImmunology @MaxKrum….
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RT @BrodinPetter: Weight loss improves health. What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decre….
nature.com
Nature - An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the...
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RT @LabWaggoner: Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells @NatureComms @i_sturmlechner ..
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This would help so much!!! Cant wait to try it.
Our spatial FFPE-ATAC-seq is now published in @NatureComms! With extensive optimizations, it performs well across diverse tissues, unlocking the vast FFPE archive for spatial epigenomics. Big congrats to Pengfei Guo @pengfeo, Yufan Chen, and the team!
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RT @ktguzz: Gut inflammation promotes #microbiota-specific CD4 T cell-mediated neuroinflammation.
nature.com
Nature - Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.
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RT @JCI_insight: Tissue-resident memory T cells persist long-term in the skin and gut where they can activate upon infection, but their tem….
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Food for next brainstorming session.
See why the ovary − often reduced to its reproductive role − menopause, age and estrogen affect a woman’s health throughout her body and lifetime.
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RT @iannaconelab: 1/ 🚨 Hot off the press in @NatImmunol: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the….
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RT @LukasValihrach: Tracing colorectal malignancy transformation from cell to tissue scale👏.
biorxiv.org
The transformation of normal intestinal epithelium into colorectal cancer (CRC) involves coordinated changes across molecular, cellular, and architectural scales; yet, how these layers integrate...
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RT @LabWaggoner: Review @ImmunityCP @calico.More TOR: The expanding role of mTOR in regulating immune responses.htt….
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RT @ImmunityCP: Online now: Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells https:….
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RT @DrSTANtheMAN: Endoplasmic reticulum stress responses in anticancer immunity @JCubRuiz @NatureRevCancer
nature.com
Nature Reviews Cancer - The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress...
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