🔎 STK3 was identified as a transcriptional target of YAP1, leading to enhanced DNA repair ability and #stemness acquisition during #GastricCancer progression, report Dr. Wei Kang and colleagues. 📖 Read the findings here:

This work in @NatureComms led by Dr. Haiyang Chen's team substantiates the role of α-lipoic acid in inhibiting human #IntestinalStemCell aging and presents a potential therapeutic approach for managing age-related human intestinal diseases. 💡 Learn more:

Huge congratulations to Dr. @john_damianosMD and co-authors on their new release in @Gut_BMJ! 👏 . Their #Review explores the evidence for increased permeability in #CeliacDisease and the underlying mechanisms.

Investigators showed that PARD6B regulates tumor progression in colorectal cancer (CRC). Its expression in CRC correlates with DNA copy number amplification, including enhancer regions. 🧬. Learn more:

Scientists summarize the function of p53 and characterize its mutation in colorectal cancer (#CRC), emphasizing the influence of p53 mutation in the pathogenesis of CRC.

Can't get enough #IntestinalCell research? . Subscribe to our regular newsletter and never miss another update! . 💡

The latest in #ColorectalCancer (CRC) research! ⚛️ . @firstascentbio announced a new collaboration with national nonprofit @FightCRC to launch a prospective feasibility study aimed at transforming CRC treatment. 📰 Check out the release:

Hello? Calling all scientists. 📞. Now is your chance to find out which #organoid you are with a @STEMCELLTech personality quiz! . Share your results and pass it on to your colleagues.

This #ClinicalTrial in @sigtrans_sttt assessed the safety and efficacy of garsorasib with or without cetuximab in KRAS G12C-mutated #ColorectalCancer. Read about their findings:

Researchers including Drs. Christophe Altier and Joseph Schlessinger identify an ALKAL2/ALK mechanism by which inflammation-responsive nociceptive neurons contribute to #ColorectalCancer progression. | @PNASNews . 📝

Findings from this paper suggest that NUCKS1 contributes to #ColorectalCancer (CRC) invasion and metastasis by stabilizing HDAC2 and activating AKT, highlighting NUCKS1 and HDAC2 as potential therapeutic targets for CRC. 🎯 .

Findings from this @iScience_CP study show that BRAFV600E maintains aberrant DNA and histone methylation patterns in advanced #ColonCancer, likely preserving the transformed phenotype. 🔎 Get the full story here:

🔑 Dr. Patrizia Cammareri (@weepatri) and investigators identify the chromatin-remodeling enzyme ATRX as a key regulator of colonic lineage fidelity and metastasis in colorectal cancer!. @Nature |

🔬 Scientists introduce the high-definition Visium spatial transcriptomic technology and investigate formalin-fixed paraffin-embedded human colorectal cancer samples. @NatureGenet |

📖 The authors elucidate the functional significance of ferroptosis in the pathogenesis of gastric cancer and review the dysregulated metabolic pathways associated with this cell death process. 🔗

🩺 This trial conducted by Dr. Elena Elez and scientists at @vallhebron showed significantly longer PFS and overall survival with first-line treatment with EC+mFOLFOX6 than with standard care among patients with BRAF V600E–mutated metastatic CRC. @NEJM |

💡 Researchers demonstrated that eukaryotic translation initiation factor 5A is indispensable for maintaining intestinal epithelial homeostasis by regulating mitochondrial translation. Learn more!🔗

This #ClinicalTrial published in @NEJM showed significantly longer PFS and OS with first-line treatment with EC+mFOLFOX6 than with standard care among patients with BRAF V600E–mutated metastatic #ColorectalCancer. 📃

The conference season is in full swing! How did you decide which ones to attend?. 📖 Read this handy guide from @STEMCELLTech to choose where to concentrate your efforts next time. #PhDLife.

Drs. Beatrice Greco, Monica Casucci, and Rita El Khoury led this work supporting systemic delivery of CDH17 #CAR-T cells as a safe and effective approach to treat #CRC liver metastases and pave the way for a Phase 1/2 clinical trial. 🩺. | @ScienceTM