Stay current on colorectal cancer, IBD, and #colitis research. 💡 Intestinal Cell News delivers weekly #intestinal research highlights straight to your inbox. 🔔 Subscribe for free: https://t.co/56Pvfh6Hcg

🚦 This study identifies key regulators of ferroptosis at distinct pathological stages, thereby providing insight into novel strategies for the management of precancerous lesion‑related diseases and gastric cancer. 🔗 https://t.co/eilJb1XWwj

🔎 Scientists identify a function for the microprotein FXYD domain-containing transport regulator 3 in goblet cells in regulating mucus layer formation to maintain intestinal homeostasis. @CellReports | https://t.co/OoQZXsV0nu

🥳 We’re excited to announce the winners of our lab coat giveaway! 🥼 Congratulations to Olivia Reyes-Castro, Elizaveta Valovatsky, and Juliana Candelaria on your new lab coats! Thank you to everyone who entered and all the amazing scientists out there driving science forward!

Scientists integrated scRNA-seq of primary tumors and matched metastatic lymph nodes from six #GastricCancer patients to identify a metastatic epithelial subpopulation characterized by EGR4 overexpression. 🔎 Discover their results: https://t.co/JUi3yV303G

This study reports that L-glutamate promotes mitochondrial biogenesis and intestinal stem cell (ISC) expansion by activating the EGFR–MEK–ERK–mTFB2 axis, highlighting a nutrient-sensing mechanism that couples energy availability to ISC function. 🔗 https://t.co/uUm9QyhIX1

📊 Findings detailed in this study suggest that the CBS/H2S axis contributes to the regulation of intestinal stem cell homeostasis and represents a potential target for radiation protection, mediated through the intervention of non-epithelial cells. https://t.co/pdEbsBiLmz

🔒 Problem: The apical surface of your hPSC-derived intestinal #organoids is hard to access. 🔑 Solution: @STEMCELLTech's protocol: https://t.co/ywj90oWxeE

🧪 Researchers show that JMJD3 is highly expressed in both #GastricCancer tissues and patient-derived chemotherapy-resistant xenograft models and contributes to increased malignancy and chemoresistance. @cddpress | https://t.co/WhKmOimojg

😲 Secreted proteases are major actors of intercellular communication in the gut. The complex interplay among proteases, their substrate, and their inhibitors must be considered to fully comprehend gut physiology and pathophysiology. @NatRevGastroHep | https://t.co/mg6YmGLUHL

💡 DAT promoted mTORC1-dependent activation and proliferation of intestinal stem cells, with concomitant engagement of the innate immune receptor STING required to mitigate metabolic stress. @naturecomms | https://t.co/e6uTzkkpcF

Dr. Jeanne Tie's team at @PeterMacCC led a multicenter, randomized, Phase II/III trial, where patients with stage III colon cancer underwent ctDNA testing 5–6 weeks after surgery and were assigned to ctDNA-guided or standard management. @NatureMedicine | https://t.co/r9JEyuJJ1m

The complex topography of the intestinal crypt/villus structure makes functional intestine modeling challenging. Scientists present engineered decellularized matrix hydrogels with crypt–villus topography for forming functional intestinal epithelium. 👉 https://t.co/NTmmRFD7Ij

Scientists describe the novel function of USP13 as a crucial regulator of necroptosis. USP13 interacts with cellular IAP2 (cIAP2), stabilizing cIAP2 proteins in #ColorectalCancer cells. 🧫 https://t.co/kFuDRNjmwK

Hello? Calling all scientists... 📞 Now is your chance to find out which #organoid you are with a @STEMCELLTech personality quiz! Share your results and pass it on to your colleagues. https://t.co/yP6QTPmxMS

Using a computational framework, cSplotch, scientists identify cellular and molecular gradients along the adult colonic tract and across the main crypt axis and multicellular programs associated with aging in the large intestine. 📖 https://t.co/SChttO6vup

🔥 New in @Nature! .@genentech scientists and their collaborators show that the Escherichia coli ubiquitin ligase NleL is an inhibitor of #intestinal epithelial cell extrusion, targeting caspase-4, ROCK1 and ROCK2 for proteasomal degradation. 🔓 https://t.co/aQTbjGYJLH

This @cddpress study showed that USP14 promotes the proliferation, migration, invasion, and tumor growth of #GastricCancer cells. 🔓 Read the full study: https://t.co/ROLYF5wGc8

Scientists establish CLK2 as a critical inhibitor of ferroptosis via the KEAP1/NRF2/HMOX1 and p53/SLC7A11 axes, supporting its potential as a therapeutic target for #colorectal cancer. 🔗 More in @CR_AACR: https://t.co/wbjoS812ds

💌 Simplify your job search with Science News by @STEMCELLTech! Our website and regular newsletters keep scientists current with the latest peer-reviewed research, reviews, and job opportunities. 🔗 Learn more: https://t.co/DpedtOUfPl

📖 This review examines the design, fabrication, and application of biomimetic nanocarriers specifically for colorectal cancer. It further explores the application of these nanocarriers in chemotherapy, #immunotherapy, gene therapy, and more! 🔗 https://t.co/bdGkhNQgxq