Takaku_lab
@TakakuLab
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Associate Professor at UND School of Medicine and Health Sciences, Gene and chromatin regulation in cancer
Grand Forks, ND
Joined April 2019
Today in @NatureBiotech, we report engineered DNA recombinases with up to 53% integration efficiency and 97% genome-wide specificity at an endogenous human locus, inserting large DNA cargoes up to 12 kb for stable expression in primary human T cells, stem cells, and non-dividing
Site-specific DNA insertion into the human genome with engineered recombinases https://t.co/4ICZ9ljmJz
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論文が出ました！長寿遺伝子SIR2の加齢に伴う機能低下の謎が解けました。実はSir2の量が減るというより、その存在場所が加齢に伴い変化していたのです。 Yamamuro, Y. Uneme, Y., Li, C., Inada, T., and Konbayashi, T. Nucleic Acid Res 2025 Oct 29;53(20):gkaf923. doi: 10.1093/nar/gkaf923
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Nice paper in @ScienceMagazine apparently showing for the first time that DNA breaks leave lasting epigenetic scars Excitingly, it’s consistent with The Information Theory of Aging & our discovery of this same phenomenon in 1997, 1999, 2008 & 2023 🤣👏🧵 https://t.co/kDmqCO8b4J
science.org
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is...
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CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci https://t.co/5VtEnCmKEB
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雄マウスからの機能的な卵母細胞の生成に関する 林 克彦 教授らの@Nature #論文 Generation of functional oocytes from male mice in vitro https://t.co/4deaNjMi39 論文： https://t.co/iYQJi0X3PL
@UOsaka_ja @WPI_PRIMe
Sex cells made from scratch could revolutionize human reproduction https://t.co/Ng3Q2OVuld
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🎯 We show GR-LBD ability to bind Bile Acids to a new unidentified, highly conserved, surface-exposed cavity. Bile acids affect GR turnover & self-assembly in living cells, modulate GR transcriptional activity revealing a new way of GR regulation to design drugs with novel MOA 🧩
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This is what the last five years have been about! Incredibly proud to share our new paper in Nature Genetics: “Transcription Factor Switching Drives Subtype Specific Pancreatic Cancer.” Thank you @JCarrollLab @PancreaticCanUK @CRUK_CI
https://t.co/tu5do3uRE7
nature.com
Nature Genetics - Pancreatic cancer progression is driven by a switch from HNF4G-driven transcriptional activity in primary disease to FOXA1-mediated transcription in the metastatic setting.
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クジラの長寿の謎に迫る ホッキョククジラは体の大きさにも関わらず、がんが少ないらしい。このメカニズムとしてDNA修復能力を高めていることを発見(ゾウなどとは異なるらしい)。特にCIRBPという因子が重要で、この強制発現でハエでも長寿命に。 https://t.co/m8jiZZeFvp
nature.com
Nature - Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.
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遠隔臓器によるがん進行制御 非アルコール性脂肪性肝疾患(NAFLD)が乳がんの発症と進行を促進する可能性を発見。NAFLDの肝臓から放出されるエクソソームが乳房脂肪細胞で腫瘍微小環境を変化させるらしい。バイオマーカーになる可能性も https://t.co/fsa28vJRMD
cell.com
Li et al. demonstrate that fatty livers foster a favorable metabolic landscape for breast cancer via adipocyte-oriented exosomes. These exosomes display tropism to mammary adipocytes through the...
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No se lo pierdan!!! Minisimposio de epigenética en México. Un lineup increíble de ponentes!!! 18 y 19 de Noviembre en el IFC les esperamos (registro en el QR anexo).
🗓⏰📍Minisiposio por 25 años de Epigenética en México, martes 18 y miércoles 19 de noviembre de 9:30 a 17:00 hrs., auditorio Antonio Peña. Responde este formulario para acudir: https://t.co/MRN7Q9L1Ww Algunas charlas se van a transmitir por YouTube: https://t.co/ynBgRcTkrh
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🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work @PabloFuentesP Gordon Hager @AlbaJimP1 @Andrea_AlegreM @aguslafuent #TomJohnson @PeraltaMNuria @PresmanLab #JFRecio #JaimeRubio @BQBiomedMolUB 🥳🚀
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TP53, RB1, CDKN2Aなどが失活し、G1-Sチェックポイントが働かない腫瘍細胞に対して、サイクリンA/Bの基質結合ドメインを標的とした小分子を開発、腫瘍抑制に効果があったという論文。Nature。 https://t.co/D9PCrXbnj5
nature.com
Nature - Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.
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Very excited to co-organize with @kjarmache the 2026 Keystone Symposium, Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities (March 2–5 | Geneva, Switzerland)!👉 https://t.co/cZ8Zm5YsL4
#KSEpigenetics26
keystonesymposia.org
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
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コヒーシンという髪留めのような輪っかのタンパク質が2本の染色体を束ねていますが、DNAをコピー(複製)するとき邪魔じゃない？ぶつかるんじゃない？と言われていた物に対して、「実は輪っかの中をコピー機が通れます。しかもコピー機の部品(DNAポリメラーゼαとε)がそれを助けてます」。という内容。
cell.com
Glaser et al. use single-molecule imaging to visualize encounters between the DNA-replication machinery and cohesin rings in real time. They see replisomes passing through cohesin rings—a simple...
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Online Now: Productive mRNA chromatin escape is promoted by PRMT5 activity https://t.co/HaP7bCM4pg
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🚀 Big update to iDEP — our popular app for RNA-seq and omics data analysis. Visualize, analyze, & unveil pathways. In minutes! What’s new 1. Updated annotation of 13,000 genomes 2. Cleaner, faster UI with improved docs 3. Import external fold-change & p-value tables, then run
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A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness | Science
science.org
Understanding how genetic variation translates into complex phenotypes remains a fundamental challenge. In this work, we address this by mapping genome-to-proteome relationships in 800 progeny of a...
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ハダカデバネズミは非常に長寿でがん耐性です。細胞質DNAを感知し免疫に関与するcGASは、ヒトではDNA修復を阻害しますが、ハダカデバネズミのcGASは変異を有しており、DNA修復を促進することで老化を遅らせ、寿命を延ばすことを明らかにした論文がScience誌に発表されました。 https://t.co/67cMNFmjH5
science.org
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that...
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Our new paper was published on Aging Cell last week! Single-cell multi-omics of the young and aged mouse hippocampus revealed epigenomic priming of developmental and activity-responsive genes in neurons and Bach2 reduction may drive chromatin activation. https://t.co/utM8IUo2Sw
onlinelibrary.wiley.com
Single-nucleus multiome sequencing of hippocampus reveals aging-dependent changes in gene expression and chromatin accessibility. Chromatin alterations in synaptic genes often occur without corresp...
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Excited to share our new paper in @MolecularCell! Congratulation to the transcription team @Franburgos_ AlexTong, ChenLi, @CesarDiazC and our fantastic collaborators @ReinbergDanny & Kaplan labs! @BustamanteLab
#Transcription #Chromatin #SingleMolecule #OpticalTweezers #FACT
Online Now: FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate
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