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David Sinclair Profile
David Sinclair

@davidasinclair

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Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️

Boston
Joined March 2012
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@davidasinclair
David Sinclair
17 days
Lifting weights isn't vanity, it’s life insurance. Strength training cuts risks of all‑cause death by ~17%.
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@davidasinclair
David Sinclair
3 hours
RT @Dr_Singularity: If we can’t make more young people, we need to stay young longer - aging reversal is the key. Aging reversal R&D must….
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@nysdmv
NYS DMV
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Speeding causes nearly one-third of all traffic deaths. It’s no game. Learn about the dangers of driving too fast.
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@davidasinclair
David Sinclair
3 hours
RT @Dr_Singularity: The era of reversing aging at the cellular level is beginning. A biotech company called Life Biosciences is working on….
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@davidasinclair
David Sinclair
7 hours
Belmonte said that Altos Labs wants to apply the partial reprogramming strategy to rejuvenate organs that are currently not suitable for transplantation.
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@davidasinclair
David Sinclair
7 hours
Partial reprogramming was the subject of multiple talks at the meeting, both scientific and translational. Juan Carlos Izpisua Belmonte at Altos Labs, described his team’s work on using partial reprogramming to prevent what they call “mesenchymal drift.”.
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@DJTFentanylFree
Make America Fentanyl Free
13 hours
Make America Fentanyl Free supports President Trump’s efforts to end the fentanyl crisis.
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@davidasinclair
David Sinclair
7 hours
There are currently “no regenerative therapeutics for glaucoma and no therapeutics at all for NAION,” Life Biosciences chief scientific officer Sharon Rosenzweig-Lipson told the audience at the ARDD meeting.
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@davidasinclair
David Sinclair
7 hours
The underlying technology was licensed by Harvard Med School to Life Biosciences Inc., which has been developing it for open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy (NAION), a form of sudden-onset vision loss.
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@davidasinclair
David Sinclair
7 hours
Researchers demonstrated that expressing OSK in vivo in retinal ganglion cells restored older cells to a more youthful state in terms of their methylation patterns, promoted axon regeneration after injury, and reversed age-related vision loss and vision loss due to glaucoma.
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@davidasinclair
David Sinclair
7 hours
The 2020 discovery that expressing only three of the Yamanaka factors �� Oct, Sox and Klf (OSK) – could rejuvenate cells without returning them to a pluripotent state turned in vivo reprogramming into a clinical possibility.
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@davidasinclair
David Sinclair
7 hours
New @BioWorld article -.Life Bio is developing epigenetic reprogramming technology for liver disease, not just optic neuropathies. ER-100 will enter trials 2026, making it the first use of partial epigenetic reprogramming in humans
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bioworld.com
At the 12th Aging Research & Drug Discovery (ARDD) Meeting, which is being held this week in Copenhagen, Life Biosciences Inc. announced that it is developing its partial epigenetic reprogramming...
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@davidasinclair
David Sinclair
19 hours
Ultra-processed food intake is associated with higher mortality. The strong-willed resist the easy path.
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@CelsiusOfficial
CELSIUS Energy Drink
16 hours
This is more than just four quarters. It’s every tailgate, every chant, every moment. It’s fuel that goes beyond the field. This is CELSIUS!.LIVE. FIT. GO.
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@davidasinclair
David Sinclair
2 days
Well said 💯.
@jpsenescence
João Pedro de Magalhães
4 days
If aging is a software problem, as @davidasinclair and I advocate, it will be much easier to reverse than if aging is the result of passive damage accumulation. Despite its challenges, reprogramming cells for youthfulness, is the most prosiming approach to anti-aging therapy.
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@davidasinclair
David Sinclair
2 days
I'm optimistic: so far the epigenetic rejuvenation technology headed to human trials in January regenerates tissues in general, no matter which organ or how it's damaged, whether by injury, disease or time.
@Toil_Company
Toil
2 days
@davidasinclair @lifebiosciences Can it help with liver cirrhosis?.
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@davidasinclair
David Sinclair
2 days
@davidasinclair
David Sinclair
2 days
NEWS: @lifebiosciences reports new drug candidate ER-300 improves liver health, while ER-100 restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements. Human trials are on track for January. It’s happening. 🧵
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@davidasinclair
David Sinclair
2 days
Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board and entire R&D team led by Sharon Rosenzweig-Lipson
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@CPAC
CPAC
15 days
Zohran Mamdani: He votes for activists, not you
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@davidasinclair
David Sinclair
2 days
This is an exciting moment for @lifebiosciences and for all of us who believe in the potential of cellular rejuvenation
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@davidasinclair
David Sinclair
2 days
Epigenetic reprogramming in vivo is now shown to work across systems, from liver to eye, and likely many more.
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@davidasinclair
David Sinclair
2 days
With ER-100 on track for human trials in Q1 2026, this program is moving quickly toward patients 💉👁️
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@davidasinclair
David Sinclair
2 days
This adds to earlier data showing clear functional benefits in the eye. They also beautifully match the mouse data we published in Nature (2020), in fact they are even more dramatic in their reversal of DNA methylation 😲
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nature.com
Nature - Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision...
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@davidasinclair
David Sinclair
2 days
In ocular diseases, ER-100, the drug candidate from from our lab and first in development @lifebiosciences, showed a remarkable ability to restore healthy DNA methylation patterns and boost neuronal regeneration processes in a nonhuman primate model
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@keyOfIsis
Divine Disciple
7 days
New (old) age mediations.
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@davidasinclair
David Sinclair
2 days
These results add to the weight of evidence that reprogramming is not just for age-reversal, it can be used to treat diseases that affect millions worldwide and with few effective treatments
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