
David Sinclair
@davidasinclair
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Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Boston
Joined March 2012
Lifting weights isn't vanity, it’s life insurance. Strength training cuts risks of all‑cause death by ~17%.
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RT @Dr_Singularity: If we can’t make more young people, we need to stay young longer - aging reversal is the key. Aging reversal R&D must….
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RT @Dr_Singularity: The era of reversing aging at the cellular level is beginning. A biotech company called Life Biosciences is working on….
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New @BioWorld article -.Life Bio is developing epigenetic reprogramming technology for liver disease, not just optic neuropathies. ER-100 will enter trials 2026, making it the first use of partial epigenetic reprogramming in humans
bioworld.com
At the 12th Aging Research & Drug Discovery (ARDD) Meeting, which is being held this week in Copenhagen, Life Biosciences Inc. announced that it is developing its partial epigenetic reprogramming...
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Well said 💯.
If aging is a software problem, as @davidasinclair and I advocate, it will be much easier to reverse than if aging is the result of passive damage accumulation. Despite its challenges, reprogramming cells for youthfulness, is the most prosiming approach to anti-aging therapy.
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I'm optimistic: so far the epigenetic rejuvenation technology headed to human trials in January regenerates tissues in general, no matter which organ or how it's damaged, whether by injury, disease or time.
@davidasinclair @lifebiosciences Can it help with liver cirrhosis?.
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NEWS: @lifebiosciences reports new drug candidate ER-300 improves liver health, while ER-100 restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements. Human trials are on track for January. It’s happening. 🧵
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This is an exciting moment for @lifebiosciences and for all of us who believe in the potential of cellular rejuvenation
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This adds to earlier data showing clear functional benefits in the eye. They also beautifully match the mouse data we published in Nature (2020), in fact they are even more dramatic in their reversal of DNA methylation 😲
nature.com
Nature - Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision...
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In ocular diseases, ER-100, the drug candidate from from our lab and first in development @lifebiosciences, showed a remarkable ability to restore healthy DNA methylation patterns and boost neuronal regeneration processes in a nonhuman primate model
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