David Sinclair
@davidasinclair
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Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Joined March 2012
NEW STUDY: People who consistently do vigorous exercise have slower rates of epigenetic aging compared to those who don't. Light to medium activities don't cut it
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For those who wanted a world without vaccines, witness the world without one vaccine.
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Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19. What follows is a thread of information, my interpretation, links to sources & predictions. Let's start with what you need to know. #coronavirus #COVIDー19.
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Dude, in that photo I was 35 🤦♂️.
The exact longevity supplements that Harvard scientist Dr. David Sinclair uses. He's 54 but literally looks 35. -An overview of 13 supplements/drugs.-Their underlying logic.-Recommended dosages. (Save this thread for reference). THREAD🧵
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This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases 14/17
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Disagree @elonmusk. Studies of identical twins show longevity is 80-90% epigenetic, meaning it can be changed by lifestyle, for the same reason a queen bee raised on royal jelly can live 10 times longer than a genetically identical worker 🐝.
@paulg Our lifespan is programmed into our genes, just like it is for fruit flies or pets. Fruit are already vegan & even if they do yoga every day & take every supplement, they still only live 50 days.
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Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏.
Omega-3 supplements slow biological ageing
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Delighted to share with you our latest paper. Here, we test the hypothesis that aging may be driven by DNA damage-induced changes to the epigenome. Mightbe due to a glitch in the software of the body that causes it to malfunction, which can be fixed with a reboot?👇 1/
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New paper provides evidence that black holes are the origin of dark energy & the expansion of the universe. Yeah, that’s a big deal
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Grateful to share our latest publication: We’ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it’s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1/17
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Factors that accelerate epigenetic aging:.1. Smoking (worst).2. Alcohol intake.3. Waist size .4. Body fat .5. CRP (inflammation).6. Triglycerides.7. Childhood obesity .8. Type 2 diabetes.(Alcohol is turning out to be more toxic than we thought. Sorry)
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Yes, hair greying is reversible. Working on it.
Since reporting that human hair greying is reversible, linked to life stress, and associated changes in mitochondrial biology, we have received >300 testimonials confirming the observations. A recent note (shared with permission):."Around the same time
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Just used it to solve a key scientific problem. It is the smartest 👏.
This is it: The world’s smartest AI, Grok 3, now available for free (until our servers melt). Try Grok 3 now: X Premium+ and SuperGrok users will have increased access to Grok 3, in addition to early access to advanced features like Voice Mode
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Study of 135K people finds high carb diets have highest mortality & high fat the lowest. Total fat intake was not associated with heart disease 😳 Authors: “Global dietary guidelines should be reconsidered.”
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What science says about maximizing life:.1. Eat less often. 2. Avoid sugar & high GI foods. Eat stressed plants. 3. Do hip-hinge exercises, stretch, pant a few times a week. 4. Block blue light. Sleep well. 5. Calm your mind, never lie, don't hate. 6. Have close friends & pets.✌️.
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Age reversal works in primates to restore vision. Announced by my collaborator Dr. Bruce Ksander & @lifebiosciences. Next up: age reversal in humans. How’s that @elonmusk? 🚀.1/10…
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Why would I want 50 more years of life? Because I’m finally getting the hang of it.
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Now we understand a tiny bit what it’s like living in a pre-vaccine world. Salk’s inactivated polio vaccine launched on a Friday (Mar. 12, 1954) changes the world by reducing cases of childhood paralysis from 350,000/year in 1988 to 33 in 2018. #FridayMotivation #FunFactFriday
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In the future, rather than an annual checkup, our health will be monitored a million times a second and the alternative will seem medieval.
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Aging and cancer have the same root cause: cells forget how to behave. Aging is reversible. Maybe cancer is too.
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Accidentally hit and crushed 2 doors of a parked car. Left my phone #. Owner's response made my day
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Working on it.
I hate that every awesome thing comes to an end. I wish it would last forever.
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Scientists conclude that Alzheimer's a "natural part of human brain aging." Sorry folks. Stop the research. Alzheimer's is no longer a disease.
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New approach to age reversal @elonmusk: Life is information. When corrupted, we age & die. Found a backup copy (cf Shannon). With genes & chemicals, we reboot the body. Works in monkeys to restore vision. Humans next.
@davidasinclair Ok, so what exactly is it?.
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Took me 50 years and a lot of getting screwed to come to terms with the fact that there isn’t good in everyone.
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This will soon seem normal.
A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal cord injury.
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We’re trained to think that the cellular changes caused by aging are irreversible. I’ve seen no evidence for that.
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I have come to realize the key to success in life is not brains or luck, it's tenacity.
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Announcing to the team we received acceptance at a top scientific journal of a 13 year study to test The Information Theory of Aging… 1/n #harvard
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A new paper has lit up the longevity field. Removal of interleukin-11 improves health and extends mouse lifespan by up to 24%. Human therapies are being developed 🧵
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If you’re not shocked by the thought of who you were 10 years ago, you’re not growing.
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Here’s a list of all major sources of DNA damage in our daily lives & how to avoid them. 🧵
@davidasinclair But what is causing this damage?.
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Your aging clock ticks over every day. Science says the earlier you change your lifestyle to slow aging, the healthier and more vibrant you will be and will remain. Why wait?.
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Never hire people based on skills. Look for passion & raw talent. These cannot be taught.
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New study finds immune T cells engineered to kill zombie senescent cells 🧟♀️ can reverse key aspects of aging in mice 🐁 including metabolic & physical decline. Imagine a single treatment that protects from aging, for life…see thread
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The body's self-cleaning mechanism that recycles old proteins requires spermidine, a remarkable molecule that prevents hair loss in mice and extends the lifespan of every species tested. So what is spermidine and does it work in humans? 🧵.
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If aliens saw us speaking to people overseas on pocket devices, speeding in self-driving cars, and flying in giant planes, they’d be shocked that aging still hadn’t been solved.
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Treatments that seem to work are chloroquine (a cheap malarial drug), Gilliad's remdesivir with interferon-beta (in clinical trials from COV-19), plasma from recovered patients, and a steroid (methylprednisilone). Doctors in US are now using remdesivir off-label. .
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Recipe to feel great each day:.•Don’t finish big meals.•Avoid sugary foods.•Stretch at every chance.•Walk whenever possible.•Get a standing desk.•Optimize sleep.•Be kind.
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Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? 1/n
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Matcha, or Japanese ceremonial green tea, is one of the world’s healthiest drinks. Not because of antioxidants but survival molecules that Camillia sinensis makes when grown in the shade. When we ingest them, they boost our survival enzymes to fight aging & disease 💪 1/7
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A nightmare substance would be one that, in low doses, protects the heart, but is toxic to the brain. According to research in the last few years, that substance is alcohol… 🍷
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Paradigm shifts:.1910s - Flight .1930s - Antibiotics .1950s - Space.1970s - PCs.1980s - Internet.1990s - Genomics.2000s - Smartphones .2010s - Energy.2020s - Age reversal.
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NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy. Huh? Is fasting still worth it? . 🧵
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If aging were optional, would you choose to stay young?.
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Dr. Eric Kandel, the energetic neuroscientist and Nobel winner, is retiring at 92. It remains unclear why he chose early retirement
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Each day, if you can, set aside 10 minutes for quiet time, breathing deeply, appreciating all you have. If you’re just too busy, do it for 30 minutes.
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Life never gets easier, no matter how long you live. All you can do is get better at it.
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@elonmusk @lexfridman It is a human right to choose when you die. This will become a reality.
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Human trials with longevity molecules that directly activate Sirtuins will begin again in 6 months, 13 years after bad science from Pfizer almost killed my lab and the entire field. Onward! 🙏🚀 .
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The 13 year study often took me away from you. Now it’s finally done. Thank you for you patience. I love you ❤️
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A 50-year-long study of twins finds exercise may not be as important for longevity as we think . A thread. 🧵
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It is incontrovertible that skipping meals while maintaining adequate nutrition is not only good for you but will make you live longer.
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1. Everyone has a right to lifespan extending medicines.2. Lifespan extension must be optional .3. Lifespan extension must be a consequence of improved health .4. No one should be subjected to biological age discrimination .5. Lifespan extension must be available to other species.
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Should we reverse aging? Age reversal is coming @elonmusk. That’s like asking: Should we develop AI? Build reusable rockets? Go electric? Purely academic questions, amusing to those who are making it happen 🚀 @waitbutwhy @lexfridman.
@waitbutwhy The precision of our biological clock across trillions of cells is incredible. One never sees someone with an old left arm, but a young right arm. Aging can obviously be fixed. The real question is whether it should be.
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The new science of aging says the process starts ticking even before you’re 20. So don’t wait to live a lifestyle that slows aging. Act now.
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Amazing. ChatGPT-o1 has self-reasoning and now outperforms PhD experts. Can’t wait to have an AI-powered humanoid robot to stack my dishwasher.
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Blood, HbA1c, and chloroquine.CoV2 mutations.Symptoms .Susceptibility/Risk.Fatality.Therapies.Remdesivir.☮️.
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Our next installment of epigenetic rejuvenation via age reversal is out: 2 months of OSK gene therapy in mice with glaucoma fully restores their vision, with no evidence of side-effects, even after prolonged use. Congrats to Bruce Ksander, @YuanchengLu, and the entire team 👏🏻🙏
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One meal a day (OMAD) is increasingly popular. Even when eating the same number of total calories, those on OMAD burned more fat, had lower blood glucose, and experienced no reduction in lean muscle mass, aerobic fitness or strength 💪
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You’re alive. 93% of humans are not. Have a great day.
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Healthspan is the new wealth. Invest early, compound for life.
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Production is in full swing, separating fact from fiction on my limited scientific podcast series on health & longevity:.1. Skipping meals/fasting .2. Infrared saunas/cryotherapy .3. Hyperbaric oxygen chambers .4. Peptides.5. Senolytics.6. Metformin/rapamyin.7. NAD, NR, NMN.
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Limiting sugar before age 3 protects against diseases later in life
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We all have an internal life clock. Each day, we make decisions that cause the clock to tick over much faster or slower, depending on when & how much we eat, sleep & exercise. It’s hard to be perfect but it helps to ask: “What would my future self want me to do today?”.
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A loss of smell is emerging as a symptom of #COVID-19. Might be due to the silencing of a gene called sonic hedgehog and a loss of signaling factors that cause stem cells to divide in the tongue and nose. Alpha-lipoic acid seems to help. Here's the paper:👃
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Over-exercising induces irreversible liver fibrosis (who knew?) by inducing the secretion of damaging vesicles from muscles called “lactate bodies” @Cell_Metabolism
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New study: Gut bacteria convert choline from RED MEAT into TMA, which becomes TMAO, a chemical that may cause cardiovascular disease. Berberine, a natural molecule that lowers blood sugar (like metformin does) also inhibits production of TMAO 💪
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There’s nothing better than realizing how easy it is to slow the pace of aging.
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People who work longer, live longer. Find what you love. Do that. Live longer! Win win!!.
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Dad’s arrived in Boston from Australia for his 85th 🎂 I suggested a planking endurance competition. I’ve been practicing & he’d be tired from travel, giving me a shot: . Me: 2 minutes 30! Your turn. Dad, after 4 minutes: I’m bored, can I stop now?. Me: Fine 😳❤️
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Article on how DNA repair alters the epigenome to erase youthful information and drive aging, and how to reset the system #informationtheoryofaging
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As I approach 50, I appreciate the people who have reached out to tell me that I look younger than my age. What's my secret? Diet? Exercise? Longevity molecules?.Nope: Old photos.
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Some containers release as many as 4.22 million microplastic and 2.11 billion nanoplastic particles within 3 min of microwave heating. Refrigeration for over six months can also release billions of microplastics and nanoplastics 😮.
Assessing the Release of Microplastics and Nanoplastics from Plastic Containers and Reusable Food Pouches: Implications for Human Health. @ACSPublications
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. But there was also a naysayer in the same issue of the @nytimes. Albert Sabin, Salk’s competitor, said the research was going too fast, proving that even the greatest breakthroughs have their critics. #FridayMotivation #science #FunFactFriday
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Most cancers require high glucose to proliferate and survive. In 🐭, a low sugar, high protein diet reduced tumor size & death rates, indicating that lowering blood sugar levels & increasing protein may be a way to prevent & treat cancer
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If you think life’s too short, do something about it.
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When you eat sugar, some of it attaches to your body’s proteins, an aging process called glycation. New study says oral resveratrol protects against glycation & kidney damage in a sugar-induced aging mouse model. Me: still taking resveratrol in yogurt
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@elonmusk @PeterDiamandis Hey @elonmusk, @PeterDiamandis, my lab will be publishing new age reversal results later today. Stay tuned 🚀.
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Unless you want to still feel your best after 65.
Eat the food that makes you feel your best. Everything else is a distraction
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So excited about my 8-part podcast series. Will dedicate an entire show separating fact from fiction about the use of NR, NMN & NAD IVs to slow aging 💊💉📢 #podcastlife #aging #longevity Useful paper:
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Healthy people who reduced their caloric intake 25% became epigenetically younger, based on the DunedinPACE of aging clock, and the effects were seen in a year
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If you turned today 100 and felt like you do now, would you want to die? Of course not. So asking “How long do you want to live” is pointless. The right question is “When do you want to get frail and sick.” . What’s your answer?.
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Amazing! New paper shows biological age rapidly increases during stress & reverses when the stress is relieved. That’s a relief 😅 .
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Given financial support, scientists can cure any disease.
Blind children see for the First Time thanks to a revolutionary Gene Therapy. A groundbreaking gene therapy has restored sight in four young children born with severe blindness due to a rare genetic deficiency. "Scientists at UCL and Moorfields Eye Hospital successfully injected
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Stay calm. Always. Getting rescued from a stuck elevator in a 50 story NYC hotel at 5am & missing my ✈️ should have raised my heart rate. No way! It’s still going to be a great day!.
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. the virus could more easily disrupt the heme in red blood cells. If so, the virus is very smart: it destroys the lung so patients can't take up oxygen AND reduces the body's ability to carry oxygen. (For this & other reasons, you should eat healthily the next 2 years). .
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If you’re offended by the idea that you have a slow, progressive disease, you’re in denial. If you think you can’t do anything about it, you’re even more in denial #agingisadisease.
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Age reversal is real. Trick is landing on A1, not A0
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Living in low 11% oxygen (rather than air at 21%) extends a mouse’s lifespan by 50% and delays the onset of neurological debility in an accelerated aging model. Hormesis?
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Okay, this is a big deal: Vaccinations against aging work. Sure, it’s a proof-of-principle study in a rapidly aging mouse, but there’s little doubt this will be possible in us one day. Link👇1/3
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We become scientists because we're curious, because we're problem-solvers, and because we're addicted to awe. But, like many things people start doing for love, money eventually comes into play. Here's one path for aligning love with reality.
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